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 Separating agent

Details
Inventors: Okamoto, Yoshio; Hatada, Koichi; Shibata, Tohru; Okamoto, Ichiro; Nakamura, Hiroyuki;
Assignee: Daicel Chemical Industries, Ltd. (Sakai, JP)
Primary Examiner: Therkorn; Ernest G.
Assistant Examiner:
Attorney, Agent or Firm: Flynn, Thiel, Boutell & Tanis

A mixture of chemical substances such as optical isomers, geometrical isomers and polymers having different molecular weight ranges is separated to each ingredient by use of a cellulose derivative having an aromatic ring in the chromatographic method.

DETAILED DESCRIPTION The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 1.
A separating agent which comprises a cellulose derivative selected from the group consisting of cellulose tribenzoate and cellulose tribenzoate ring-substituted with alkyl, alkenyl, alkynyl, nitro, halogen, amino, alkyl-substituted amino, cyano, hydroxyl, alkoxy, acyl, thiol, sulfonyl, carboxyl or alkoxy carbonyl, said cellulose derivative being supported on a porous carrier having a particle size of from 1 micron to 10 millimeters and a pore size of from 10 Angstrom units to 100 microns.
2.
A separating agent as claimed in claim 1 in which said cellulose derivative is cellulose tribenzoate.
3.
A separating agent as claimed in claim 1, wherein the amount of said cellulose derivative supported on said carrier is from 1-100 wt.
% based on the weight of the carrier.
4.
A separating agent as claimed in claim 1, wherein the ratio of pore size to particle size of said carrier is not larger than 0.
1:1.
5.
A separating agent as claimed in claim 1, wherein said carrier is an inorganic substance selected from the group consisting of silica, alumina, magnesia, titanium oxide, glass, silicate and kaolin.
6.
A separating agent as claimed in claim 1, wherein said carrier is an organic substance selected from the group consisting of polystyrene, polyacrylamide and polyacrylate.
7.
A separating agent as claimed in claim 1 in which said cellulose derivative is coated on said carrier and has been prepared by mixing said carrier with a solution of said cellulose derivative in a solvent therefor, and then removing said solvent.
8.
A separating agent as claimed in claim 5, in which said carrier is an inorganic substance.
9.
A separating agent as claimed in claim 8, in which said inorganic substance is silica gel.
10.
A chromatographic isomer separating agent comprising a derivative of cellulose selected from the group consisting of cellulose tribenzoate and cellulose tribenzoate ring-substituted with alkyl, alkenyl, alkynyl, nitro, halogen, amino, alkyl-substituted amino, cyano, hydroxyl, alkoxy, acyl, thiol, sulfonyl, carboxyl or alkoxy carbonyl having a number average degree of polymerization in the range of 5-5000 supported on a solid carrier having a particle size of from 1 micron to 10 millimeters



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