Non-infectious HIV particles and uses therefor
The present invention relates to HIV mutant constructs comprising a mutant HIV genome which has an alteration of a nucleotide sequence critical for packaging the HIV RNA genome, and which, when expres... Read More
Inventors: Aldovini, Anna; Young, Richard A.; Feinberg, Mark B.; Trono, Didier; Baltimore, David;, Assignee: Whitehead Institute for Biomedical Research (Cambridge, MA) |
Non-infectious, replication-impaired, immunogenic human immunodeficiency virus type 1 retrovirus-like particles with multiple genetic deficiencies
What we claim is: 1. A genetically-engineered, non-infectious, non-replicating and immunogenic retrovirus-like particle comprising the gag, pol and env proteins of the human immunodeficiency virus whe... Read More
Inventors: Haynes, Joel; Klein, Michel Henri; Rovinski, Benjamin; Cao, Shi Xian;, Assignee: Connaught Laboratories Limited (North York, CA) |
Live genetically attenuated malaria vaccine
Here we show by reverse genetics that selected individual genes, exemplified by UIS3 (up-regulated in infective sporozoites gene 3) and UIS4, are essential for early liver stage development: uis3(-) a... Read More
Inventors: Kappe, Stefan H. I.; Matuschewski, Kai-Uwe C.; Mueller, Ann-Kristin;, Assignee: Seattle Biomedical Research Institute (Seattle, WA) Ruprecht-Karls-Universitat Heidelberg (Heidelberg, DE) |
Propargylethoxyamino nucleotides
OF THE PREFERRED EMBODIMENTS Reference will now be made in detail to the preferred embodiments of the invention, examples of which are illustrated in the accompanying drawings. While the invention wi... Read More
Inventors: Khan, Shaheer H.; Menchen, Steven M.; Rosenblum, Barnett B.;, Assignee: Applera Corporation (Foster City, CA) |
Pharmaceutical colloidal preparation useful in the treatment of respiratory diseases
The invention claimed is: 1. An aerosolized colloidal suspension that is active for the treatment of at least one of respiratory diseases of the upper airways, bronchial asthma, chronic obstructive br... Read More
Inventors: Petrigni, Giuseppe; Allegra, Luigi;, Assignee: |
Phosphate-binding polymers for oral administration
The invention relates to the discovery that a class of anion exchange polymers have improved phosphate binding properties. In general, the invention features a method of removing phosphate from a pati... Read More
Inventors: Holmes-Farley, Stephen Randall; Manderville, III, W. Harry; Whitesides, George M.;, Assignee: Genzyme Corporation (Cambridge, MA) |
Recombinant poxvirus host range selection system
OF THE INVENTION The invention is directed to a selection system for poxvirus recombinants, particularly vaccinia recombinants, and for the cloning and expression of an open reading frame in poxvirus... Read More
Inventors: Paoletti, Enzo;, Assignee: Health Research Inc. (Albany, NY) |
Herpes simplex virus strains
OF THE INVENTION DEFINITIONS As used herein, including the claims appended hereto, the following terms are defined as follows: "Herpes simplex virus" (HSV) means both type 1 HSV and type 2 HSV. "None... Read More
Inventors: DeLuca, Neal A.;, Assignee: University of Pittsburgh of the Commonwealth System of Higher Education (Pittsburgh, PA) |
Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
Applicants have discovered that tumor formation in a patient can be treated or prevented by administering to the patient an antigen-presenting cell(s) that is loaded with antigen encoded in RNA derive... Read More
Inventors: Nair, Smita K.; Boczkowski, David J.; Gilboa, Eli;, Assignee: Duke University (Durham, NC) |
Methods of modulating an immune response to antigen, and cells for use in the method
What is claimed is: 1. A method of inducing an immune response in a mammal to a selected antigen, the method comprising administering to the mammal a composition comprising a cell comprising said sele... Read More
