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Home Heart Surgery Intravascular-catheter-with-infusion-array

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 Intravascular catheter with infusion array

Details
Inventors: Kaplan, Aaron V.; Kermode, James R.; Klein, Enrique J.;
Assignee: Localmed, Inc. (Palo Alto, CA)
Primary Examiner: McDermott; Corrine M.
Assistant Examiner:
Attorney, Agent or Firm: Townsend and Townsend and Crew LLP

An intravascular catheter provides means for infusing an agent into a treatment site in a body lumen and means for deploying the infusing means adjacent the treatment site which operate independently of one another. In a first embodiment, a flexible catheter body has an expansion member attached to its distal end in communication with an inflation passage, and an infusion array disposed about the expansion member in communication with one or more delivery passages. In a second embodiment, the infusion array is a separate component and slidably received over the expansion member, which may be a balloon dilatation catheter. In both embodiments, the infusion array includes a plurality of delivery conduits having laterally oriented orifices. The delivery conduits may be extended radially from the catheter body to contact a treatment site by expanding the expansion member with an inflation fluid. An agent may be introduced into the delivery passages and infused into the treatment site through orifices in the delivery conduits. The expansion member may be expanded for dilatation of the lumen before, during, or after infusion.

DETAILED DESCRIPTION The present invention provides an intravascular catheter for administering a therapeutic agent to a treatment site in the wall of a vessel.
The catheter will have particular usefulness in treating arterial stenoses in conjunction with angioplasty, but will have further application in treating diseases affecting other body organs, such as the prostate, biliary ducts and genital-uretal-system.
The catheter of the present invention is particularly advantageous over known devices because it permits deployment of the delivery mechanism adjacent to the treatment site independently of the delivery of the agent to the treatment site.
The invention thereby facilitates dilatation to be performed with or without infusion of an agent, as well as infusion of an agent before, during, after, or without dilatation.
The catheter of the present invention further permits directional infusion of one or more agents within a body lumen.
Moreover, the catheter improves the effectiveness of drug treatment by infusing the agent at pressures sufficient to achieve penetration into the adventitial layer of the organ.
In a specific embodiment, an apparatus for infusing an agent to a treatment site in a body lumen comprises a catheter body having a distal end, a proximal end and first and second passages therebetween; a guidewire extending from the distal end of the catheter body; an expansion member attached to the catheter body near the distal end, the interior of the expansion member being in fluid communication with the first passage; and an infusion array in communication with the second passage and disposed adjacent a lateral surface of the expansion member so as to be deployable adjacent to the treatment site by deployment of the expansion member, wherein the infusion array is operable for infusing an agent to the treatment site independently of deployment of the expansion member.
In a preferred embodiment, the infusion array comprises at least a first tubular delivery conduit having a plurality of orifices on a surface thereof and an axial passage which is in communication with the second passage in the catheter body



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