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Apheresis apparatus for separating an intermediate density component from whole blood
| Details |
Inventors: Latham, Jr., Allen; Jorgensen, Glen E.; Sibinga, Theodoor H. S.; Plante, Joseph R.; Knapp, Tracey E.;
Assignee: Haemonetics Corporation (Braintree, MA)
Primary Examiner: Kim; John
Assistant Examiner:
Attorney, Agent or Firm: Cesari and McKenna
An apheresis apparatus for increasing the purity and yield of platelets separated from donated whole blood by centrifugation incorporates a centrifuge for separating whole blood into lower, intermediate, and higher density components. The centrifuge has inlet and outlet ports in selective fluid communication with a container for receiving lower density blood component from the outlet port. A pump is coupled to the container and the inlet port for recirculating lower density blood component from the first container through the inlet port into the centrifuge at a first, substantially constant, rate so as to widen the region of the centrifuge occupied by the intermediate density component without causing the intermediate density component to exit the centrifuge, and subsequently at a second rate, so as to displace intermediate density component from the centrifuge. |
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DETAILED DESCRIPTION The present invention provides a pheresis apparatus and method for increasing blood component yield from donated whole blood in a centrifugation fractionation volume.
In accordance with the invention, whole blood is diluted by recirculating lower density fluid, preferably plasma, at a first flow rate, to mix with further withdrawn whole blood prior to entering the centrifuge.
The diluted whole blood enters the fractionation or separation volume through an inlet port and is separated by centrifugation in the volume into a lower density components and higher density components.
The higher density components are mainly red blood cells, white blood cells and platelets.
The lower density component is mainly plasma.
During separation, lower density component is displaced from the volume through an outlet port to a first container.
The blood pump is stopped and the collected lower density component is then returned to the separation volume through the inlet port at a second flow rate.
The second flow rate is greater than the first flow through a "buffy coat" (made up of white blood cells and platelets), thereby diluting and widening the "buffy coat".
The widened "buffy coat" improves the separation between white blood cells and platelets by allowing the denser white blood cells to sediment from the lighter platelets more completely to the outer layers of the buffy coat.
In this manner, the separation of the higher density components remaining in the volume is improved.
The improved separation between the white blood cells and platelets reduces the amount of white blood cell contamination when the platelets are finally collected.
The lower density component is then recirculated again through the volume at a third flow rate and component with density between lower density component and higher density components (the platelets) is displaced out of the volume while the lower density component is recirculating through the volume at the third flow rate.
The third flow rate is at a rate greater than the second flow rate
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Liquid Purification 
