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Apparatus for continuously sampling plasma
| Details |
Inventors: Parl, Fritz F.; Bradley, Charles A.; Benge, Herman; Black, David L.;
Assignee: Vanderbilt University (Nashville, TN)
Primary Examiner: Hinenburg; Max
Assistant Examiner:
Attorney, Agent or Firm: Tilton, Fallon, Lungmus
A method and apparatus for continuously sampling plasma are disclosed. The method of the present invention comprises removing blood from the patient, separating a substantially small portion of plasma, and returning the blood to the patient. The removing, separating, and returning steps are performed continuously and simultaneously with each other. The apparatus of the present invention relates to a double-lumen cannula or venipuncture needle for the removal and returning of blood to the patient at the same site. |
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DETAILED DESCRIPTION The present invention provides a method and apparatus for continuously sampling plasma in a closed system for diagnostic purposes.
The whole blood is removed from the patient and the plasma separated from the removed blood wherein the removed cellular elements of the blood are returned to the patient at the same site.
The removing, separating, and returning steps of the process are performed substantially continuously and simultaneously with each other.
Further, the present invention provides a venipuncture cannula consisting of two components (a) a double-lumen body of a resilient material, i.
e.
plastic, and (b) a solid stainless steel core within each passageway of said double-lumen body.
After penetrating the skin by the piercing points of the rigid core and positioning the needle in a blood vessel, the rigid core is retracted thereby allowing prolonged placement of the double-lumen cannula in the vessel without injuring the vessel wall due to the presence of the resilient plastic sheath contacting the vessel wall.
After removal of the metal core, flexible tubing may be connected to the cannula for transporting blood.
The passageways are separate and distinct in the cannula for blood leaving and returning to the blood vessel.
In another aspect, the present invention provides a loop of sterile tubing which is filled with Ringer's solution or isotonic saline to be connected to the inlet and outlet ports of the double-lumen cannula.
Therefore, by means of a pump, the present invention provides a system for unidirectional flow of blood from the patient through the inflow lumen into the tubing and back through the outflow lumen of the double-lumen sheath at the same vascular site into the patient.
More particularly, the present invention provides a method and apparatus for continuously sampling plasma for diagnostic purposes in a system closed with reference to cellular components of blood.
A substantially small portion of plasma is removed from the blood by filtration through a non-wettable plastic membrane filter in the side of the tubing thereby permitting collection of the plasma in collecting means, preferably on solid phase reagent strips brought into immediate contact with the tubing, while retaining the essential body of plasma and all blood cells in the tubing
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