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Method of living organism multimodal functional mapping
| Details |
Inventors: Godik, Eduard E.;
Assignee: Dynamics Imaging, Inc. (Mahwah, NJ)
Primary Examiner: Casler; Brian
Assistant Examiner:
Attorney, Agent or Firm: Erlich; Jacob N., Cohen; Jerry
A method of diagnosis of a living organism by providing at least one functional map of the living organism, the method having the steps of determining at least two physical parameters characterizing the physiological state of the living organism, recording spatial-temporal distributions of the at least two physical parameters, acquiring and processing information about the spatial-temporal distributions of the at least two physical parameters, and utilizing the information about the spatial-temporal distributions of the at least two physical parameters to generate the at least one functional map of the living organism. Further steps include using one of the at least two physical parameters as a reference for selecting another of the physical parameters, substantially simultaneously recording the spatial-temporal distributions of the at least two physical parameters or recording the spatial-temporal distributions of the at least two physical parameters at a preselected time interval apart from one another. |
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DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT The method of the present invention involves recording the spatial-temporal distributions of one or several parameters (dynamic maps) of physical fields and radiations, providing information about physiological processes at (or near) the surface of the diagnosed living organism.
Either simultaneously or after some time interval, the spatial-temporal distributions of one or several other parameters of the physical fields and radiations also at (or near) the same living organism's surface are measured.
The recorded parameters or measurements are the living organism's own physical fields' tensions and/or radiation intensities, as well as external fields' tensions and/or external radiations intensities changed as a result of the presence of the living organism investigated.
Alternatively, the physical characteristics of another living organism's surface can be measured and combined with the above measurements.
The first or higher order time and space derivatives of the physical parameters are often also recorded.
These spatial-temporal distributions of the physical parameters are called dynamic or functional maps.
The physical parameters depicted by the dynamic map by itself and, especially, the interconnection characteristics of the spatial-temporal dynamics parameters contain information on the functioning of theliving organism's physiological systems.
In order to determine the functional status of the living organism, the characteristics of the interconnection between several physical parameters are analyzed.
In the simplest case, only two parameters are considered.
Of special importance while constructing the aforementioned functional or dynamic maps, is the analysis of the parameters' temporal behavior.
Such analysis is performed by the comparison of the information elements of the parameters' dynamic maps, representing temporal behavior of the parameter at some spatial point or that averaged over some spatial area of the dynamic map.
Sometimes, it is more convenient to use, as the information element of the parameter's dynamic map, a temporal regularity in the behavior of the histogram of the parameter amplitude at some fixed value of the latter
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Image Analysis 
