 4-[(Carboxyl- and sulfamyl-substituted alkyl)-amino] benzoic acids and analogs |
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| Automatic sludge extraction and washing device for use in a water treatment settling apparatus |
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4-Styryl-hexahydro-4-indolinols
| Details |
Inventors: Berthold, Richard;
Assignee: Sandoz Ltd. (Basel, CH)
Primary Examiner: Moyer; Donald B.
Assistant Examiner:
Attorney, Agent or Firm: Sharkin; Gerald D., Vila; Richard E., Weinfeldt; Frederick H.
The present invention provides compounds of formula I, ##STR1## wherein R.sub.1 and R.sub.2 are, independently, hydrogen, fluorine, chlorine, trifuoromethyl, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms, and R.sub.3 is hydrogen, or alkoxy of 1 to 4 carbon atoms, with the proviso that when R.sub.3 is alkoxy then at least one of R.sub.1 and R.sub.2 is alkoxy, or R.sub.1 and R.sub.2 are bound to adjacent ring carbon atoms and are together --(CH.sub.2).sub.m --, wherein m is 3 or 4, --CH.dbd.CH--CH.dbd.CH--, or --O--CH.sub.2 --X--, wherein X is --O-- or --CH.sub.2 --, and R.sub.3 is hydrogen, fluorine, chlorine, trifluoromethyl, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms, Useful as hypolipidemic agents and anti-arrhythmics. |
|
DETAILED DESCRIPTION I claim: 1.
A compound of formula I, ##STR7## wherein R.
sub.
1 and R.
sub.
2 are, independently, hydrogen, fluorine, chlorine, trifluoromethyl, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms, and R.
sub.
3 is hydrogen, or alkoxy of 1 to 4 carbon atoms, with the proviso that when R.
sub.
3 is alkoxy then at least one of R.
sub.
1 and R.
sub.
2 is alkoxy, or R.
sub.
1 and R.
sub.
2 are bound to adjacent ring carbon atoms and are together --(CH.
sub.
2).
sub.
m --, wherein m is 3 or 4, --CH.
dbd.
CH--CH.
dbd.
CH--, or --O--CH.
sub.
2 --X--, wherein X is --O-- or --CH.
sub.
2 --, and R.
sub.
3 is hydrogen, fluorine, chlorine, trifluoromethyl, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms, or a pharmaceutically acceptable acid addition salt thereof.
2.
A compound of claim 1 in which any alkyl or alkoxy radical has 1 or 2 carbon atoms.
3.
A compound of claim 1 in which any alkyl or alkoxy radical has 1 carbon atom.
4.
A compound of claim 1 in which R.
sub.
1 and R.
sub.
2 are identical when they are fluorine, chlorine, or alkyl.
5.
A compound of claim 1 in which alkoxy groups are identical when there are two or three such groups present.
6.
A compound of claim 1 in which R.
sub.
1 and R.
sub.
2 when defined together are other than O--CH.
sub.
2 --X--.
7.
A compound of claim 1 in which R.
sub.
1 and R.
sub.
2 are chosen from the group of hydrogen, methyl or methoxy.
8.
A compound of claim 1 in which R.
sub.
3 is hydrogen or methoxy.
9.
A compound of claim 1 in free base form.
10.
A compound of claim 1 in the form of a pharmaceutically acceptable acid addition salt.
11.
The compound of claim 1 which is (3aRS, 4RS, 7aRS)-4-(3,4-dimethoxy-(Z)-styryl)-hexahydro-4-indolinol.
12.
The compound of claim 1 which is the hydrogen maleate salt of (3aRS, 4Rs, 7aRS)-4-(3,4-dimethoxy-(Z)-styryl)-hexahyro-4-indolinol.
13.
The compound of claim 1 wherein R.
sub.
1, R.
sub.
2 and R.
sub.
3 are respectively 4--CH.
sub.
3, H and H.
14.
The compound of claim 1, wherein R.
sub.
1, R.
sub.
2 and R.
sub.
3 are respectively 4--CH
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Molecular Biology 
