 Minimally invasive direct cardiac massage device and method |
| The cardiac pumping device and method presented below allows for direct cardiac massage in a ... |
|
| Heater door mechanism for infant warming apparatus |
| Accordingly, the present invention relates to an infant care apparatus that combines the functions ... |
|
| Prosthetic heart valve with increased valve lumen |
| A heart valve prosthesis for implantation in the heart of a patient includes a valve housing or ... |
|
| Method of making hollow elastomeric bodies |
| In accordance with the invention, an annular hollow body having an integral, sharp-cornered flange ... |
|
| Artificial heart valve made by vacuum forming technique |
| OF THE PREFERRED EMBODIMENTS Reference is now made to the accompanying drawings wherein like parts ... |
|
| Method of making a blood pumping membrance for artificial ventricles |
| OF THE INVENTION FIG. 1 shows an artificial ventricle 10 which may be used as a ventricle assist ... |
|
| Device and method for an IAB assist with multiple balloons |
| The present invention involves the use of two or more intra-aortic balloons which may be of ... |
|
| Apparatus and method for the percutaneous insertion of a pediatric intra-aortic balloon catheter |
| Accordingly, it is an object of the invention to produce a pediatric intra-aortic balloon catheter ... |
|
| Cardiac assist system and method thereof |
| Briefly, and in general terms, the present invention is directed to a system and method for ... |
|
| Automated system for the radiation treatment of a desired area within the body of a patient |
| The present invention comprises an automated catheter based radiation delivery system and its ... |
|
|
Surface-modifying copolymers having cell adhesion properties
| Details |
Inventors: Riffle, Judy S.;
Assignee: Thoratec Laboratories, Inc. (Berkeley, CA)
Primary Examiner: Sergent; Rabon
Assistant Examiner:
Attorney, Agent or Firm: Fish and Richardson P.C.
A hemocompatible surface-modifying additive is provided for modifying polyurethane or polyurethane urea substrates. The additive has a polyurethane or polyurethane urea hard block or an alternative block which is miscible with the poly(urethane) or poly(urethane-urea) base polymer, a polysiloxane hydrophobic soft block, an optional hydrophilic spacer and a peptide selected from the group consisting of Arg-Gly-Asp, X-Arg-Gly-Asp, Arg-Gly-Asp-X and X-Arg-Gly-Asp-X', wherein X and X' are amino acids. |
|
DETAILED DESCRIPTION What is claimed is: 1.
A hemocompatible surface-modifying copolymer additive for modifying poly(urethane), poly(urethane urea) or polystyrene base polymers, said additive having the formulas ##STR13## wherein A is a polyurethane, poly(urethane urea) or polystyrene hard block; B is a polysiloxane hydrophobic soft block; C is an optional hydrophilic spacer; D is a peptide selected from the group consisting of the sequence -Arg-Gly-Asp, -X-Arg-Gly-Asp, Arg-Gly-Asp-X and -X-Arg-Gly-Asp-X', wherein X and X' are any amino acid; and n, v, m and p are each independently an integer greater than 0 up to about 500.
2.
An additive according to claim 1 wherein X is Gly.
3.
An additive according to claim 1 wherein said spacer is a polyalkylene oxide.
4.
An additive according to claim 1 wherein said additive is of the formula ##STR14## 5.
An additive according to claim 1 wherein said additive is of the formula ##STR15## 6.
An additive according to claim 1 wherein said additive is of the formula ##STR16## 7.
An additive according to claim 1 wherein said additive is of the formula ##STR17## 8.
A copolymer additive according to claim 1 wherein n, v, m, and p are each independently an integer greater than 0 up to 100.
9.
A blood-contacting device comprising a blood-contacting surface of a base polymer and an additive according to claim 1 of the formula: ##STR18## or mixtures of two or more different additives of said formulas.
10.
A method of modifying a poly(urethane) substrate to impart a hemocompatible surface thereto, comprising the step of incorporating into said substrate an effective hemocompatible surface-active amount of an additive according to any one of claims 1 through 7.
11.
A method of modifying a poly(urethane urea) substrate to impart a hemocompatible surface thereto, comprising the step of incorporating into said substrate an effective hemocompatible surface-active amount of an additive according to any one of claims 1 through 7.
Description:
FIELD OF THE INVENTION The present invention is directed to novel block copolymers which are hemocompatible surface-modifying additives for modifying polyurethane, poly (urethane urea), polystyrene or polystyrene-containing elastomer substrates
|
| Related patents |
|
|
System for administering a combination of therapies to a body lumen
The present invention is aimed at using an implantable medical device to effect a desired treatment, which is often, but not necessarily, the prevention of restenosis. S...
|
|
|
Piezoelectric pumps
The present invention is directed to an electro-motional device, specifically piezoelectric pumps. More specifically, the present invention is directed to various ...
|
|
|
Magnetically driven axial-flow pump
According to the present invention, there is provided a magnetically driven axial-flow pump comprising (i) an electromagnet unit arranged about the periphery of a pipe, (...
|
|
|
Electric motor driven blower assembly with integral motor cooling duct
The subject invention provides an alternative structure for providing an integral motor cooling air passage, with better sealing and higher tolerance at the joint. In ...
|
|
|
Tongue-airway appliance
The present invention provides an intra-oral appliance in the form of a tongue-airway functional appliance which restores/encourages training of the tongue, which ...
|
|
|
Method and apparatus for preventing air embolisms
One aspect of the present invention involves providing a method of preventing air embolisms. The method comprises the steps of: (a) providing a fluid source in ...
|
|
|
Isolation chamber
The present invention provides an isolation chamber that provides containment for a contaminated patient. Advantageously, embodiments of the present invention are usable ...
|
|
|
Flextensional output actuators for surgically implantable hearing aids
This invention relates to devices and methods relating to implantable hearing aids for placement within a middle ear or the inner ear. In particular, the invention ...
|
|
|
Self-expanding defect closure device and method of making and using
The present invention provides a self-expanding defect closure device that overcomes the many drawbacks and disadvantages of prior devices. The devices of the present ...
|
|
|
Method and apparatus for treating pain with therapeutic magnets
What is claimed is: 1. A method of arranging a plurality of therapeutic electromagnetic treatment devices in a fitment, comprising the following steps: a) providing a ...
|
|
|
Heart Surgery 