Inventors: Segal, Andrew H.;, Assignee: Whitehead Institute for Biomedical Research (Cambridge, MA) |
Ketogulonigenium endogeneous plasmids
OF THE INVENTION Unless otherwise indicated, all nucleotide sequences determined by sequencing a DNA molecule herein were determined using an automated DNA sequencer (such as the ABI Prism 3700). The... Read More
Inventors: D'Elia, John; Stoddard, Steven F;, Assignee: Archer-Daniels-Midland Company (Decatur, IL) |
Cleavable conjugates for the delivery and release of agents in native form
OF THE INVENTION Prior to setting forth the invention, it may be helpful to an understanding thereof to set forth definitions of certain terms to be used hereinafter. Targeting molecule--any molecule... Read More
Inventors: Hylarides, Mark D.; Srinivasan, Ananthachari; Fitzner, Jeffrey N.; Vrudhula, Vivekananda M.;, Assignee: NeoRx Corporation (Seattle, WA) |
Screening assay for the detection of DNA-binding molecules
OF THE INVENTION I. Definitions: Adjacent is used to describe the distance relationship between two neighboring sites. Adjacent sites are 20 or less bp apart, and can be separated by any fewer number... Read More
Inventors: Edwards, Cynthia A.; Cantor, Charles R.; Andrews, Beth M.; Turin, Lisa M.;, Assignee: Genelabs Technologies, Inc. (Redwood City, CA) |
HCV anti-core monoclonal antibodies
What is claimed is: 1. A hybridoma cell line corresponding to the ATCC number selected from the group consisting of PTA-3799, PTA-3800, PTA-3801, PTA-3802, PTA-3803, PTA-3804, PTA-3805, PTA-3806, PTA-... Read More
Inventors: Bahl, Chander;, Assignee: Ortho-Clinical Diagnostics, Inc. (Rochester, NY) |
Canine IL-4 immunoregulatory proteins and uses thereof
OF THE INVENTION The present invention provides for isolated canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleuk... Read More
Inventors: Sim, Gek-Kee; Yang, Shumin; Dreitz, Matthew J.; Wonderling, Ramani S.;, Assignee: Heska Corporation (Fort Collins, CO) |
Anti-cancer and wound healing compounds
What is claimed: 1. A method for decreasing expression of vascular endothelial growth factor that comprises contacting a cell comprising a gene for vascular endothelial growth factor with an effective... Read More
Inventors: Quirk, Stephen; Weart, Ilona F.;, Assignee: Kimberly-Clark Worldwide, Inc. (Neenah, WI) |
Process for the preparation of D-asparagine derivatives
OF THE INVENTION Surprisingly, it has now been found, that enzyme inactivation during the preparation of asparagine ester derivatives could be overcome by employing an organic solvent. (The effect of... Read More
Inventors: Iding, Hans; Rogers-Evans, Mark; Wirz, Beat;, Assignee: Basolea Pharmaceutica AG (Binningen, CH) |
Method for L-threonine production
OF INVENTION The present invention will be described in greater detail by means of the following examples. The following examples are for illustrative purposes and are not intended to limit the scope... Read More
Inventors: Noh, Kap-Soo; Kim, Yeong-Chul; Park, Jae-Yong; Kim, Dai-Chul; Lee, Jin-Ho; Ok, Seung-Han;, Assignee: Cheil Jedang Corporation (KR) |
Method of treating infectious bursal disease virus infections
The present invention is based on our ongoing efforts to characterize Viral Neutralizing Factor (VNF). During this research, the active component of prior preparations of VNF was unexpectedly found to... Read More
Inventors: Whitfill, Craig E.; Thoma, John A.; Fredericksen, Tommy L.; Tyczkowski, Julius K.; Thaxton, Jr., J. Paul;, Assignee: |
Marek's disease virus nucleotide sequence and methods of use
OF THE INVENTION The MDV genome is a linear 180 kilobase pair double stranded molecule consisting of two unique regions: a unique short region (US), and a unique long region (UL). Each of the unique ... Read More
