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Results: 151-180 of 4797
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Telomere repeat binding factors and diagnostic and therapeutic use thereof
The present invention provides vertebrate telomeric binding factors (TRFs) that bind to the TTAGGG repeat sequences of telomeres. Such TRFs comprise two key domains: a dimerization domain, and a Myb d... Read More
Inventors: DeLange, Titia; Broccoli, Dominique; Smogorzenska, Agata;, Assignee: The Rockfeller University (New York, NY) |
Protease-activated receptor PAR4 (ZCHEMR2)
What is claimed is: 1. An isolated polynucleotide molecule that encodes a polypeptide comprising amino acid residues 48 to 78 of SEQ ID NO:2. 2. The isolated polynucleotide molecule of claim 1, where... Read More
Inventors: Xu, Wen-feng; Presnell, Scott R.; Yee, David P.; Foster, Donald C.;, Assignee: ZymoGenetics, Inc. (Seattle, WA) University of Washington (Seattle, WA) |
Systemic drug delivery compositions comprising a polycationi substance
I claim: 1. A method of systemically delivering a pharmaceutically effective amount of a pharmacologically active compound to a mammal comprising: administering to a mucosal surface a composition incl... Read More
Inventors: Illum, Lisbeth;, Assignee: Danbiosyst UK Limited (Nottingham, GB) |
Nucleic acid-containing composition, its preparation and use
We claim: 1. A composition comprising a deoxyribonucleic acid and a cationic oligopeptide that forms secondary structures, wherein the oligopeptide corresponds to the formula (A.sub.0 A.sub.y A.sub.y ... Read More
Inventors: Bazile, Didier; Emile, Carole; Helene, Claude; Spenlehauer, Gilles;, Assignee: Rhone-Poulenc Rorer SA (Anthony Cedex, FR) |
Peptide-enhanced cationic lipid transfections
OF THE INVENTION The present invention provides improved methods for transfecting eukaryotic cells with nucleic acids by employing peptides or modified peptides in combination with transfection agent... Read More
Inventors: Hawley-Nelson, Pamela; Lan, Jianqing; Shih, PoJen; Jessee, Joel A.; Schifferli, Kevin P.; Gebeyehu, Gulilat;, Assignee: Life Technologies, Inc. (Rockville, MD) |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
It is therefore an object of the present invention to provide a controlled release formulation of a substrate comprising an active agent, e.g. a therapeutically active agent, a disinfecting agent, a c... Read More
Inventors: Oshlack, Benjamin; Chasin, Mark; Pedi, Jr., Frank;, Assignee: Purdue Pharma LP (Stamford, CT) |
Xylofuranosly-containing nucleoside phosphoramidites and polynucleotides
What is claimed is: 1. A compound having the formula I: ##STR5## wherein, R.sub.1 is OH, O--R.sub.3, C--R.sub.3, halo, NHR.sub.4, ONHR.sub.5 or ON.dbd.R.sub.6, wherein R.sub.3 is independently a moiet... Read More
Inventors: Matulic-Adamic, Jasenka; Beigelman, Leonid;, Assignee: Ribozyme Pharmaceuticals, Inc. (Boulder, CO) |
Substituted indazole-O-glucosides
OF THE INVENTION All diabetics, regardless of their genetic and environmental backgrounds, have in common an apparent lack of insulin or inadequate insulin function. Because transfer of glucose from ... Read More
Inventors: Patel, Mona; Rybczynski, Philip J.; Urbanski, Maud; Zhang, Xiaoyan;, Assignee: Janssen Pharmaceutica, N.V. (Beerse, BE) |
Production in Escherichia coli of extracellular Serratia spp. hydrolases
We claim: 1. A method of producing an extracellular hydrolytic Serratia spp. enzyme selected from the group consisting of exocellular nuclease, exocellular phospholipase and exocellular lipase, compri... Read More
Inventors: Molin, Soren; Givskov, Michael; Riise, Erik;, Assignee: Benzon Pharma, A/S (Hvidovre, DK) |
Modular assembly of antibody genes, antibodies prepared thereby and use
What is claimed is: 1. A polynucleotide molecule encoding an immunoglobulin fragment, said immunoglobulin fragment comprising a first DNA sequence encoding a first pectate lyase secretion signal seque... Read More
Inventors: Robinson, Randy R.; Liu, Alvin Y.; Horwitz, Arnold H.; Better, Marc; Wall, Randolph; Lei, Shau-Ping; Wilcox, Gary L.;, Assignee: Xoma Corporation (Berkeley, CA) |
Cytoplasmic bacteriophage display system
