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Carbonylation of olefins and acetylenes
| Details |
Inventors: Thompson, David Thomas; Jackson, Reginald;
Assignee: Imperial Chemical Industries Limited (London, EN)
Primary Examiner: Weinberger; Lorraine A.
Assistant Examiner: Killos; P. J.
Attorney, Agent or Firm: Cushman, Darby & Cushman
Olefins and acetylenes are carbonylated to a carboxylic acid or ester using a homogenous catalyst system comprising palladium together with iron or a metal of Groups IVA, VA or IIIB, the catalyst being either a polynuclear complex incorporating both metals, or a mixture of a soluble palladium salt and metal halide. Starting with cyclic di-olefins, such as cyclo-octadiene, the product cycloalkenyl carboxylic acid or ester may be cleaved to give acyclic dicarboxylic acids, such as azelaic acid. |
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DETAILED DESCRIPTION What we claim is: 1.
A process for the preparation of acyclic dicarboxylic acids in which a.
a cyclic olefin selected from the group consisting of cycloalkadienes and alkenylcycloalkenes is carbonylated to a cycloalkenyl carboxylic acid or ester by reaction with carbon monoxide and a hydroxylic compound selected from the group consisting of water, alcohols, and phenols in the presence of a homogeneous catalyst composition including palladium and aluminum, the catalyst composition being a polynuclear organic complex incorporating palladium in combination with aluminum or being a mixture of a soluble palladium compound with a chloride of the further metal, b.
the reaction mixture resulting from the above carbonylation reaction is heated to an elevated temperature under alkaline conditions to induce cleavage of the cycloalkenyl ring, and c.
the acyclic dicarboxylic acid is isolated from the reaction mixture.
2.
A process for the preparation of acyclic dicarboxylic acids in which a.
a cyclic olefin selected from the group consisting of cycloalkadienes and alkenylcycloalkenes is carbonylated to a cycloalkenyl carboxylic acid or ester by reaction with carbon monoxide and a hydroxylic compound selected from the group consisting of water, alcohols and phenols in the presence of a homogeneous catalyst composition consisting essentially of a mixture of a soluble palladium complex, a halide of aluminum and a substituted phosphine ligand which may constitute part of said palladium complex, b.
the reaction mixture resulting from the above carbonylation reaction is heated to an elevated temperature under alkaline conditions without intermediate purification to induce cleavage of the cycloalkenyl ring, and c.
the acyclic dicarboxylic acid is isolated from the reaction mixture.
3.
A process as claimed in claim 2 in which the cyclic olefin is cyclo-octa-1,5-diene and the dicarboxylic acid is azelaic acid.
4.
In a process for the preparation of carboxylic acids or esters in which an olefinically unsaturated compound is carbonylated by reaction with carbon monoxide and a hydroxylic compound selected from the group consisting of water, alcohols and phenols, the improvement wherein the carbonylation is carried out in the presence of a homogeneous catalyst composition consisting essentially of a mixture of a soluble palladium complex, a halide of aluminum and a substituted phosphine ligand, which optionally constitutes part of said palladium complex
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Molecular Biology 
