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| Cardiac assist system and method thereof |
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| Automated system for the radiation treatment of a desired area within the body of a patient |
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System for administering a combination of therapies to a body lumen
| Details |
Inventors: Shaw, William J.; Barry, James; Goll, Paul J.; Palasis, Maria;
Assignee: SciMed Life Systems (Maple Grove, MN)
Primary Examiner: Hindenburg; Max F.
Assistant Examiner: Veniaminov; Nikita R.
Attorney, Agent or Firm: Jones Day;;
The invention provides a system which comprises a medical device that delivers a combination of therapies. These therapies include the administration of radiation, biologically active materials, cryotherapy, and thermotherapy. The present invention is also directed to a method of treating body lumen surfaces using the system of the invention. A system is provided for delivering a biologically active material to a surface of a body lumen being exposed to a radioactive source. In one aspect, the system comprises an implantable medical device which has two opposing ends, each having a surface, and a middle portion. The two opposing ends comprise a biologically active material and the middle portion of the medical device is substantially free of any biologically active material. In another aspect, the system delivers a genetic material to a surface of a body lumen which is exposed to a radioactive source. Another system is provided for treating a surface of a body lumen in which the system comprises an implantable medical device which comprises a biologically active material and a device for applying a therapy source to the parts of the body lumen surface that are in contact with the opposing ends of the medical device. The therapy source may be a cryotherapy source or a thermotherapy source. |
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DETAILED DESCRIPTION The present invention is aimed at using an implantable medical device to effect a desired treatment, which is often, but not necessarily, the prevention of restenosis.
Specifically, the invention is aimed at reducing the incidence of restenosis by exposing a potential restenosis site to treatment by, e.
g.
radiation, biologically active materials, genetic materials, cryotherapy and thermotherapy.
The system of the present invention was designed to provide a therapy which may include any of the above treatments in combination.
In one embodiment of the present invention, a system is provided for delivering a biologically active material to a surface of a body lumen exposed to a radioactive source.
The radioactive source can be, but need not be, incorporated into the medical device.
This system comprises an implantable medical device which has two opposing ends, each having a surface, and a middle portion and a surface.
At least one biologically active material is applied to at least one end of the device.
An end is a portion of the device at the terminus of the device that is no more than about 25% of the total length of the device.
The middle portion of the medical device is substantially free of any biologically active material.
In another embodiment, a system comprises an implantable medical device comprises at least one biologically active material coated onto the surface of the device.
Furthermore, in yet another embodiment, the present invention provides a system for delivering a biologically active material to a surface of a body lumen exposed to a radioactive source.
The system comprises an implantable medical device having two opposing ends and a middle portion and a surface.
At least one biologically active material is applied to the ends of the medical device.
The radioactive source is applied to the middle portion of the medical device and the end portions of the medical device are substantially free of direct exposure to the radiation source.
In a specific embodiment, the biologically active material is applied to the middle portion of the medical device
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