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Chloramphenicol derivatives, antigens and antibodies
| Details |
Inventors: Hu, Mae W.; Singh, Prithipal;
Assignee: Syntex (U.S.A.) Company (Palo Alto, CA)
Primary Examiner: Kight; John
Assistant Examiner: Nutter; Nathan M.
Attorney, Agent or Firm: Leitereg; Theodore J.
Chloramphenicol derivatives are provided for use in preparing antigen conjugates for the production of antibodies specific for chloramphenicol. Specifically, the aryl group is derivatized with a side chain functionalized to provide for a carbonyl functionality to react with amino groups of a poly(amino acid). The conjugate is then injected into a vertebrate for production of antisera which are isolated in conventional ways and find particular use in competitive protein binding assays. |
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DETAILED DESCRIPTION What is claimed is: 1.
A compound of the formula: ##STR6## wherein: Q is chalcogen of atomic number 8 to 16 or nitrogen; p is 0 or 1; R is a linking group of at least 1 carbon atom and not more than 12 atoms other than hydrogen; Z is hydrogen, hydroxy, alkoxy of from 1 to 6 carbon atoms, a group forming an activated ester capable of amide formation in an aqueous medium, or a poly(amino acid) which is antigenic or an enzyme; m is 0 or 1 when Z is a poly(amino acid) and is otherwise 1; and n is 1 when Z is other than a poly(amino acid) and is otherwise a number between one and the molecular weight of Z divided by 1000.
2.
The compound of claim 1 wherein R is a polymethylene of from 1 to 5 carbon atoms.
3.
The compound of claim 2 wherein Q is sulfur, p is 1, R is one carbon atom, and m is 1.
4.
A compound of the formula: ##STR7## wherein: Q is chalcogen of atomic number 8 to 16 or nitrogen, p is 0 or 1; R is a saturated aliphatic linking group of from 1 to 6 carbon atoms; Y.
sup.
1 is a poly(amino acid); m is 0 or 1; and n.
sup.
1 is a number divided between one and the molecular weight of Y.
sup.
1 divided by 2000.
5.
The compound of claim 4 wherein Q is sulfur, p is 1, R is one carbon atom, and m is 1.
6.
The compound of claim 4 wherein Y.
sup.
1 is an antigen.
7.
The compound of claim 4 wherein Y.
sup.
1 is serum albumin.
8.
The compound of claim 4 wherein Y.
sup.
1 is gamma globulin.
9.
Antibodies prepared in response to the compound of claim 6.
10.
The compound of claim 4 wherein Y.
sup.
1 is an enzyme.
11.
The compound of claim 10 wherein said enzyme is glucose-6-phosphate dehydrogenase.
12.
A compound of the formula: ##STR8## wherein: Q is chalcogen of atomic number 8 to 16 or nitrogen; p is 0 or 1; R is a linking group of from 1 to 12 atoms other than hydrogen; Y.
sup.
2 is an enzyme substituted at other than the active site, and having at least 30 percent of its original activity prior to conjugation; m is 0 or 1; and n.
sup.
2 is 1 to 30.
13.
A compound of the formula: ##STR9## wherein: Q is chalcogen of atomic number 8 to 16 or nitrogen; p is 0 or 1; R is a saturated aliphatic linking group of from 1 to 8 carbon atoms; Y
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Molecular Biology 
