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| Drain cannula |
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Implantation materials
| Details |
Inventors: Kurumatani, Hajimu; Kataoka, Hiroshi; Yamada, Kyoko;
Assignee: Toray Industries, Inc. (JP)
Primary Examiner: Brittingham; Debra S.
Assistant Examiner:
Attorney, Agent or Firm: Miller; Austin R.
The present invention is implantation materials comprising an anti-thrombogenic material contained in the surface in contact with blood, of a porous substrate with its voids filled with denatured albumin or a biodegradable polyester. Since they are excellent in anti-thrombogenic property and allow the positive introduction of cells into the implantation materials, they can prevent thrombogenesis for long periods of time. Especially even if they are used as artificial small diameter blood vessels of less than 6 mm in inner diameter, they show excellent patency. |
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DETAILED DESCRIPTION We claim: 1.
An anti-thrombogenic implantation material consisting essentially of a layer of a porous substrate made of individual fibers having voids filled with a biodegradable polymer and a layer of an anti-thrombogenic agent formed onto a surface portion formed by said substrate and said biodegradable polymer, wherein said porous substrate has a coefficient of water permeability of 500 to 5,000 ml/cm.
sup.
2 /min.
120 mmHg and said biodegradable polymer has a degradation period that is shorter than that of said anti-thrombogenic agent of said layer.
2.
An anti-thrombogenic implantation material according to claim 1, wherein said biodegradable polymer is a biodegradable polyester.
3.
An anti-thrombogenic implantation material according to claim 2, wherein the biodegradable polyester is selected from the group consisting of polylactic acid, polyglycolic acid, polyhydroxylactic acid, polycaprolactone, polyethylene adipate, polydioxanone and copolymers of the foregoing.
4.
An anti-thrombogenic implantation material according to claim 1, wherein said biodegradable polymer is denatured albumin.
5.
An anti-thrombogenic implantation material according to claim 4, wherein said denatured albumin is crosslinked by a treatment selected from the group consisting of heat treatment, chemical crosslinking agent and a combination of heat treatment and a chemical crosslinking agent.
6.
An anti-thrombogenic implantation material according to claim 1, wherein an additive selected from the group consisting of a basic protein, a polypeptide and both of a basic protein and a polypeptide is added to the biodegradable polymer.
7.
An anti-thrombogenic implantation material according to claim 1, wherein an additive selected from the group consisting of a basic protein, a polypeptide and both of a basic protein and a polypeptide is added to the anti-thrombogenic agent layer.
8.
An anti-thrombogenic implanation material according to claim 1, wherein the degradation period of the biogradable polymer is 3 to 400 days when said material is a sheet 10 mm square
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Heart Surgery 
