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Device and apparatus for conducting an assay
| Details |
Inventors: Andrewes, David; Attridge, John Worthington; Griffiths, David; Vessey, John Phillip; Odell, John Anthony; Fernando, Felix; Stevenson, Anthony; Gresswell, Mark; Curtis, John; Percival, David Alan;
Assignee: Provalis Diagnostics LTD (Deeside, GB)
Primary Examiner: Chin; Christopher L.
Assistant Examiner: Padmanabhan; Kartic
Attorney, Agent or Firm: Hogan & Hartson LLP
A apparatus for assaying glycated proteins and other analytes in biological samples such as blood, in which a sample is presented to the apparatus, includes an inlet port between moveable between first and second inlets, such that the inlet can be brought into liquid communication with each inlet in turn. The inlet port accommodates a filter or binder. The apparatus also includes a microprocessor operable via a key pad, at least one light emitter and at least one light detector, a display and driver, and an A to D converter, and is operatively connected to a power source. |
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DETAILED DESCRIPTION To that end, therefore, we have in a first aspect of the invention devised an apparatus which allows rapid, easy sample treatment combined with compatibility with a one-step device such as that exemplified by HELISAL.
RTM.
ONE-STEP.
According to a first aspect the present invention there is provided an apparatus, for use in an assay in which a sample is presented to an instrument, comprising a first inlet, a second inlet, and an inlet port, said inlet port being moveable relative to each of said first and second inlets such that the port can be brought into liquid communication with each inlet in turn as required, wherein said inlet port accommodates a filter means or a binder retaining means.
In one embodiment the apparatus is adapted to be used in an assay system where some form of particulate is added to a sample which may contain a detectable analyte, where the particulate is capable of binding the analyte.
Thus when the sample plus particulate is added to the inlet port, the particulate, with bound analyte, is retained by the filter.
The filter can of course be constructed of any suitable material.
Suitably, it will be made of material which is inert in terms of the analyte etc.
Also the "mesh" of the filter must be such that it is capable of retaining particulates as used in the separation step.
The inlet port can then be moved into alignment with the second inlet means and one or more reagents capable of interfering with the binding of the analyte to the particulate can be added to the inlet port.
The analyte (if present) will then pass through the filter in solution, leaving the particulates behind.
Thus, taking the example of glycated Hb, a sample of blood is treated to lyse the blood cells and is then admixed with particulates, eg agarose or cellulose, to which is bound phenyl boronate.
The treated sample is then introduced into the apparatus via the inlet port, which will have been moved into liquid communication with the first inlet.
The liquid part of the sample, which contains non-glycated Hb, will pass through into the body of the apparatus, while the particulates, to which will be bound any glycated Hb, will be retained by the filter means associated with the inlet port
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LCD 
