Home | Links | Contact Us | More About Intellectual Property | Bookmark
Search patents:
Home Heart Surgery Therapeutic-treatment-for-congestive-heart-failure

 Multi-lumen cannula
The cannula according to the invention overcomes the problems of the prior art by providing a multi-...


 Brachytherapy seed deployment system
One aspect of the present invention is to enable brachytherapy needles to be preloaded with ...


 Reciprocating pump and linear motor arrangement
In accordance with one aspect of the invention, a surgically implantable reciprocating pump for ...


 Implantable device monitoring arrangement and method
We claim: 1. A monitoring arrangement for monitoring and controlling a device implantable in a ...


 Articulated arm for holding surgical instruments
The present invention provides an articulated arm for holding surgical instruments which comprises ...


 Active magnetic bearing system for blood pump
In accordance with the present invention, a rotary blood pump is provided. The pump comprises a ...


 Apparatus and method for folding and stacking napkins
It is an object of the present invention to provide a method and apparatus for folding and stacking ...


 Method and apparatus for calendering and coating/filling sutures
Accordingly, a method and apparatus for treating a multifilament surgical suture are provided ...


 Rotatable cuff assembly for a heart valve prosthesis
The invention provides a heart valve prosthesis in which the sewing cuff is rotatably mounted to ...


 Device and method for isolating a surface of a beating heart during surgery
The present invention provides a device and method for isolating a heart surface, particularly, the ...


 Therapeutic treatment for congestive heart failure

Details
Inventors: Gavras, Haralambos;
Assignee: Trustees of Boston University (Boston, MA)
Primary Examiner: Brown; J. R.
Assistant Examiner: Moezie; F. T.
Attorney, Agent or Firm: Prashker; David

A novel therapeutic method for treating human and animal subjects afflicted with congestive heart failure is provided by administering effective dosages of a selective antagonist for arginine vasopressin to the subject. The antagonist is an effective and potent inhibitor for vasopressin and is a therapeutic agent selected from the class consisting of analogues of previously prepared compositions synthesized in a conventionally known manner. The administration of such selective antagonist as a therapeutic agent results in a demonstrated beneficial change in approximately thirty percent of tested individuals.

DETAILED DESCRIPTION OF THE FIGURES The present invention may be more fully and easily understood when taken in conjunction with the accompanying drawing, in which: FIG.
1 is a graph illustrating the baseline concentration of plasma arginine vasopressin in each of ten different human patients under test; and FIG.
2 is a graph illustrating the change in systemic vascular resistance following administration of a selective antagonist.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention is a therapeutic method for treating human and/or animal subjects afflicted with the pathological condition known as congestive heart failure.
The method utilizes a potent and selective class of antagonists for arginine-vasopressin (hereinafter "AVP") which have been previously prepared and evaluated as effective antagonists of vasopressin.
There are ten analogues in the class as a whole each of which conforms to the following general structure: ##STR1## Specifically, the 10 analogues comprising the class are as follows: 1.
[1-(.
beta.
-mercapto-.
beta.
,.
beta.
-cyclopentamethylenepropionic acid),2-(O-methyl)-D-tyrosine,4-valine,8-D-arginine]vasopressin; 2.
[1-(.
beta.
-mercapto-.
beta.
,.
beta.
-cyclopentamethylenepropionic acid, 2-(O-ethyl)-D-tyrosine,4-valine,8-D-arginine]vasopressin; 3.
[1-(.
beta.
-mercapto-.
beta.
,.
beta.
-cyclopentamethylenepropionic acid),2-(O-isopropyl)-D-tyrosine,4-valine,8-D-arginine]vasopressin; 4.
[1-(.
beta.
-mercapto-.
beta.
,.
beta.
-cyclopentamethylenepropionic acid),2-(O-n-propyl)-D-tyrosine,4-valine,8-D-arginine]vasopressin; 5.
[1-(.
beta.
-mercapto-.
beta.
,.
beta.
-cyclopentamethylenepropionic acid),2-(O-methyl)-D-tyrosine,4-valine]arginine-vasopressin; 6.
[1-(.
beta.
-mercapto-.
beta.
,.
beta.
-cyclopentamethylenepropionic acid),2-(O-ethyl)-D-tyrosine,4-valine]arginine-vasopressin; 7.
[1-(.
beta.
-mercapto-.
beta.
,.
beta.
-cyclopentamethylenepropionic acid),2-(O-isopropyl)-D-tyrosine,4-valine]arginine-vasopressin; 8.
[1,(.
beta.
-mercapto-.
beta.
,.
beta.
-cyclopentamethylenepropionic acid),2-(O-n-propyl)-D-Tyrosine,4-valine]arginine-vasopressin; 9



Related patents
  Pyrrolidine compound and pharmaceutical use
What is claimed is: 1. A pyrrolidine compound having the formula or a pharmacologically acceptable salt thereof: ##STR87## in which X is hydrogen, a halogen or a lower ...
  Retrograde coronary sinus catheter
OF A PREFERRED EMBODIMENT Now referring to the drawing, a coronary sinus catheter assembly of the invention is indicated in its entirety by the reference numeral 10. T...
  Cardioplegia catheter system
The present invention provides methods, systems and devices for inducing cardioplegic arrest and for isolating the coronary arteries from the systemic circulation to ...
  Emulsions of perfluoro compounds as solvents for nitric oxide (NO)
This invention discloses an emulsion comprising a perfluoro compound and nitric oxide and uses thereof. Methods of preparing such a nitric oxide source suitable for in ...
  Extracorporeal circulation apparatus and method
We claim: 1. A method of reducing inflammatory response resulting from contact of blood with surfaces in an extracorporeal fluid, comprising: (a) providing an ...
  ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST*** *** NO IMAGES AVAILABLE***
Description:...
  Actuator for heart pump
Having described my invention, I claim: 1. In a heart pump having a housing, inlet and outlet passageways in said housing, a diaphragm means for reciprocating said ...
  Involute cam actuator with piston drive
We claim: 1. A mechanism for producing a linear relationship between angular movement of a shaft and axial movement of a piston comprising: a piston operating along an ...
  Sexual aid
In view of the foregoing disadvantages inherent in the known types of sex devices now present in the prior art, the present invention provides an improved sexual aid. As ...
  Percutaneous transseptal left atrial cannulation system
The cannulation method of Bernstein is complex. The insertion and removal of the guide wire, the needle, and obturator within the catheter risks potential system ...

0.004

Archive: All patents - Links

Copyright (c)2006 Eipa-patents.org - All rights reserved