Probe for electrofusion, electroporation, or like procedure
The present invention provides a structure and method for treating samples in a well tray. Briefly, the invention contemplates the provision of a probe that is specially configured to engage the well,... Read More
Inventors: Hilliard, Jeffrey L.; Moloney, Maurice M.;, Assignee: Hilliard; Jeffrey L. (Davis, CA) |
Device and method for the electrophoretic separation of macromolecules
The invention relates to an electrophoresis device and an electrophoresis method for the separation of macromolecules and the use of this device. Electrophoresis devices are known for separating macro... Read More
Inventors: Ziegler, Andreas; Geiger, Karl-Heinz;, Assignee: |
Superfusion apparatus
It is an object of the present invention to provide a superfusion apparatus for use in receptor binding procedures providing a higher degree of control features amenable to both chemical and electrica... Read More
Inventors: Bertoncini, Joseph; Kroener, Calvin; Cobb, Wayne; Evans, Robert;, Assignee: Biomedical Research And Development Laboratories, Inc. (Gaithersburg, MD) |
Method and apparatus for administration of anticoagulant to red cell suspension output of a blood separator
OF THE PREFERRED EMBODIMENTS Referring now to the drawings, particularly to FIG. 1, there is illustrated a separation set, generally designated 10, such as described in aforementioned U.S. Pat. No. 4... Read More
Inventors: Schoendorfer, Donald W.;, Assignee: Baxter International Inc. (Deerfield, IL) |
Electroporation device
I claim: 1. An electroporation apparatus for electroporating living cells with molecules comprising: (a) first and second electrodes, respectively having, first and second mutually opposed electrode s... Read More
Inventors: Firth, Kevin L.;, Assignee: |
Implantable electroporation method and apparatus for drug and gene delivery
Accordingly, it is the primary object of the present invention to provide an improved method of electroporation mediated, in vivo, intracellular drug and gene delivery for a living patient. It is anot... Read More
Inventors: Hofmann, Gunter A.;, Assignee: Genetronics, Inc. (San Diego, CA) |
Flow electroporation chamber with electrodes having a crystalline metal nitride coating
The present invention provides improved electrodes for use in generating an electrical field in a saline solution. In particular, the invention relates to continuous crystalline metal nitride coated e... Read More
Inventors: Meserol, Peter;, Assignee: EntreMed, Inc. (Rockville, MD) |
Solely pollen-specific promoter
What is claimed is: 1. An isolated solely pollen-specific promoter derived from Arabidopsis comprising a complete nucleotide sequence of SEQ ID NO: 1 derived from the Arabidopsis AtsPLA.sub.2-.delta. ... Read More
Inventors: Shin, Jeong Sheop; Ryu, Beung Tae; Bahn, Sung Chul; Kim, Hae Jin;, Assignee: Korea University Industry& Academy Cooperation Foundation (Seoul, KR) |
Gene transfer using transformed, neodetermined, embryonic cells
This invention relates to the preparation of carrier cells capable of delivering genetic material to a particular tissue of the body by means of embryonic cells competent to develop into that tissue, ... Read More
Inventors: Wagner, Thomas E.; Reed, Michael A.; Corn, Barbara J.;, Assignee: Ohio University Edison Animal Biotechnology Center (Athens, OH) |
Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
The present invention provides methods and compositions for inhibiting loss of bone mass, and/or for stimulating bone formation in mammals, particularly humans. In one aspect, the invention features a... Read More
Inventors: Kuberasampath, Thangavel; Cohen, Charles M.; Oppermann, Hermann; Ozkaynak, Engin; Rueger, David C.; Pang, Roy H. L.;, Assignee: Creative BioMolecules, Inc. (Hopkinton, MA) |
Imidazole-containing cationic amphiphiles for intracellular delivery of therapeutic molecules