Inventors: Schat, Karel A.; Ohashi, Kazuhiko; O'Connell, Priscilla H.;, Assignee: Cornell Research Foundation, Inc. (Ithaca, NY) |
In ovo immunization of avian embryos with oil-emulsion vaccines
It is therefore an object of the present invention to provide a method of in ovo immunization of avian embryos. Another object of the present invention is to provide a method of in ovo immunization us... Read More
Inventors: Stone, Henry D.;, Assignee: The United States of America as represented by the Secretary of the (Washington, DC) |
Multivalent in ovo avian vaccine
As discussed previously, one of the most prevalent and economically destructive diseases of the poultry industry is Marek's disease (MD). It has been found that the turkey herpesvirus (HVT) vaccine c... Read More
Inventors: Sharma, Jagdev M.;, Assignee: Regents of the University of Minnesota (Minneapolis, MN) |
Avian polynucleotide formula
The invention therefore proposes to provide a multivalent vaccine formula which makes it possible to ensure vaccination against a number of pathogenic avian viruses. Another objective of the invention... Read More
Inventors: Audonnet, Jean-Christophe; Bouchardon, Annabelle; Riviere, Michel;, Assignee: Merial (Lyons, FR) |
Method of treatment
The present invention is based on our ongoing efforts to characterize Viral Neutralizing Factor (VNF). During this research, the active component of prior preparations of VNF was unexpectedly found to... Read More
Inventors: Whitfill, Craig E.; Thoma, John A.; Fredericksen, Tommy L.; Tyczkowski, Julius K.; Thaxton, Jr., J. Paul;, Assignee: University of Arkansas (Fayetteville, AR) |
Substituted tetracycline compounds as synergistic antifungal agents
OF THE INVENTION Although opportunistic systemic fungal infections have a high morbidity and mortality and their incidence is increasing, the art has yet to provide a safe, effective water soluble, s... Read More
Inventors: Draper, Michael; Nelson, Mark L.;, Assignee: Paratek Pharmaceuticals, Inc. (Boston, MA) |
Sterilization indicator test packs
OF THE INVENTION The sterilization indicators of this invention address a problem experienced with biological indicators that use enzymes to test the effectiveness of sterilization procedures, such a... Read More
Inventors: Witcher, Kelvin J.; Foltz, William E.; Chandrapati, Sailaja; Rosenlund, Thomas T.; Asmus, Robert A.; Lulich, Ronald G.;, Assignee: 3M Innovative Properties Company (St. Paul, MN) |
Bystander effect tumoricidal therapy by expressing an HSV-tk gene
It is therefore an object of the present invention to provide a effective method for gene transfer-based cancer treatment. It is a further object of the present invention to provide a method of using ... Read More
Inventors: Culver, Kenneth W.; Blaese, R. Michael;, Assignee: The United States of America as represented by the Secretary of the (Washington, DC) |
Neural cell adhesion protein nerve prosthesis
Having described the invention, what is claimed is: 1. In a process wherein the severed ends of the peripheral nerve of a living mammal, the function of which is to serve a muscle impaired by the brea... Read More
Inventors: Daniloff, Joanne K.;, Assignee: Louisiana State University (Baton Rouge, LA) |
Assay for Ribozyme target site
I claim: 1. A method for determining ribozyme target site accessibility and synthesis of a ribozyme, comprising the step of: contacting a DNA oligonucleotide complementary to the target RNA with said ... Read More
Inventors: McSwiggen, James A.;, Assignee: Ribozyme Pharmaceuticals, Inc. (Cleveland, OH) |
Gapped 2'-modified oligonucleotides
OF THE INVENTION In accordance with the objects of this invention, novel oligonucleotides and macromolecules that, at once, have increased nuclease resistance, increased binding affinity to complemen... Read More
Inventors: Cook, Phillip Dan;, Assignee: ISIS Pharmaceuticals, Inc. (Carlsbad, CA) |
Gene Therapy 
