Detection and therapy of lesions with biotin/avidin-metal chelating protein conjugates
We claim: 1. In a method for targeting a diagnostic or therapeutic metal ion to a lesion in a patient, comprising the steps of: (a) administering by parenteral injection a biotinylated targeting conju... Read More
Inventors: Goldenberg, David Milton; Griffiths, Gary L.; Hansen, Hans J.;, Assignee: Immunomedics, Inc. (Morris Plains, NJ) |
Lymphatic delivery composition
We claim: 1. A composition capable of delivering an active agent to the lymphatic system comprising a plurality of colloidal particles having an active agent associated with each particle, wherein the... Read More
Inventors: Davis, Stanley S.; Illum, Lisbeth; Christy, Nicola; Moghimi, Moein;, Assignee: Danbiosyst UK Limited (Nottingham, GB) |
Biocompatible microcapsules
This invention for the first time demonstrates the use of water soluble non-ionic polymers such as PEO to create resistance to cell adhesion on the surface of microcapsules. This invention provides a ... Read More
Inventors: Hubbell, Jeffrey A.; Sawhney, Amarpreet S.;, Assignee: The Board of Regents, The University of Texas System (Austin, TX) |
Composotions and methods for radiographic imaging
The present invention is a micellar iodine-containing block copolymer (MICBC) useful as a radiographic imaging agent. These micelle-forming block copolymers include a hydrophilic polymer linked to a ... Read More
Inventors: Torchilin, Vladimir P.; Trubetskoy, Vladimir S.; Wolf, Gerald L.; Gazelle, G. Scott;, Assignee: The General Hospital Corporation (Boston, MA) |
Biocompatible microcapsules
This invention for the first time demonstrates the use of water soluble non-ionic polymers such as PEO to create resistance to cell adhesion on the surface of microcapsules. This invention provides a ... Read More
Inventors: Hubbell, Jeffrey A.; Sawhney, Amarpreet S.;, Assignee: Board of Regents, The University of Texas System (Austin, TX) |
Adeno-associated viral vector-based methods and compositions for introducing an expression cassette into a cell
What is claimed is: 1. A method for introducing a functional expression cassette into a cell, said method comprising: (a) providing a population of first and second adeno-associated viral particles, w... Read More
Inventors: Nakai, Hiroyuki; Kay, Mark A.;, Assignee: The Board of Trustees of the Leland Stanford Junior University (Palo Alto, CA) |
Phospholipid- or lipid-linked glycosaminoglycan and process for producing the same
What is claimed is: 1. A process for producing a phospholipid- or lipid-linked glycosaminoglycan represented by the following formula (VI), ##STR122## or a salt thereof, which comprises the steps of: ... Read More
Inventors: Sakurai, Katsukiyo; Sugiura, Nobuo; Kimata, Koji; Suzuki, Sakaru;, Assignee: Seikagaku Kogyo Kabushiki Kaisha (Tokyo, JP) |
Inhibition of excessive phospholipase A.sub.2 activity and/or production by non-antimicrobial tetracyclines
The present invention provides a method for treating mammals suffering from conditions associated with excess phospholipase A.sub.2 activity and/or production which includes administering to the mamma... Read More
Inventors: Pruzanski, Waldemar; Golub, Lorne M.; Vadas, Peter; Greenwald, Robert A.; Ramamurthy, Nangavarum S.; McNamara, Thomas F.;, Assignee: The Research Foundation of State Univ. of New York (Albany, NY) |
Methods for treating arthritis using collagen type II, glucosamine chondroitin sulfate, and compositions
OF THE INVENTION The invention describes methods and compositions for the treatment of rheumatoid arthritis and osteoarthritis and other conditions that manifest cartilage degradation and inflammatio... Read More
Inventors: Sorgente, Nino; Nakamura, Robert M.;, Assignee: Immudyne, Inc. (Houston, TX) |
A3AR agonists for the treatment of inflammatory arthritis
The invention is described in the following SUMMARY with reference to a therapeutic method for the treatment of inflammatory arthritis. It should be noted that in addition to said therapeutic method, ... Read More
