Delivery and expression of a hybrid surface protein on the surface of gram positive bacteria
What is claimed is: 1. An isolated and purified DNA molecule encoding a hybrid protein, said hybrid protein comprising a heterologous polypeptide attached to the N-terminal end of the anchor region of... Read More
Inventors: Fischetti, Vincent A.; Pozzi, Gianni; Schneewind, Olaf;, Assignee: The Rockefeller University (New York, NY) |
Lentiviral packaging constructs
OF THE INVENTION The practice of the present invention will employ, unless otherwise indicated, conventional techniques of cell biology, molecular biology, cell culture, virology, and the like which ... Read More
Inventors: Kaleko, Michael; Luo, Tianci; Plavec, Ivan; Douglas, Janet Lynn;, Assignee: Novartis AG (Basel, CH) |
Method for measuring no synthase activity
OF THE INVENTION In the context of the present invention the following definitions apply: Incubation: the introduction and leaving of a biological object, such as an enzyme, NOS, in a medium to which... Read More
Inventors: Hennies, Hagen-Heinrich; Sundermann, Bernd;, Assignee: Gruenenthal GmbH (Aachen, DE) |
Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides
In one aspect, the present invention pertains to the discovery herein that Wnt polypeptides ("Wnts"), such as Wnt-5a, play a role in hematopoiesis. In another aspect, the present invention is based on... Read More
Inventors: Matthews, William; Austin, Timothy W.;, Assignee: Genentech, Inc. (South San Francisco, CA) |
Hydrogel compositions for controlled delivery of virus vectors and methods of use thereof
The invention relates to a composition for delivery of a virus vector to an animal cell. The composition comprises a hydrogel precursor mixture having the virus vector suspended therein. The hydrogel ... Read More
Inventors: Levy, Robert J.; Crombleholme, Timothy; Vyavahare, Narendra;, Assignee: The Children's Hospital of Philadelphia (Philadelphia, PA) |
Particle delivery techniques
OF THE PREFERRED EMBODIMENTS The practice of the present invention will employ, unless otherwise indicated, conventional methods of molecular biology and recombinant DNA techniques within the skill o... Read More
Inventors: Burkoth, Terry Lee; Sarphie, David Francis; Muddle, Andrew Gordon; Porter, Linda Maree;, Assignee: Powderject Research Limited (GB) |
Tissue anchor system
The invention claimed is: 1. An adjustable tissue anchor comprising: a. an anchor body having a first and second open end with an interior chamber running between said open ends, said interior chamber... Read More
Inventors: Walshe, Christopher J.;, Assignee: |
Ribozyme mediated inactivation of the androgen receptor
The present invention describes inactivation of AR gene expression by engineering hammerhead ribozymes to cleave specific sites in AR mRNA. The present in vitro studies of hammerhead ribozymes reveal ... Read More
Inventors: Roy, Arun K; Chen, Shuo;, Assignee: Board of Regents, The University of Texas System (Austin, TX) |
Thyrotropin-releasing hormone analogues and their therapeutic applications
The present invention pertains to novel TRH analogues, compositions, and methods for the controlled administration of novel TRH analogues to mammals. The present invention preferably provides centrall... Read More
Inventors: Prokai, Laszlo;, Assignee: University of Florida ( |
Probiotics in primary prevention of atopic diseases
What is claimed is: 1. A method for prevention of atopic diseases selected from the group consisting of atopic eczema, allergic rhinitis and asthma in an infant at high risk of said atopic diseases, c... Read More
Inventors: Isolauri, Erika; Salminen, Seppo;, Assignee: |
Humanin-like peptide and use thereof
The invention claimed is: 1. A polypeptide comprising an amino acid sequence as shown in SEQ ID NO: 4, or an amide, ester or salt thereof. 2. The polypeptide according to claim 1 consisting of the am... Read More
Inventors: Sugo, Tsukasa; Mori, Masaaki;, Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP) |
Use of N-acetyl-D-glucosamine in the manufacture of pharmaceutical useful for suppressing side-effect of radiotherapy and chemotherapy
The invention claimed is: 1. A method for treating a cancer patient who is undergoing or has undergone a radiation therapy or chemotherapy treatment, the method comprising administering to said patien... Read More
Inventors: Xu, Qiwang; Liu, Junkang; Yuan, Zetao;, Assignee: Third Military Medical University, Chinese People's Liberation Army, P.R. of China (Chongqing, CN); Bio-Wave Institute of Suzhou Hi-Tech New District Corporation, LTD (Jiangsu, CN); Beijing Sino-Hongkong Dafu Science & Technology of Biowave Co., Ltd. (Bei |
Method of treating cardiovascular diseases
OF PREFERRED EMBODIMENTS As examples of the diseases which the method according to the invention is useful to prevent or alleviate, there are mentioned eye diseases such as retinitis pigmentosa or da... Read More
Inventors: Siren, Matti;, Assignee: Perstorp AB (Perstorp, SE) |
Rapid production of autologous tumor vaccines
In accordance with the present invention an autologous vaccine to tumor cells is produced by transducing the tumor cells with a herpes simplex virus amplicon containing the gene for an immunostimulati... Read More
Inventors: Fong, Yuman; Federoff, Howard; Rosenblatt, Joseph D.;, Assignee: Sloan-Kettering Institute for Cancer Research (New York, NY); University of Rochester (Rochester, NY) |
Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
OF THE INVENTION In accordance with the invention novel therapeutic use is provided for certain active agents, particularly adenosine receptor agonists and antagonists. By one embodiment, the G-CSF-i... Read More
Inventors: Fishman, Pina;, Assignee: Can-Fite Biopharma Ltd. (Petach Tikva, IL) |
