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Organism-specimen-morphological-change-detecting-apparatus-and-organism-specimen-morphological-change-detecting-method

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Organism-specimen morphological-change detecting apparatus, and organism-specimen morphological-change detecting method

Details

Inventors: Yahiro, Kanji;
Assignee: Matsushita Electric Industrial Co., Ltd. (Osaka, JP)
Primary Examiner: Patel; Jayanti K.
Assistant Examiner: Tabatabai; Abolfazl
Attorney, Agent or Firm: Wenderoth, Lind & Ponack, L.L.P.

The present invention relates to an apparatus of optically detecting morphological change of an organism specimen such as an animal/plant cell. In a candidate compound screening for detecting a candidate compound among compounds, a camera of a microscope apparatus takes images of an organism specimen in a plate before and after a dosage of each compound-containing solution to the organism specimen by a dispensing head. An image processor processes the taken microscopic images and provides numerical data as a quantitative indicator of a state of the organism specimen. The screening apparatus judges whether each compound solved in each solution is the candidate compound by comparing numerical data before and after the dosage of the solution with each other.

DETAILED DESCRIPTION The present invention addresses the problems discussed above.
An organism-specimen morphological-change detecting apparatus in accordance with the present invention comprises a solution administering mechanism for administering a compound-containing solution to an organism specimen, an image taking unit for taking a microscopic image of the organism specimen, and a quantitative evaluation unit for processing the image taken by the image taking unit and outputting numeric data for indicating a state of the organism specimen.
An organism-specimen morphological-change detecting method in accordance with the present invention comprises the following steps: (a) taking a microscopic images of an organism specimen before a dosage of a compound containing solution; (b) processing the images taken in step (a), deriving numeric data before the dosage for indicating the state of the organism specimen, and storing the derived numeric data; (c) taking a microscopic images of the organism specimen at a predetermined interval after the dosage of the solution at the same scaling factor as in step (a); and (d) processing the images taken in step (c), deriving numeric data after the dosage for indicating the state of the organism specimen, and storing the derived numeric data.

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