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Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney by infusion of a vasodilator
| Details |
Inventors: Levin, Howard R.; Gelfand, Mark;
Assignee: Intellicardia, Inc. (New York, NY)
Primary Examiner: Criares; Theodore J.
Assistant Examiner: Kim; Jennifer
Attorney, Agent or Firm: Nixon & Vanderhye P.C.
A method for treating congestive heart failure (CHF) has been developed that restores kidney renal functions by artificial vasodilation of at least one kidney. A vasodilator drug is locally delivered to the kidney via a kidney perfusion catheter. The drug can be mixed with the patient's blood, saline or other suitable solvent and the mixture directly applied to the kidney through the catheter. The restoration of kidney function assists the heart by removing excess fluid, urine and toxin from the patient, and by normalizing the patient's renin-angiotensin system and other neurohormonal substances. The method is applicable to treat chronic and acute CHF. |
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DETAILED DESCRIPTION OF A PREFERRED EMBODIMENT OF THE INVENTION FIG.
1 shows one embodiment of the proposed therapy where the vasodilator drug is used in combination with the apparatus for perfusion of the kidney with a percutaneous catheter.
A method and apparatus for isolated perfusion of a kidney with a catheter is described more fully in the co-owned and related U.
S.
patent application Ser.
No.
09/454,605, filed Dec.
7, 1999, for a "Kidney Perfusion Catheter"; and U.
S.
patent application Ser.
No.
09/501,234, filed Feb.
10, 2000, for a "Method and Apparatus for Treatment of Congestive Heart Failure by Improving Perfusion of the Kidney", both of which applications are still pending.
The disclosures of both of these patents are incorporated by reference.
FIG.
1 is a schematic diagram of a patient 1 having a heart 2, an aorta 3 a femoral artery 4, a kidney 5, and a renal artery 6.
A perfusion catheter assembly 8 is inserted at the patient's groin 13 and into the femoral artery.
The catheter, e.
g.
, introducer catheter 14, is maneuvered by a surgeon through the femoral artery, into the aorta to the entrance (ostium 12) of one of the renal arteries 6.
The distal end of catheter may include a sealing balloon 16 to block off the entrance of the renal artery and position the catheter at the ostium.
Similarly, a positioning balloon 17 may position the catheter within the arota.
Blood enters a proximal end 9 of the catheter from a blood pump 10 and flows from the distal end 11 of the catheter (which may include small diameter catheter tip 15 that extends past the ostium and into the renal artery) directly into the renal artery.
Upon exiting the pump, blood is mixed with the fluid containing the vasodilator drug.
A drug coupling device 24 connects the drug dispersing apparatus 18 to the proximal end 9 of the catheter, such that the drug can be infused into the blood flowing from the pump 10 to the catheter.
A known dose of the drug is preloaded into an automatic syringe pump 20 and infusion syringe 21
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