Adjuvant and vaccine compositions containing monophosphoryl lipid A
What is claimed: 1. A lyophilized composition comprising 0.2% up to 5% by weight 3-O-desacyl-4'-monophosphoryl lipid A, at least 70% by weight of sugar and 0% to about 30% by weight of an optionally a... Read More
Inventors: LaPosta, Vincent James; Eldridge, John Hayward;, Assignee: American Cyanamid Company (Madison, NJ) |
Methods for preparation of vaccines against cancer
The present invention relates to methods for producing increased amounts of immunogenic material which can be used for prevention and treatment of cancer. The immunogenic compositions prepared by the ... Read More
Inventors: Srivastava, Pramod K.;, Assignee: Fordham University (Bronx, NY) |
Human genes and gene expression products V
OF THE INVENTION The invention relates to polynucleotides comprising the disclosed nucleotide sequences, to full length cDNA, mRNA genomic sequences, and genes corresponding to these sequences and de... Read More
Inventors: Williams, Lewis T.; Escobedo, Jaime; Innis, Michael A.; Garcia, Pablo Dominguez; Sudduth-Klinger, Julie; Reinhard, Christoph; Giese, Klaus; Randazzo, Filippo; Kennedy, Giulia C.; Pot, David; Kassam, Altaf; Lamson, George; Drmanac, Radoje; Crkvenjakov, Rad, Assignee: Nuvelo, Inc. (Sunnyvale, CA) |
Haptotactic peprides
The invention claimed is: 1. An isolated haptotactic peptide of 20 amino acids consisting of the amino acid sequence as set forth in SEQ ID NO:1, characterized in that the haptotactic peptide induces ... Read More
Inventors: Marx, Gerard; Gorodetsky, Raphael;, Assignee: Hadasit Medical Research Services & Development Company Ltd. (Jerusalem, IL) |
Hepatitis C virus inhibitors
OF THE INVENTION Stereochemical definitions and conventions used herein generally follow McGraw-Hill Dictionary of Chemical Terms, S. P. Parker, Ed., McGraw-Hill Book Company, New York (1984) and Ste... Read More
Inventors: Scola, Paul Michael; Campbell, Jeffrey Allen; Sin, Ny; Sun, Li-Qiang; Wang, Xiangdong Alan;, Assignee: Bristol-Myers Squibb Company (Princeton, NJ) |
Expression of recombinant glyoprotein B from herpes simplex virus
The nucleotide sequence and the amino acid sequence derived therefrom are provided for Herpes Simplex Virus ("HSV") glycoprotein B ("gB") for use in expression of the glycoprotein, synthesis of constr... Read More
Inventors: Burke, Rae L.; Pachl, Carol; Valenzuela, Pablo D. T.;, Assignee: Chiron Corporation (Emeryville, CA) |
Enhancing agent for nerve growth factor production comprising a compound having a coumarin backbone or a compound having a 2-dimethyl chroman backbone
The invention claimed is: 1. A therapeutic agent or prophylactic agent for a disease requiring enhancement of nerve growth factor production, wherein the therapeutic agent or prophylactic agent compri... Read More
Inventors: Ohnogi, Hiromu; Shiraga, Masahiro; Sagawa, Hiroaki; Kato, Ikunoshin;, Assignee: Takara Bio, Inc. (Otsu, JP) |
In vitro packaging of adeno-associated virus DNA
It is an object of the present invention to provide a method for packaging a DNA substrate in an in vitro reaction to produce adeno-associated virus (AAV) particles capable of transduction of mammalia... Read More
Inventors: Zhou, Xiaohuai; Muzyczka, Nicholas; Zolotukhin, Sergei; Ni, Tiehua;, Assignee: Research Foundation of State University of New York (Stony Brook, NY) |
Recombinant viral vector system
The present invention relates to the in vitro synthesis of a novel 165 basepair fragment of DNA which contains AAV ITR sequences and which can be synthesized in vitro and used to engineer expression v... Read More
Inventors: Samulski, Richard Jude; Xiao, Xiao;, Assignee: The University of Pittsburgh (Pittsburgh, PA) |
Modified adeno-associated virus vector capable of expression from a novel promoter
This invention provides an adeno-associated viral vector comprising the inverted terminal repeat sequences of adeno-associated virus and a nucleic acid, wherein the promoter sequence of the inverted t... Read More