The present invention relates, in one aspect, to a display vector comprising DNA encoding a portion of a structural protein from a cytoplasmic bacteriophage, joined covalently to a protein or peptide ... Read More
Inventors: Studier, F. William; Rosenberg, Alan H.;, Assignee: Associated Universities Inc. (Washington, DC) |
Diagnosis of alzheimer disease stage by mononuclear cell cytokine secretions
AND ADVANTAGES According to the present invention, a method of diagnosing and determining the disease stage or severity of a degenerative disease of the central nervous system (CNS) associated with th... Read More
Inventors: Sredni, Benjamin; Huberman, Moshe; Shalit, Francis;, Assignee: Bar-Ilan University (Ramat Gan, IL); Mor Research Applications Ltd. (Givet Shmuel, IL) |
Polyvalent display libraries
I. General The present invention is directed to inter alia two related but self-sufficient improvements in conventional display methods. The first improvement provides methods of enriching convention... Read More
Inventors: Buechler, Joe; Valkirs, Gunars; Gray, Jeff;, Assignee: Biosite Diagnostics, Inc. (San Diego, CA) |
Synthetic human neutralizing monoclonal antibodies to human immunodeficiency virus
OF THE INVENTION A. Definitions Amino Acid Residue: An amino acid formed upon chemical digestion (hydrolysis) of a polypeptide at its peptide linkages. The amino acid residues described herein are pr... Read More
Inventors: Barbas, Carlos F.; Burton, Dennis R.; Lerner, Richard A.;, Assignee: The Scripps Research Institute (La Jolla, CA) |
Pharmaceutical and diagnostic business systems and methods
Improved business methods, devices, and systems for utilizing genetic information are provided. According to one embodiment of the invention a business method is provided that includes the steps of sc... Read More
Inventors: Margus, Bradley A.; Cox, David R.; Fodor, Stephen P. A.;, Assignee: Perlegen Sciences, Inc. (Mountain View, CA) |
Addition compound of a nucleotide and an amino acid and the use thereof in protection against actinic radiation
I claim: 1. A topical composition for protection against actinic radiation, comprising a dermatologically acceptable inert carrier suitable for application to human skin, and having dispersed therein ... Read More
Inventors: Jacobi, Otto K.;, Assignee: Kolmar Laboratories, Inc. (Port Jervis, NY) |
Method of differential display of exposed mRNA by RT/PCR
We claim: 1. A method of comparing the presence or level of individual mRNA molecules in two or more nucleic acid samples, comprising the steps of: providing a first nucleic acid sample including mRNA... Read More
Inventors: Liang, Peng; Pardee, Arthur B.; Bianchi, Cesario F.;, Assignee: Dana-Farber Cancer Institute, Inc. (Boston, MA); The President and Fellows of Harvard College (Cambridge, MA) |
Methods of screening for compounds that derepress or increase telomerase activity
We claim: 1. Method for screening for a telomerase derepression agent, the method comprising the steps of: contacting a cell lacking telomerase activity with a potential telomerase derepression agent,... Read More
Inventors: West, Michael D.; Harley, Calvin B.; Weinrich, Scott L.; Strahl, Catherine M.; McEachern, Michael J.; Shay, Jerry; Wright, Woodring E.; Blackburn, Elizabeth H.; Kim, Nam Woo; Vaziri, Homayoun;, Assignee: Board of Regents, The University of Texas System (Dallas, TX); The Regents of the University of California (Oakland, CA); Geron Corporation (Menlo Park, CA) |
Oral vaccines
What is claimed is: 1. A protein conjugate comprising an immunogen covalently linked to a carrier molecule, wherein said carrier molecule is capable of specifically interacting with the mucosal epithe... Read More
Inventors: Russell-Jones, Gregory John; Howe, Peter; de Aizpurua, Henry James; Rand, Keith Norman;, Assignee: Biotechnology Australia PTY, LTD (New South Wales, AU) |
Method for identifying validated target and assay combinations for drug development
The invention relates to methods that couple the validation of a target (see Definitions) for drug discovery with the development of an assay to identify compounds that cause a phenotypic effect on th... Read More
Inventors: Tally, Francis P.; Tao, Jianshi; Wendler, Philip A.; Connelly, Gene; Gallant, Paul L.; Shen, Xiaoyu; Zhang, Jiansu;, Assignee: Cubist Pharmaceuticals, Inc. (Lexington, MA) |
