DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The following description will enable a person skilled in the art to which this invention pertains to make and use the invention, and sets forth the best modes contemplated by the inventors of carrying out their invention.
The present invention provides materials and methods useful in disinfecting biological fluids, particularly blood, blood fractions, blood plasma and plasma derived products, as well as fluids associated with the production of recombinant and transgenic products, e.
g.
, cell culture supernatants, milk, etc.
Materials useful in the present invention include insoluble matrix materials complexed with a disinfecting agent such as a halogen, hydrogen peroxide, or other oxidizing or derivatizing agent.
Preferred materials include iodinated chromatographic matrix materials.
Particularly preferred matrix materials are iodinated ion exchange resins.
As used herein, and unless stated otherwise, the term "iodine" (or "iodinated") includes iodine in any of its various forms, e.
g.
, diatomic iodine (I.
sub.
2), ionic iodine (e.
g.
, I.
sup.
- or iodide), iodine as free radical, molecular ionic iodine (e.
g.
, triiodide anion (I.
sub.
3.
sup.
-)), and related species derived from I.
sub.
2.
the term "blood products" includes blood fractions such as plasma and blood derived products such as clotting factors, red cell platelets, white cells, immunoglobulins and the like; the term "biological fluid" refers to a protein-containing fluid of human or non-human origin, whether solution, mixture or suspension, and includes blood, blood fractions, milk, urine, semen, saliva, cell culture supernatants, and other fluids, of either natural or synthetic origin, that contain biologically significant components, particularly proteins; the term "matrix material" refers to any insoluble, durable material conventionally used as a carrier or substrate material in a chemical separations process and capable of complexing, adsorbing, or otherwise binding iodine; and the term "disinfect" means to inactivate, kill, or otherwise render non-pathogenic a pathogenic contaminant found in blood such as a virus, bacterium, microorganism, or other pathogenic species such as a prion, prion-related protein ("PRP"), etc
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Liquid Purification 
