Amide derivatives of acids, an antibiotic produced by Polyangium cellulosum var. fulvum

DETAILED DESCRIPTION The present invention relates to novel cyclic and acyclic amides obtained by structurally modifying substance known as acid S, a potent antibiotic isolated from Polyangium cellulosum var.
fulvum (ATCC No.
25532).
Specifically, the present invention relates to amide derivatives of acid S having the formula I or II: ##STR1## wherein X in formula I is alkyl, aralkyl or cycloalkyl, wherein alkyl is a 1 to 7 carbon lower alkyl and aryl is phenyl or naphthyl; and n in formula II is any number from 3 to 8.
Preferably, X in formula I is 1 to 4 carbon lower alkyl or benzyl; and n in formula II is 4 or 5.
R in formula I and II is the neutral part of the acid S molecule and has the empirical formula C.
sub.
27 H.
sub.
41 O.
sub.
4.
The acid S molecule has the formula R-CO.
sub.
2 H (C.
sub.
28 H.
sub.
42 O.
sub.
6).
The cyclic and acyclic amide derivatives of acid S formed according to the process of this invention may be acetylated to determine the number of secondary hydroxyl groups in each of the structural modifications.
By means of this acetylation reaction, it was found that, in each case, the corresponding diacetate is formed indicating the presence of two hydroxyl groups.