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Home Heart Surgery Means-and-method-for-the-treatment-of-migraine-headaches

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 Means and method for the treatment of migraine headaches

Details
Inventors: Fischell, Robert E.; Fischell, David R.; Upton, Adrian R. M.;
Assignee: NeuraLieve, Inc. (Glenelg, MD)
Primary Examiner: Winakur; Eric F.
Assistant Examiner: Cadugan; Joseph A
Attorney, Agent or Firm:

Disclosed is a means and method for the treatment of migraine headaches. Patients who have migraine headaches typically have a band of excited brain neurons that are a precursor of the headache. By placing an intense alternating magnetic field onto a certain region of the brain, an electrical current can be generated in the cerebral cortex that can depolarize these excited brain neurons. This procedure can stop a migraine headache in some patients or at least decrease its severity. The device to perform this function can be called a "magnetic depolarizer". The magnetic depolarizer can be placed in some headgear such as a bicycle helmet in order to place the magnetic field at the correct location relative to the patient's cerebral cortex. This technique can be particularly valuable for patients who have a perceptible aura that occurs prior to the onset of a migraine headache. A visual aura caused by the progression of an excited band of neurons in a patient's occipital lobe, which aura occurs 20 to 30 minutes prior to the onset of head pain, would be particularly well treated by means of the magnetic depolarizer.

DETAILED DESCRIPTION This invention is a means and method for the treatment of migraine headaches for those patients who experience a distinct aura before the actual occurrence of the symptoms of the migraine headache.
It is estimated that approximately 40% of all migraine patients have a distinct aura that is a precursor of a migraine headache.
Approximately half of these patients have a visual aura that typically begins as a small pattern of scintillating colored lights that have the appearance of wiggling worms.
Over a time period of between 20 and 30 minutes, the pattern enlarges until it occupies nearly the entire visual field.
During this time period, the patient might also completely lose part of his visual field.
At the end of this visual aura, most migraine patients have a severe headache that is often accompanied by other symptoms such as nausea, vomiting and other unpleasant feelings.
Many migraine patients who don't have a visual aura have some other precursor of a migraine that can be perceived from minutes to hours before the actual start of the headache.
The visual aura is a result of the spatial progression of a band of brain cells that are excited in that band across one half of the brain's occipital lobe.
This band moves in an anterior direction at the rate of approximately 2-5 mm per minute.
It is this excited band of neurons of the brain that produces the scintillating colored lights that are perceived by the patient as an aura that is a precursor of a migraine headache.
Behind this leading band of excited neurons, a spreading region of neurons with depressed electrical excitability occurs.
This phenomenon is known as "the spreading depression of Leao".
It is believed that if the advancing band of excited neurons can be stopped before the aura has completed its 20 to 30 minute time duration period, the migraine headache will not occur.
One way to stop such an advancing band of excited brain neurons would be by imposing a high enough electric current through these neurons so that they become depolarized



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