Inventors: Fishman, Pnina;, Assignee: Can-Fite Biopharma Ltd. Israel (Petach Tikva, IL) |
Nucleic acids encoding high molecular weight major outer membrane protein of moraxella
The present invention is directed towards the provision of purified and isolated major outer membrane protein of Moraxella catarrhalis and other Moraxella strains, having an apparent molecular mass of... Read More
Inventors: Sasaki, Ken; Harkness, Robin E.; Loosmore, Sheena M.; Klein, Michel H.;, Assignee: |
Saponin adjuvant compositions
What is claimed is: 1. A Quillaja saponaria saponin composition for eliciting an immune response in an organism, comprising a combination of a substantially pure QS-7 saponin and a substantially pure ... Read More
Inventors: Kensil, Charlotte A.;, Assignee: Aquila Biopharmaceuticals, Inc. (Framingham, MA) |
Quercetin derivatives and their medical usages
The invention claimed is: 1. A purified compound of formula I ##STR00002## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 are all or partly hydrogen atoms, or alkyl containing 1 to 5 carbon atoms; or phar... Read More
Inventors: Zhao, Yimin; Yang, Ming; Li, Yunfeng; Luan, Xinhui; Luo, Zhipu;, Assignee: Academy of Military Medical Sciences Institute of Pharmacology and Toxicology (Beijing, CN) N/A ( |
Islet cells from human embryonic stem cells
This invention solves the problem of generating large populations of human islet cells by showing how to efficiently differentiate them from pluripotent stem cells. It has been discovered that stem c... Read More
Inventors: Fisk, Gregory J.; Inokuma, Margaret S.;, Assignee: Geron Corporation (Menlo Park, CA) |
Neural thread protein gene expression and detection of alzheimer's disease
A need exists for a definitive diagnostic test which can be performed on individuals suspected of having, or being at risk for AD. The present invention satisfies such needs and provides further advan... Read More
Inventors: de la Monte, Suzanne; Wands, Jack R.;, Assignee: The General Hospital Coporation (Boston, MA) |
Method of detecting neurological disease or dysfunction
What is claimed is: 1. A method for detecting the presence of nPTP in a human subject, said method comprising: (a) contacting cerebrospinal fluid or brain tissue removed from said human subject with o... Read More
Inventors: Wands, Jack R.; Gross, Jerome; Ozturk, Mehmet; de la Monte, Suzanne;, Assignee: The General Hospital Corporation (Boston, MA) |
Metabolic pathway assay
This invention relates to an in vitro screening assay which identifies enzyme inhibitors. This invention allows for the simultaneous assay of many enzymes. The goal is to optimize the concentrations o... Read More
Inventors: Chabin, Renee M.; Kuo, David W.; O'Connell, John F.; Pompliano, David L.; Wong, Kenny K.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
MurC
What is claimed is: 1. An isolated polynucleotide segment comprising a first polynucleotide sequence or the full complement of the entire length of the first polynucleotide sequence, wherein the first... Read More
Inventors: Burnham, Martin Karl Russell; Wallis, Nicola Gail;, Assignee: SmithKline Beecham Corporation (Philadelphia, PA); SmithKline Beecham plc (Brentford, GB) |
Murf gene and enzyme of Pseudomonas aeruginosa
Polynucleotides and polypeptides of Pseudomonas aeruginosa MurF, an enzyme involved in bacterial cell wall biosynthesis are provided. The recombinant MurF enzyme is catalytically active in ATP-depende... Read More
Inventors: El-Sherbeini, Mohamend; Azzolina, Barbara;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Isoform specific inhibition for treatment of pain and reduction of anesthetic threshold
It is an object of the invention to provide a method of affecting nociception. It is an object of the invention to provide a catheter for treating pain. It is an object of the invention to provide a p... Read More
Inventors: Tao, Yuanxiang; Johns, Roger A.;, Assignee: Johns Hopkins University (Baltimore, MD) |
