|
| Latest patents |
Results: 181-210 of 4797
|
Methods and compositions for expression of competent eukaryotic gene products
DNA constructions are provided comprising control elements derived from heat-shock genes associated with genes of interest, which permit the expression of the gene of interest in both procaryotic and ... Read More
Inventors: Bromley, Peter; Voellmy, Richard;, Assignee: Rockwell Property Limited (Isle of Man, GB) |
Thymidine kinase mutants
Briefly stated, the present invention provides compositions and methods which utilize Herpesviridae thymidine kinase mutants. Within one aspect of the present invention, isolated nucleic acid molecule... Read More
Inventors: Loeb, Lawrence A.; Black, Margaret E.;, Assignee: University of Washington (Seattle, WA) |
Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
We claim: 1. An enzymatic nucleic acid molecule comprising a 5'-cap structure, a 3'-cap structure, or both a 5'- and a 3'-cap structure, wherein said 5'-cap structure is selected from the group consis... Read More
Inventors: Matulic-Adamic, Jasenka; Beigelman, Leonid; Karpeisky, Alexander; Jarvis, Thale; Usman, Nassim; DiRenzo, Anthony; Wincott, Francine;, Assignee: Ribozyme Pharmaceuticals, Inc. (Boulder, CO) |
Peptide acceptor ligation methods
What is claimed is: 1. A method of affixing a peptide acceptor to an RNA molecule, said method comprising: (a) providing an RNA molecule having a 3' sequence which forms a hairpin structure; (b) provi... Read More
Inventors: Kurz, Markus; Lohse, Peter; Wagner, Richard;, Assignee: Compound Therapeutics, Inc. (Waltham, MA) |
Solid phase diagnosis of medical conditions
I claim: 1. A method for detecting a target polynucleotide that is characteristic of a pathological condition, comprising the steps of: (a) producing a first amplified DNA by a first polymerass chain ... Read More
Inventors: Uhlen, Mathias;, Assignee: CEMU Bitecknik AB (Uppsala, SE) |
Use of microparticles combined with submicron oil-in-water emulsions
OF THE INVENTION The practice of the present invention will employ, unless otherwise indicated, conventional methods of chemistry, biochemistry, molecular biology, immunology and pharmacology, within... Read More
Inventors: O'Hagan, Derek; Van Nest, Gary; Ott, Gary S.; Singh, Manmohan;, Assignee: Chiron Corporation (Emeryville, CA) |
Methods of treating hypertension and compositions for use therein
The present invention provides methods of treating hypertension, particularly essential hypertension. The methods generally involve providing a stimulator of angiogenesis and/or of blood vessel porosi... Read More
Inventors: Schreiner, George F.; Johnson, Richard J.;, Assignee: Scios Inc. (Sunnyvale, CA) |
Use of microparticles combined with submicron oil-in-water emulsions
OF THE INVENTION The practice of the present invention will employ, unless otherwise indicated, conventional methods of chemistry, biochemistry, molecular biology, immunology and pharmacology, within... Read More
Inventors: O'Hagan, Derek; Van Nest, Gary; Ott, Gary S.; Singh, Manmohan;, Assignee: Chiron Corporation (Emeryville, CA) |
6,11-bicyclic erythromycin derivatives
OF THE INVENTION A first embodiment of the present invention is a compound of formula I as defined herein, or its pharmaceutically acceptable salt, ester, or prodrug. Representative subgenera of the ... Read More
Inventors: Or, Yat Sun; Wang, Guoqiang; Phan, Ly Tam; Niu, Deqiang; Qiu, Yao-Ling; Vo, Nha Huu; Farmer, Jay Judson; Hou, Ying;, Assignee: Enanta Pharmaceuticals, Inc. (Watertown, MA) |
Method of producing infectious reovirus
OF THE INVENTION The present invention is directed to a method of producing mammalian reovirus by using human embryo kidney 293 (HEK 293) cells. We found that HEK 293 cell are a more efficient host c... Read More
Inventors: Thompson, Bradley G.; Coffey, Matthew C.;, Assignee: Oncolytics Biotech Inc. (Calgary, unknown) |
CDNA sequences of human bone matrix proteins
It is, therefore, an object of the present invention to provide specific cDNA and deduced protein sequences which are diagnostic of such human diseases as osteoporosis, osteo/rheumatold arthritis, Pag... Read More
Inventors: Termine, John D.; Young, Marian F.; Fisher, Larry W.; Robey, Pamela G.;, Assignee: The United States of Americas as represented by the Secretary of Health (Washington, DC) |
Antisense inhibition of PEPCK-mitochondrial expression
OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid molecules encoding PEPCK-mitochondrial... Read More
Inventors: McKay, Robert; Butler, Madeline M.; Cowsert, Lex M.;, Assignee: Isis Pharmaceuticals Inc. (Carlsbad, CA) |
Methods of modulating tumor necrosis factor .alpha.-induced expression of cell adhesion molecules
OF THE INVENTION The present invention employs specific inhibitors of Ha-ras, c-raf and JNK2, members of the TNF-.alpha. signaling pathway, to modulate cell adhesion molecule expression. These inhibi... Read More
Inventors: Monia, Brett P.; Xu, Xiaoxing S.;, Assignee: Isis Pharmaceuticals Inc. (Carlsbad, CA) |
Antisense modulation of telomeric repeat binding factor 1 expression
OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid molecules encoding Telomeric Repeat Bi... Read More
Inventors: Monia, Brett P.; Cowsert, Lex M.;, Assignee: Isis Pharmaceuticals Inc. (Carlsbad, CA) |
Antisense modulation of interleukin-5 signal transduction
OF THE INVENTION The present invention comprehends antisense compounds capable of modulating IL-5 signal transduction, preferably by modulating expression of IL-5 or IL-5 receptor.alpha.. These compo... Read More
