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Home Heart Surgery Apparatus-and-methods-for-radiotherapy

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Details
Inventors: Lewis, Dewi M.; Dollimore, Lucinda A.; Powell, Nigel; McIntire, Gregory L.; Gustow, Evan; Snow, Robert A.;
Assignee: GE Healthcare Limited (Buckinghamshire, GB)
Primary Examiner: Ganey; Steven J.
Assistant Examiner:
Attorney, Agent or Firm: Chisholm; Robert F.

The invention provides the use of a radiation source which is a low energy X-ray emitter, e.g. with an energy of emission of the principal photon in the range of 20 to 100 keV, preferably 20 to 40 keV and with a half life of 10 to 100 days, preferably 15 to 70 days, for the treatment of restenosis. Suitable radioisotopes include palladium-103, dysprosium-159, samarium-145, cadmium-109, ytterbium-169 and preferably iodine-125. High activity radioactive bodies and sources comprising such radioisotopes, and methods for the manufacture of such sources, are also disclosed.

DETAILED DESCRIPTION What is claimed is: 1.
A radioactive body suitable for temporary or permanent implantation in a mammal for use in brachytherapy containing a low energy X-ray emitter which emits low energy X-rays at an activity equivalent to iodine-125 in the range of about 74 to 185 GBq (about 2 Ci to 5 Ci).
2.
A radioactive body as claimed in claim 1 wherein the low energy X-ray emitter is iodine-125, palladium-103, dysprosium-159, samarium-145, cadmium-109 or ytterbium-169.
3.
A radioactive body as claimed in claim 1 wherein the low energy X-ray emitter is iodine-125 or palladium-103.
4.
A radioactive body as claimed in claim 1 which is a sealed source.
5.
A radioactive body as claimed in claim 1 which is a seed.
6.
A radioactive body as claimed in claim 1 which comprises one or more radioactive sources.
7.
A radioactive body as claimed in claim 6 wherein the radioactive source comprises a radioisotope and one or more supports.
8.
A radioactive body as claimed in claim 7 wherein the support is a bead, rod, wire or filament.
9.
A radioactive body as claimed in claim 7 wherein the support is a bead of ion exchange resin, graphite, ceramic, zeolite, any form of carbon or another porous material.
10.
A radioactive body as claimed in claim 1 wherein the X-ray emitter is iodine-125, and wherein the iodine-125 is present in the form of an insoluble metal iodide on the surface of a suitable support.
11.
A radioactive body as claimed in claim 10 wherein the support comprises a metal chosen from silver, copper, palladium, thallium, gold, lead or platinum.
12.
A radioactive source as claimed in claim 10 wherein the metal is silver.
13.
A radioactive body as claimed in claim 1, which is cylindrical and which contains a plurality of radioactive sources, wherein each source comprises a radioisotope and a support in the shape of a bead, rod, wire or filament, characterised in that the sources at the ends of the cylindrical body have higher activity than the sources at the centre of the cylindrical body, such that the radiation field around the radioactive body is substantially cylindrically uniform



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