Liposomal transfection method
The object of the present invention is thus a method for transfecting a cell with a nucleic acid which comprises contacting the cell with a liposomal transfection composition comprising a nucleic acid... Read More
Inventors: Kinnunen, Paavo; Paukku, Tommi; Lauraeus, Satu; Huhtaniemi, Ilpo;, Assignee: |
Antihelminthic anthraquinones and method of use thereof
OF THE INVENTION All patents, patent applications, government publications, government regulations, and literature references cited in this specification are hereby incorporated herein by reference i... Read More
Inventors: Cichewicz, Robert H.; Nair, Muraleedharan G.; McKerrow, James H.;, Assignee: Board of Trustees of Michigan State University (East Lansing, MI) Regents of the University of California (Oakland, CA) |
Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
The invention is directed to a new method of inducing viral mutagenesis which is useful in cell culture as well as in therapy. This method is significantly advantageous in that it is one useful again... Read More
Inventors: Loeb, Lawrence A.; Mullins, James I.;, Assignee: University of Washington (Seattle, WA) |
2'-Fluoronucleosides
OF THE INVENTION The invention as disclosed herein is a compound, method and composition for the treatment of HIV, hepatitis (B or C), or abnormal cellular proliferation, in humans or other host anim... Read More
Inventors: Schinazi, Raymond F.; Liotta, Dennis C.; Chu, Chung K.; McAtee, J. Jeffrey; Shi, Junxing; Choi, Yongseok; Lee, Kyeong; Hong, Joon H.;, Assignee: Emory University (Atlanta, GA); University of Georgia Research Foundation, Inc. (Athens, GA) |
Nucleoside compounds
Where the following terms are used in this specification, they are used as defined below. The terms "nucleoside" and "nucleoside analog compound" are interchangeable and refer to a compound composed ... Read More
Inventors: Ramasamy, Kanda S.; Wang, Guangyi; Lau, Johnson;, Assignee: |
Method for the treatment of Flaviviridea viral infection using nucleoside analogues
OF THE INVENTION In one embodiment, the viral infection is chosen from Flaviviridea viral infections. In one embodiment, the Flaviviridea viral infection is chosen from of Hepatitis C virus(HCV), bov... Read More
Inventors: Storer, Richard;, Assignee: BioChem Pharma Inc. (CA) |
Monocyclic L-nucleosides, analogs and uses thereof
Where the following terms are used in this specification, they are used as defined below. The term "nucleoside" refers to a compound composed of any pentose or modified pentose moiety attached to a s... Read More
Inventors: Ramasamy, Kandasamy; Tam, Robert; Averett, Devron;, Assignee: ICN Pharmaceuticals, Inc. (Costa Mesa, CA) |
Storage medium storing catalog information and corresponding audio data
It is an object of the present invention to provide a storage medium for storing catalog information to satisfy the above-described conditions. It is another object of the present invention to provide... Read More
Inventors: Ko, Jung-wan; Heo, Jung-kwon; Heo, Jae-hoon; Kang, Jung-seuk;, Assignee: Samsung Electronics Co., LTD (Suwon, KR) |
Nucleoside compounds and uses thereof
The present invention is directed to nucleoside analogs and related compounds, including their prodrugs and metabolites, and their therapeutic uses and synthesis. In one aspect of the invention, there... Read More
Inventors: Hong, Zhi; Girardet, Jean-Luc; Ramasamy, Kanda; Lau, Johnson;, Assignee: Ribapharm, Inc. (Costa Mesa, CA) |
Composition and method for inhibiting platelet aggregation
OF THE INVENTION This invention is provides a method of preventing or treating diseases or conditions associated with platelet aggregation. The method also provides a method of treating thrombosis. T... Read More
Inventors: Boyer, Jose L.; Olins, Gillian M.; Yerxa, Benjamin R.; Douglass, James G.;, Assignee: Inspire Pharmaceuticals, Inc. (Durham, NC) University of North Carolina (Chapel Hill, NC) |
Gene Therapy 