Inventors: Dean, Nicholas M.; Karras, James G.; McKay, Robert;, Assignee: Isis Pharmaceuticals Inc. (Carlsbad, CA) |
Antisense modulation of P38 mitogen activated protein kinase expression
OF THE INVENTION p38 MAPKs play an important role in signal transduction in response to cytokines, growth factors and other cellular stimuli. Specific responses elicited by p38 include inflammatory a... Read More
Inventors: Monia, Brett P.; Gaarde, William A.; Nero, Pamela S.; McKay, Robert;, Assignee: Isis Pharmaceuticals Inc. (Carlsbad, CA) |
Antisense modulation of CD44 expression
OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid molecules encoding CD44, ultimately mo... Read More
Inventors: Bennett, C. Frank; Cowsert, Lex M.;, Assignee: Isis Pharmaceuticals Inc. (Carlsbad, CA) |
Antisense modulation of Smad7 expression
OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid molecules encoding Smad7, ultimately m... Read More
Inventors: Monia, Brett P.; Cowsert, Lex M.;, Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA) |
Antisense modulation of nucleolin expression
OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid molecules encoding Nucleolin, ultimate... Read More
Inventors: Bennett, C. Frank; Cowsert, Lex M.;, Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA) |
Antisense modulation of hnRNP A1 expression
OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid molecules encoding hnRNP A1, ultimatel... Read More
Inventors: Monia, Brett P.; Cowsert, Lex M.;, Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA) |
Antisense inhibition of E2F transcription factor 3 expression
OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid molecules encoding E2F transcription f... Read More
Inventors: Popoff, Ian; Wyatt, Jacqueline;, Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA) |
Antisense inhibition of rank expression
OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid molecules encoding RANK, ultimately mo... Read More
Inventors: Baker, Brenda F.; Cowsert, Lex M.;, Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA) |
Antisense inhibition of protein kinase C-theta expression
OF THE INVENTION The present invention employs oligomeric antisense compounds, particularly oligonucleotides, for use in modulating the function of nucleic acid molecules encoding Protein kinase C-th... Read More
Inventors: Bennett, C. Frank; Cowsert, Lex M.;, Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA) |
Antisense oligonucleotide modulation of human mdm2 expression
OF THE INVENTION Tumors often result from genetic changes in cellular regulatory genes. Among the most important of these are the tumor suppressor genes, of which p53 is the most widely studied. Appr... Read More
Inventors: Miraglia, Loren J.; Nero, Pamela; Graham, Mark J.; Monia, Brett P.;, Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA) |
Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
The term "alkyl" as used herein means straight and branched carbon chains of one to twenty carbons, preferably one to six carbons and more preferably one to three carbons. The term "alkenyl" as used ... Read More
Inventors: Ganguly, Ashit K.; McCormick, Jinping; Lovey, Raymond G.; Bennett, Frank; Saksena, Anil K.; Girijavallabhan, Viyyoor M.;, Assignee: Schering Corporation (Kenilworth, NJ) |
Antibacterial agents comprising conjugates of glycopeptides and peptidic membrane associating elements
What is claimed is: 1. An antibacterial compound of formula V-L-W-X; wherein: V is a glycopeptide moiety which inhibits peptidoglycan biosynthesis in bacteria; L is a linking group; W is a peptidic me... Read More
Inventors: Cooper, Matthew Allister; Betley, Jason Richard;, Assignee: Cambridge University Technical Services Limited (Cambridge, GB) Adprotech Limited (Essex, GB) |
System and method for enhancing cardiac signal sensing by cardiac pacemakers through genetic treatment
In accordance with the above, a primary purpose of Applicants' claimed invention is to provide methods and delivery systems for enhancing cardiac pacemaker signal sensing. In a particular embodiment, ... Read More
Inventors: Stokes, Kenneth B.; Morissette, Josee;, Assignee: Medtronic, Inc. (Minneapolis, MN) |
Recombinant allergenic proteins from ragweed pollen
The present invention relates to allergenic proteins or peptides from ragweed, DNAs encoding all or a portion of such allergenic proteins or peptides; to compositions containing such an allergen(s) or... Read More
Inventors: Rogers, Bruce; Klapper, David G.; Rafnar, Thorunn; Kuo, Mei-chang;, Assignee: ImmuLogic Pharmaceutical Corporation (Waltham, MA); University of North Carolina at Chapel Hill (Chapel Hill, NC) |
Nucleic acids encoding allergenic proteins from ragweed
The present invention relates to allergenic proteins or peptides from ragweed, DNAs encoding all or a portion of such allergenic proteins or peptides; to compositions containing such an allergen(s) or... Read More
Inventors: Rogers, Bruce; Klapper, David G.; Rafnar, Thorunn; Kuo, Mei-chang;, Assignee: ImmuLogic Pharmaceutical Corporation (Waltham, MA); the University of North Carolina at Chapel Hill (Chapel Hill, NC) |
Lactobacilli harboring aggregation gene as a vaccine delivery vehicle
OF THE INVENTION As used herein and in the claims, the term "animal" means mammals and avians, with humans being the animal of greatest interest. As used herein and in the claims, the term "L. reuter... Read More
Inventors: Casas, Ivan; Jonsson, Hans; Mollstam, Bo; Roos, Stefan;, Assignee: BioGaia Biologies AB (Stockholm, SE) |
|
Gene Therapy 