Inventors: Carter, Barrie J.; Flotte, Terence; Afione, Sandra; Solow, Rikki;, Assignee: The United States of America as represented by the Department of Health (Washington, DC) |
Culturable mitochondrial cells with no nucleus, showing mitochondrial activity
OF THE INVENTION Hereinafter, the present invention will be described in detail. (1) Method of Producing the Cells of the Present Invention The present invention relates to a method of producing a cu... Read More
Inventors: Nakano, Kazutoshi; Ohta, Shigeo;, Assignee: Eisai Research Institute (Tokyo, JP) |
Antisense oligonucleotides inhibiting human bcl-2 gene expression
The invention provides oligodeoxynucleotides and methods for inhibiting growth of lymphoma or leukemia cells, that are types of lymphocytes. An antisense oligodeoxynucleotide complementary to at least... Read More
Inventors: Reed, John;, Assignee: The Trustees of the University of Pennsylvania (Philadelphia, PA) |
Process for the synthesis of oligomeric compounds
What is claimed is: 1. A method for the preparation of an oligomeric compound having a moiety of Formula I: ##STR38## wherein: X.sub.4 is Z or H; Z is CN, halogen, alkaryl, substituted sulfoxyl, subst... Read More
Inventors: Capaldi, Daniel C.; Ravikumar, Vasulinga T.;, Assignee: Isis Pharmeuticals, Inc. (Carlsbad, CA) |
Process for oligonucleotide synthesis
OF THE PREFERRED EMBODIMENTS The present invention is directed to methods for linking a phosphoramidite nucleoside to a solid support-bound nucleoside. These methods comprise attaching a first nucleo... Read More
Inventors: Scozzari, Anthony;, Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA) |
Derivatized oligonucleotides having improved uptake and other properties
OF THE INVENTION Antisense therapeutics can be practiced in a variety of organisms ranging from unicellular prokaryotic and eukaryotic organisms to multicellular eukaryotic organisms. Any organism th... Read More
Inventors: Manoharan, Muthiah; Cook, Phillip Dan; Bennett, Clarence Frank;, Assignee: ISIS Pharmaceuticals, Inc. (Carlsbad, CA) |
Process for the synthesis of oligomeric compounds
What is claimed is: 1. A compound having the formula: ##STR38## wherein: X.sub.4 is Z or H; Z is CN, a halogen radical, , alkaryl, substituted sulfoxyl, substituted sulfonyl, or substituted thio, wher... Read More
Inventors: Capaldi, Daniel C.; Ravikumar, Vasulinga T.;, Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA) |
Processes for the synthesis of oligomeric compounds
OF PREFERRED EMBODIMENTS The present invention provides methods for the preparation of oligomeric compounds having at least one phosphodiester or phosphorothioate internucleoside linkage. Oligomeric ... Read More
Inventors: Manoharan, Muthiah;, Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA) |
Methods of synthesis and use of radiolabelled platinum chemotherapeutic agents
OF THE INVENTION Usually, in the method of synthesis of the radiolabelled platinum chemotherapeutic agent the step of converting the metal halide into a radiolabelled platinum halide is carried out i... Read More
Inventors: Smith, Suzanne V.;, Assignee: Australian Nuclear Science & Technology Organisation (New South Wales, AU) |
Pharmaceutical composition for diabetic neuropathy
What is claimed is: 1. A method for the prophylaxis of diabetic peripheral neuropathy, which comprises administering an effective amount of cytidine 5'-diphosphocholine or a pharmaceutically acceptabl... Read More
Inventors: Endo, Kazuki; Abiru, Toichi; Kamei, Junzo;, Assignee: Yamasa Corporation (Chiba, JP) |
Rapid single-cycle assay for human immunodeficiency virus type-1 drug resistance
This invention aids in fulfilling this need in the art by providing an in vitro, single cycle, recombinant virus assay (RVA) for determining inhibition of HIV replication by a protease inhibitor. The ... Read More
