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Disposable cell culture chamber with remote access
| Details |
Inventors: Frisch, Eldon E.; Kantrowitz, Adrian; Freed, Paul S.;
Assignee: L. Vad Technology, Inc. (Pontiac, MI)
Primary Examiner: Pellegrino; Stephen C.
Assistant Examiner:
Attorney, Agent or Firm: Basile and Hanlon
A combination is provided of a percutaneous lead designed for implantation in the human body, which lead has a surface which is adapted to pass through and be exposed to the dermis of a patient when the device is implanted. Said surface is adapted to receive the growth of a cultured autogenous fibroblast coating on an etched, nanoporous surface. A liquid tight sealed removable, disposable chamber encloses said surface, said chamber being provided with openings for introduction therein of finely divided living dermal tissue suspended in a liquid carrier, thus providing a means for formation of the cultured surfaces which can be easily handled. The disposable chamber is removed and discarded at the time of surgery. |
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DETAILED DESCRIPTION OF THE INVENTION The invention is illustrated in connection with the same type of percutaneous access device as that disclosed in Freed U.
S.
Pat.
No.
4,004,298 and Kantrowitz et al U.
S.
Pat.
No.
4,634,422.
The invention is, however, applicable to percutaneous lead devices of other types or shapes.
The peridermal component of a percutaneous access device or lead is denoted generally in the drawings by numeral 10.
Component 10 includes a base portion 11, integral with and extending upwardly from which is an extension 12 adapted to be implanted immediately beneath the skin of a patient.
Extension 12 is provided with a nanoporous portion 14 which is formed by etching or other means.
Cells cultured from a small specimen of the patient's (or animal's) skin become adherent to the nanoporous surface and form a continuous fibroblast cell layer over the nanoporous area.
Membranes of fibroblast cells in contact with the nanoporous surface form within and fill the nanopores, which typically average two nanopores per cell.
When the cell-cultured peridermal component is implanted peridermally in humans or animals in a preformed fibrous tissue capsule formed by prior subdermal implantation of an identically shaped, nonporous solid implant, the cell-cultured fibroblsts on the nanoporous component become continous with the fibroblasts of the fibrous tissue capsule.
As the dermis heals around the percutaneous conduit 18, the dermis also grows downward as in marsupialization until it contacts the fibroblast layer adherent to the nanoporous surface of extension 12.
The dermis then joins or heals to the fibroblast layer to form a bacteria-proof seal, similar to the juncture between skin and scar, such as scar left from surgical incision.
Thus the dermis becomes firmly united with the exterior surface of extension 12.
Extension 12 is provided with an end closure 16, through which extends a conduit 18.
Conduit 18 may merely be a removable plug or cover to expose a connection to which an external conduit can be attached or removed as needed
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Heart Surgery 