The present invention provides for cationic amphiphiles that are particularly effective to facilitate transport of biologically active molecules into cells. Representative of such amphiphiles are thos... Read More
Inventors: Siegel, Craig S.; Lee, Edward R.; Harris, David J.;, Assignee: Genzyme Corporation (Boston, MA) |
Cationic amphiphiles containing multiplesteroid lipophilic groups
The present invention provides for cationic amphiphiles that are particularly effective to facilitate transport of biologically active molecules into cells. Representative amphiphiles are provided acc... Read More
Inventors: Siegel, Craig S.; Lee, Edward R.; Harris, David J.;, Assignee: Genzyme Corporation (Framingham, MA) |
N-terminally chemically modified protein compositions and methods
What is claimed is: 1. A preparation comprising a predominant amount of a monopolymer/protein conjugate prepared from a hematopoietic protein having one or more available epsilon amino reactive groups... Read More
Inventors: Gabriel, Nancy E.; Farrar, Christine E.;, Assignee: Amgen, Inc. (Thousand Oaks, CA) |
Membrane virus host range mutations and their uses as vaccine substrates
What is claimed is: 1. A genetically engineered Arbovirus comprising, a transmembrane glycoprotein with a deletion of one or more amino acids in a transmembrane domain wherein, said virus is capable o... Read More
Inventors: Hernandez, Racquel; Brown, Dennis T.;, Assignee: Research Development Foundation (Carson City, NV) |
Aminoethylation process for production of substituted ethylene diamines
What is claimed is: 1. A process for preparing a 1,2-ethanediamine in a ring opening reaction of an oxazolidinone, the process comprising contacting an oxazolidinone with an aliphatic secondary amine ... Read More
Inventors: Rooney, Peter C.; Nutt, Michael O.;, Assignee: The Dow Chemical Company (Midland, MI) |
Transdermal thermal polymerization
The present invention, in one aspect, is a method for polymerizing or crosslinking by transdermal thermal energy a perpolymer which has been placed in the body of an animal, and uses thereof. The mate... Read More
Inventors: Ameer, Guillermo A.; Crumpler, Eric T.; Langer, Robert S.;, Assignee: Massachusetts Institute of Technology (Cambridge, MA) |
Method for identifying an oligonucleotide aptamer specific for a target
We claim: 1. A method for identifying an aptamer which specifically binds to thrombin, wherein the aptamer comprises the sequence 5' GGNTGG 3' wherein N is A, T Or G which method comprises: (a) incuba... Read More
Inventors: Toole, John J.; Latham, John; Bock, Louis C.; Griffin, Linda C.;, Assignee: Gilead Sciences, Inc. (Foster City, CA) |
Plant transcription regulators from circovirus
OF THE INVENTION The present invention is further described by reference to the following non-limiting figures and/or examples. Reference herein to a promoter region from SCSV is abbreviated to "S" f... Read More
Inventors: Boevink, Petra Christina; Surin, Brian Peter; Keese, Paul Konrad; Chu, Paul Wing Gay; Waterhouse, Peter Michael; Khan, Rafiqul Islam; Larkin, Philip John; Taylor, William Clark; Marshall, Jerry Stuart;, Assignee: Commonwealth Scientific and Industrial Research Organization (Campbell, AU) |
Methods for modulation of the effects of aging on the primate brain
The invention provides a clinically useful protocol for delivery of recombinant nervous system growth factors into the aging mammalian brain. The invention is particularly useful in tempering and reve... Read More
Inventors: Tuszynski, Mark H.; Blesch, Armin;, Assignee: The Regents of the University of California (Oakland, CA) |
Genetic engineering of cells to enhance healing and tissue regeneration
OF THE INVENTION It has been discovered that cells can be genetically engineered to produce bioactive molecules which act on the cells that are expressing the molecules, or cells adjacent to or in ph... Read More
Inventors: Breitbart, Arnold S.; Grande, Daniel S.; Mason, James M.;, Assignee: North Shore-Long Island Jewish Research Institute (Manhasset, NY) |