Inventors: Paulous, Sylvie; Charneau, Pierre; Zennou, Veronique; Clavel, Francois;, Assignee: Institut Pasteur (Paris, FR) |
Compositions and methods for sensitive detection of HIV infection and monitoring of drug resistance
OF THE INVENTION The present invention relates to new and useful methods including methods for detecting HIV, methods for detecting HIV drug resistance, methods for designing patient customized anti-... Read More
Inventors: Dong, Jian-yung;, Assignee: MUSC Foundation for Research Development (Charleston, SC) |
Continuous process for ethanol production by bacterial fermentation
The accompanying FIGURE will provide a background for the following discussion in which the method and apparatus for carrying out this invention are described in detail. Referring to the FIGURE, nutr... Read More
Inventors: Lawford, Hugh G.;, Assignee: George Weston Limited (Toronto, CA) |
Stable solution of hyaluronate in a balanced salt medium
What is claimed is: 1. A physiological visco-elastic formulation consisting of sodium hyaluronate in an amount in the range of about 0.1% to about 5% by weight in a balanced salt aqueous solution cons... Read More
Inventors: Mello, Robert J.; Tew, William P.; Beaty, Narlin B.;, Assignee: Allergan (Waco, TX) |
Radiolabeled fusion toxins for cancer therapy
The present invention describes the synthesis and purification of a new class of compounds known as radiolabeled fusion toxins (RFT), in which both toxin and radionuclide tags are contained on the sam... Read More
Inventors: Buchsbaum, Donald J.; Blazar, Bruce R.; Vallera, Daniel A.;, Assignee: UAB Research Foundation (Birmingham, AL) |
Genetically modified cells expressing a TGF.beta. inhibitor, the cells being lung cancer cells
OF THE PREFERRED EMBODIMENT Lung cancers account for 30% of all death due to cancer in the United States (Ramanathan and Belani, 1997). The overall cure rate for lung cancer is 13% and the current pr... Read More
Inventors: Fakhrai, Habib;, Assignee: NovaRx (San Diego, CA) |
Auto-ligating oligonucleotide compounds
OF THE INVENTION The invention relates to a method and compositions for in situ formation of an effective antisense compound or probe on a target polynucleotide. Compositions of the invention compris... Read More
Inventors: Gryaznov, Sergei M.;, Assignee: Lynx Therapeutics, Inc. (Hayward, CA) |
Nucleic acids encoding transcription factor APRF (acute phase response factor)
What is claimed: 1. An isolated DNA molecule which encodes a human APRF polypeptide having the amino acid sequence of SEQ ID No:1. 2. An isolated DNA molecule comprising the nucleotide sequence of SEQ... Read More
Inventors: Kishimoto, Tadamitsu; Akira, Shizuo;, Assignee: Kishimoto; Tadamitsu (Osaka, JP) |
Antisense modulation of stat3 expression
OF THE INVENTION STAT3 plays an important role in cytokine signal transduction. Overexpression and/or constitutive activation of STAT3 is associated with a number of inflammatory diseases and cancers... Read More
Inventors: Karras, James G.;, Assignee: Isis Pharmaceuticals Inc. (Carlsbad, CA) |
Cold-active beta-galactosidase, the process for its preparation and the use thereof
The object of the present invention is to hydrolyse lactose by using a .beta.-galactosidase, which could overcome the above-mentioned drawbacks which are usually associated to this process, while adva... Read More
Inventors: Hoyoux, Anne; Fran.cedilla.ois, Jean-Marie; Dubois, Phillip; Baise, Etienne; Jennes, Isabell; Genicot, Sabine; Gerday, Charles;, Assignee: Universite de Liege (Liege, BE) |
Method of delivering powder transdermally with needless injector
What we claim is: 1. A method of therapeutic treatment, comprising transdermally delivering particles of a powdered therapeutic agent across skin tissue of a mammalian subject, said particles being de... Read More
Inventors: Bellhouse, Brian J.; Sarphie, David F.; Greenford, John C.;, Assignee: Oxford Biosciences Limited (Oxford, GB2) |
Gene Therapy 
