Certain fluorine substituted PGI.sub.2 compounds

DETAILED DESCRIPTION What is claimed is: 1.
A compound of the formulae: ##STR22## wherein Y, T, W and X may each be H or F; provided that at least one of Y, T, W and X is F; V may be hydrogen, hydroxy, acyloxy, lower alkoxy, hydroxy lower alkyl, or oxo; Z may be --Z.
sub.
1 --E wherein: Z.
sub.
1 is (CH.
sub.
2).
sub.
g --CH.
sub.
2 --CH.
sub.
2 --, or --(CH.
sub.
2).
sub.
g --O--CH.
sub.
2 --, or --(CH.
sub.
2).
sub.
g --CH.
sub.
2 --CF.
sub.
2 --, or trans-(CH.
sub.
2).
sub.
g --CH.
dbd.
CH--; wherein g is 0, 1 or 2; and E is --COOX.
sub.
1, wherein X.
sub.
1 is hydrogen, alkyl, cycloalkyl, aralkyl, phenyl, phenyl substituted with chloro or alkyl, an alkali metal or an ammonium cation; or --CH.
sub.
2 OH; or ##STR23## --CH.
sub.
2 NL.
sub.
2 L.
sub.
3, wherein L.
sub.
2 or L.
sub.
3 are hydrogen, alkyl or --COOX.
sub.
1 wherein X.
sub.
1 is as defined above; --COL.
sub.
4, wherein L.
sub.
4 is, (a) amino of the formula --NR.
sub.
21 R.
sub.
22, wherein R.
sub.
21 and R.
sub.
22 are hydrogen, alkyl of 1 to 12 carbon atoms inclusive, aralkyl of 7 to 12 carbon atoms inclusive, phenyl, phenyl substituted with 1, 2 or 3 chloro or alkyl substituents of 1 to 3 carbon atoms inclusive, or phenyl substituted with hydroxy carbonyl or alkoxy carbonyl of 1 to 4 carbon atoms inclusive; or (b) carbonylamino of the formula, --NR.
sub.
23 COR.
sub.
21, wherein R.
sub.
23 is hydrogen or alkyl of 1 to 4 carbon atoms and R.
sub.
21 is as defined above; or (c) sulfonylamino of the formula --NR.
sub.
23 SO.
sub.
2 R.
sub.
21, wherein R.
sub.
21 and R.
sub.
23 are as defined above; or --COOL.
sub.
5, wherein L.
sub.
5 is p-substituted phenyl selected from the group consisting of: ##STR24## wherein R.
sub.
24 is methyl, phenyl, acetamidophenyl, benzamidophenyl, or --NH.
sub.
2 ; R.
sub.
25 is methyl, phenyl, --NH.
sub.
2, or methoxy; and R.
sub.
26 is hydrogen or acetamido; and L is ##STR25## wherein n is 1 or 2; and A is trans--CH.
dbd.
CH--, or cis--CH.
dbd.
CH--, or --CH.
sub.
2 --CH.
sub.
2 --, or --C.
tbd.
C--, or trans--CH.
dbd.
C(Halogen)--; and ##STR26## wherein R.
sub.
3 and R.
sub.
4 may be H, OH, alkoxy, acyloxy, or fluoro with the proviso that one of R