Vascular endothelial growth factor-D (VEGF-D) polypeptides
OF THE INVENTION The invention will now be described in detail by reference to the figures, and to the following non-limiting examples. EXAMPLE 1 It has been speculated that no further members of the... Read More
Inventors: Achen, Marc G.; Wilks, Andrew F.; Stacker, Steven A.; Alitalo, Kari;, Assignee: Ludwig Institute for Cancer Research (New York, NY); Helsinki University Licensing Ltd. (Helsinki, FI) |
Methods for treating viral infection using IL-28 and IL-29
We claim: 1. A method of treating a viral infection comprising administering to an immunocompromised mammal with a hepatitis infection a therapeutically effective amount of a polypeptide comprising th... Read More
Inventors: Klucher, Kevin M.; Sivakumar, Pallavur V.; Kindsvogel, Wayne R.; Henderson, Katherine E.;, Assignee: ZymoGenetics, Inc. (Seattle, WA) |
Method of manufacturing an electrohydraulic probe
OF THE INVENTION Referring to FIG. 1 there is shown a diagrammatical view of the bladder 2, ureter 4 and kidney 6 areas of a patient having a lithotriptoscope 8 moving therein. Although the following... Read More
Inventors: Filip, Mihail; D'Amelio, Frank D.;, Assignee: Circon Corporation (Santa Barbara, CA) |
Releasable linkage and compositions containing same
Accordingly, it is an object of the invention to provide a compound where a ligand is covalently yet reversibly linked to a hydrophilic polymer. Upon cleavage of the linkage, the ligand in its native ... Read More
Inventors: Zalipsky, Samuel;, Assignee: Alza Corporation (Mountain View, CA) |
Solid phase dispersion of quinolone or naphthyridonecarboxylic acids
What is claimed is: 1. A solid phase dispersion comprising a micronized quinolinecarboxylic acid or micronized naphthyridonecarboxylic acid in an insoluble matrix, wherein the insoluble matrix is shel... Read More
Inventors: Cabrera, Francisco;, Assignee: Bayer HealthCare LLC (Tarrytown, NY) |
Peptide, process for its preparation and pharmaceutical composition containing same
We claim: 1. pGlu-Pro-Pro-Gly-Gly-Ser-Lys-Val-Ile-Leu-Phe. 2. A pharmaceutical composition for cell-growth stimulating action comprising an effective amount of the compound of claim 1 as active substa... Read More
Inventors: Schaller nee Kornmayer, Hildegard C.; Bodenmuller, Heinz;, Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.v. (Gottingen, DE) |
Stable pharmaceutical composition and method for its production
It is an object of the present invention to provide a stable pharmaceutical composition wherein the absorbability of a lipophilic drug which is insoluble or practically insoluble in water or another d... Read More
Inventors: Yano, Yoshiaki; Masuda, Shigeki; Hidaka, Takayoshi;, Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha (Osaka, JP) |
Pharmaceutical composition for treatment of adult respiratory distress syndrome containing human ANP
The present invention has been accomplished under these circumstances and has as an object providing a pharmaceutical composition effective against ARDS, more specifically, a pharmaceutical compositio... Read More
Inventors: Ueda, Masakazu;, Assignee: Suntory Limited (JP) |
Peptide, a method for its preparation and a pharmaceutical composition containing the peptide
OF THE PREFERRED EMBODIMENT The following standard abbreviations for the amino acid residues are used throughout the specification: Ala--alanine; Glu--glutamic acid; Phe--phenylalanine; Gly--glycine;... Read More
Inventors: Deigin, Vladislav I.; Korotkov, Andrei Marxovich;, Assignee: |
Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX
The invention provides an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human glycoprotein Ib/IX comple... Read More
Inventors: Miller, Jonathan L.; Lyle, Vicki A.;, Assignee: The Research Foundation of State University of New York (Albany, NY) |
Gene Therapy 