Engineered protein kinases which can utilize modified nucleotide triphosphate substrates
OF THE INVENTION Inhibition of Engineered Kinases FIG. 9 shows a schematic representation of an experiment to identify kinase substrates below which uses the invention for discovery of the substrates... Read More
Inventors: Shokat, Kevan M.;, Assignee: Princeton University (Princeton, NJ) |
Method for the production of bacterial toxins
The present invention is based upon the discovery that bacterial toxin expression inhibitors accumulate in culture media and thus significantly reduce toxin production. Moreover, the present invention... Read More
Inventors: Blake, Milan S.; Bogdan, Jr., John A.; Nazario-Larrieu, Javier;, Assignee: Baxter International Inc. (Deerfield, IL); Baxter Healthcare S.A. (Zurich, CH) |
Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
OF PREFERRED EMBODIMENTS In its preferred embodiments, this invention involves preparation and administration of novel lactone stable HECPT formulations as described below. EXAMPLES The following exa... Read More
Inventors: Hausheer, Frederick H.; Haridas, Kochat;, Assignee: Bionumerik Pharmaceuticals, Inc. (San Antonio, TX) |
Modified protein kinase A-specific oligonucleotides and methods of their use
The present invention relates to modified oligonucleotides useful for studies of gene expression and for the antisense therapeutic approach. The invention provides modified oligonucleotides that down-... Read More
Inventors: Agrawal, Sudhir;, Assignee: Hybridon, Inc. (Cambridge, MA) |
Peptides and nucleic acid sequences related to the Epstein Barr virus
OF THE INVENTION The term "peptide" as used herein refers to a molecular chain of amino acids with a biological activity, and does not refer to a specific length of the product. Thus inter alia, prot... Read More
Inventors: Middeldorp, Jaap M.; van Grunsven, Wouterus M. J.;, Assignee: Akzo N.V. (Arnhem, NL) |
Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders
The present invention provides a method of optimizing therapeutic efficacy of 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder. The method includes the steps of administ... Read More
Inventors: Seidman, Ernest G.; Theoret, Yves;, Assignee: Hopital Sainte-Justine (Montreal, CA) |
Production of peptides in plants as viral coat protein fusions
What is claimed is: 1. A virion particle comprising a coat protein of a Tobamovirus and a fusion protein of the coat protein and a foreign protein. 2. A process for systemically expressing a fusion pr... Read More
Inventors: Turpen, Thomas H.; Reinl, Stephen J.; Grill, Laurence K.;, Assignee: Large Scale Biology Corporation (Vacaville, CA) |
Macrolide antibiotics
OF THE INVENTION The following reaction Schemes illustrate the preparation of the compounds of the present invention. Unless otherwise indicated a, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.s... Read More
Inventors: Kaneko, Takushi;, Assignee: Pfizer Inc. (New York, NY) |
Processes, apparatus and compositions for characterizing nucleotide sequences based on K-tuple analysis
The aforementioned and other objects are attained by the invention, which provides in one aspect a process for characterizing a sample of nucleic acid by contacting it, or portions thereof, with of pl... Read More
Inventors: Lopez-Nieto, Carlos Eduardo; Nigam, Sanjay Kumar;, Assignee: Brigham and Women's Hospital (Boston, MA) |
Variant of LAV viruses
In accordance with this invention, a new virus has been discovered that is responsible for diseases clinically related to AIDS and that can be classified as a LAV-1 virus but that differs genetically ... Read More
Inventors: Alizon, Marc; Sonigo, Pierre; Wain-Hobson, Simon; Montagnier, Luc;, Assignee: Institut Pasteur (Paris, FR) |
Anti-arthritic preparation
OF THE INVENTION The term "arthritis" relates generally to a class of disorders characterized by inflammation of joints, significant members of this class being rheumatoid arthritis and osteoarthriti... Read More
Inventors: Lapin, Alfred R.;, Assignee: |
Complexes of technetium-99m with propylene amine oximes
We claim: 1. A lipophilic macrocyclic complex, useful as a diagnostic radiopharmaceutical, of technetium-99m with a propylene amine oxime ligand having the formula: ##STR9## said complex being in the ... Read More
Inventors: Canning, Lewis R.; Nowotnik, David P.; Neirinckx, Rudi D.; Piper, Ian M.;, Assignee: Amersham International plc (Bucks, GB2) |
.sup.99m Tc labeled liposomes
Stable .sup.99m Tc-labeled liposomes and .sup.99m Tc labeled liposome-encapsulated protein and their novel method of preparation are the subject of the present invention. The method of preparation res... Read More
Inventors: Phillips, William T.; Klipper, Robert W.; Timmons, James H.; Rudolph, Alan S.;, Assignee: Board of Regents, The University of Texas System (Austin, TX); The United States of America as represented by the Secretary of the Navy (Washington, DC) |
New multifunctional ligands for potential use in the design therapeutic or diagnostic radiopharmaceutical imaging agents
OF THE INVENTION The present invention provides a class of diagnostic and therapeutic compounds generally comprising phosphinimine ligands complexed with a transition metal. The complexes have high i... Read More
Inventors: Katti, Kattesh V.; Volkert, Wynn A.; Ketring, Alan R.; Singh, Prahlad R.;, Assignee: Curators of the University of Missouri (Columbia, MO) |
Method of reducing immunogenicity
I claim: 1. A method of reducing immunogenicity of avidin, comprising the step of coupling the avidin with a carbohydrate polymer. 2. The method of claim 1, wherein the carbohydrate polymer is a polys... Read More
Inventors: Goldenberg, David M.;, Assignee: Immunomedics, Inc. (Morris Plains, NJ) |
Gene Therapy 