Synthetic DNA sequences having enhanced expression in monocotyledonous plants and method for preparation thereof
OF THE PREFERRED EMBODIMENTS The following definitions are provided for clarity of the terms used in the description of this invention. "Rare monocotyledonous codons" refers to codons which have an a... Read More
Inventors: Brown, Sherri Marie; Dean, Duff Allen; Fromm, Michael Ernest; Sanders, Patricia Rigden;, Assignee: Monsanto Company (St. Louis, MO) |
Synthetic oligomers having chirally pure phoshonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages
OF THE INVENTION The phosphonate internucleosidyl linkages used in oligomers of the present invention contain an lower alkyl group replacing one of the two non-bonding (or non-bridging) oxygens on th... Read More
Inventors: Arnold, Jr., Lyle J.; Hogrefe, Richard I.; Reynolds, Mark A.; Riley, Timothy A.; Schwartz, David A.;, Assignee: Genta, Incorporated (San Diego, CA) |
Sequence specific DNA binding by p53
It is an object of the invention to provide a method for detecting the presence of wild-type p53 protein in a cell. It is another object of the invention to provide a method for providing the physiolo... Read More
Inventors: Vogelstein, Bert; Kinzler, Kenneth W.; Sherman, Michael I.;, Assignee: The John Hopkins University (Baltimore, MD); PharmaGenics, Inc. (Allendale, NJ) |
C-pyrazole A.sub.2A receptor agonists
We claim: 1. A composition of matter having the formula: ##STR00032## 2. A method for stimulating coronary vasodilatation in a mammal by administering to the mammal a therapeutically effective amount... Read More
Inventors: Zablocki, Jeff A.; Elzein, Elfatih O.; Palle, Venkata P.;, Assignee: CV Therapeutics, Inc. (Palo Alto, CA) |
Cell lines and constructs useful in production of E1-deleted adenoviruses in absence of replication competent adenovirus
Advantageously, the present invention provides E1 expressing cell lines that are stable, can be adapted to suspension culture in serum free medium, and yields high quantity of vector. Significantly, t... Read More
Inventors: Gao, Guangping; Wilson, James M.;, Assignee: The Trustees of the University of Pennsylvania (Philadelphia, PA) |
Method for investigating the condition of a bacterial suspension through frequency profile of electrical admittance
We claim: 1. A method of investigating the condition of a suspension of bacteria in a fluid medium, comprising the steps of: (a) positioning a sample of said suspension in a test cell having spaced el... Read More
Inventors: Blake-Coleman, Barrie C.; Clarke, David J.;, Assignee: Public Health Laboratory Service Board (GB2) |
Apparatus and methods for electroporation and electrofusion
To achieve the objects of this invention, a method of electroporation of a first type of cells is provided by placing the first type of cells in a solution held by a container in which an insulating f... Read More
Inventors: Schmukler, Robert E.;, Assignee: |
Controlled electroporation and mass transfer across cell membranes
The present invention arises in part from the discovery that the onset and extent of electroporation in a biological cell can be correlated to changes in the electrical impedance (which term is used h... Read More
Inventors: Rubinsky, Boris; Huang, Yong;, Assignee: The Regents of the University of California (Oakland, CA) |
Antisense oligonucleotide alkylphosphonothioates and arylphospohonothioates
In a first aspect, the invention provides a method for synthesizing oligonucleotides having alkylphosphonothioate or arylphosphonothioate internucleotide linkages. The method of the invention is readi... Read More
Inventors: Padmapriya, A.; Agrawal, Sudhir;, Assignee: Hybridon, Inc. (Milford, MA) |
Polymer controlled induced viscosity fiber system and uses thereof
OF THE INVENTION As used in this application: a. "glycemic index" (GI) is calculated by dividing the blood glucose incremental area under the curve (AUC) of the test food by the blood glucose AUC of ... Read More
Inventors: Wolf, Bryan W.; Blidner, Bruce B.; Garleb, Keith A.; Lai, Chron-Si; Schenz, Timothy W.;, Assignee: Abbott Laboratories (Abbott Park, IL) |
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Gene Therapy 
