Separation agent comprising aliphatic or aromatic ester of polysaccharide

DETAILED DESCRIPTION The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 1.
A chromatographic separating agent comprising xylan dibenzoate supported on a porous carrier having a particle size range of from 1 micron to 10 millimeter and a pore size of from 10 Angstroms to 100 microns, the amount of xylan dibenzoate to be supported is 1 to 100 wt.
% based on the carrier.




Description:
The invention relates to a separation agent which essentially comprises an aliphatic ester of a polysaccharide, excluding cellulose acetate.
It is useful for separation of various chemical substances, especially optical resolution of optical isomers.
The resolving agent of the present invention can be used for separation of all sorts of chemical substances, particularly for optical resolution of them.
It has been well known that optical isomers of a chemical compound have effects different from each other in vivo generally.
Therefore, it is important to obtain optically pure compounds for the purposes of improving medicinal effects per unit dose of them and removing adverse reactions thereof and damage from them in medical, agricultural and biochemical fields.
A mixture of optical isomers has been optically resolved by preferential crystallization or diastereomer process.
However, varieties of compounds capable of being optically resolved by these processes are limited and these processes require a long time and a much labor.
Under these circumstances, development of a technique of conducting the optical resolution by an easy chromatographic process has eagerly been demanded.
Chromatographic optical resolution has been investigated from old times.
However, resolving agents developed heretofore have problems that they have only an unsatisfactory resolution efficiency, compounds to be resolved should have a specific functional group and their stability is only poor.
Thus, it has been difficult to optically resolve all sorts of compounds with satisfactory results