Home | Links | Contact Us | More About Intellectual Property | Bookmark

Search patents:

Home

Molecular Biology

DNA-encoding-histidyl-tRNA-synthetase-variant-from-Streptococcus-pneumoniae

Method of and apparatus for filtering

The present invention relates to an improved filtration method and apparatus, and more particularly ...

Subsurface waste disposal system

An artificial perched bed of selected granular soil media including a plurality of layers is ...

Barrier for floating pollutants

It has been found that the leakage of pollutants can be avoided without adding substantially to the ...

Apparatus for processing flushing liquor from coke ovens

The present invention processes flushing liquor by a construction and arrangement of an apparatus ...

Coal suspensions in organic liquids

OF THE INVENTION In the former aforementioned U.S. Patent, coal dust suspensions in water provide ...

Propagation of microbial cells on single carbon products

It is an object of the present invention is to provide an anaerobic process for propagation of ...

Fermentation process for improved oxygen utilization

OF THE INVENTION My fermentation apparatus comprises a fermentation section 1 with an upper ...

Method of conditioning flue gas

OF THE PREFERRED EMBODIMENTS The conditioners useful in the present invention are finely divided ...

Enzyme granules

What is claimed is: 1. An enzyme granule comprising a granule core of solid material carrying an ...

Process for producing yeast cells

What we claim is: 1. A process for producing yeast cells which comprises culturing aerobically a ...

DNA encoding histidyl tRNA synthetase variant from Streptococcus pneumoniae

Details

Inventors: Gentry, Daniel Robert; Greenwood, Rebecca Claire; Lawlor, Elizabeth Jane;
Assignee: SmithKline Beecham Corporation (Philadelphia, PA)
Primary Examiner: Prouty; Rebecca E.
Assistant Examiner: Hobbs; Lisa J.
Attorney, Agent or Firm: Gimmi; Edward R., King; William T., Lentz; Edward T.

The invention provides hisS polypeptides and DNA (RNA) encoding hisS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing hisS polypeptides to screen for antibacterial compounds.

DETAILED DESCRIPTION What is claimed is: 1.
An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of: (a) a polynucleotide having at least a 95% identity to a polynucleotide encoding a polypeptide comprising the amino acid sequence of the reference sequence of SEQ ID NO:2; (b) a polynucleotide having at least a 97% identity to a polynucleotide encoding a polypeptide comprising the amino acid sequence of the reference sequence of SEQ ID NO:2; (c) a polynucleotide encoding a polypeptide comprising the amino acid sequence of the reference sequence of SEQ ID NO:2; (d) a polynucleotide hybridizing under stringent conditions to a polynucleotide encoding a polypeptide comprising the amino acid sequence of the reference sequence of SEQ ID NO:2; (e) a polynucleotide having at least a 95% identity to a polynucleotide encoding the same mature polypeptide expressed by the histidyl tRNA synthetase gene contained in NCIMB Deposit No.
40771; (f) a polynucleotide having at least a 97% identity to a polynucleotide encoding the same mature polypeptide expressed by the histidyl tRNA synthetase gene contained in NCIMB Deposit No.
40771; (g) a polynucleotide encoding the same mature polypeptide expressed by the histidyl tRNA synthetase gene contained in NCIMB Deposit No.
40771; (h) a polynucleotide which is complementary to the polynucleotide of (a), (b), (c), (d), (e), (f) or (g).
2.
The isolated polynucleotide of claim 1 wherein said polynucleotide is a polynucleotide having at least a 95% identity to a polynucleotide encoding a polypeptide comprising the amino acid sequence of the reference sequence of SEQ ID NO:2.
3.
The isolated polynucleotide of claim 1 wherein said polynucleotide is a polynucleotide having at least a 97% identity to a polynucleotide encoding a polypeptide comprising the amino acid sequence of the reference sequence of SEQ ID NO:2.
4.
The isolated polynucleotide of claim 1 wherein said polynucleotide is a polynucleotide encoding a polypeptide comprising the amino acid sequence of the reference sequence of SEQ ID NO:2

Related patents

	Process for production of ascorbate oxidase What is claimed is: 1. A process for the production of ascorbate oxidase, comprising contacting plant tissue of the species Sechium edule Sw. with an aqueous alkaline ...
	Bactericidal factor in human airway surface fluid and uses thereof This invention relates to a broad spectrum antimicrobial factor which is produced by airway epithelial cells. This factor, which has been determined to be a defensin-...
	N-substituted cyclopeptide derivatives and preparation thereof We claim: 1. A process for preparing a compound of formula I ##STR4## in which R.sup.1 is lower alkyl, R.sup.2 is lower alkyl or cyclo(lower)alkyl, R.sup.3 is an amino ...
	Facile synthesis of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) I claim: 1. The preparation of 3'-phosphoadenosine 5'-phosphosulfate (IV) by a process which comprises reacting adenosine (I) with pyrophosphoryl chloride to produce ...
	Amide derivatives of acids, an antibiotic produced by Polyangium cellulosum var. fulvum The present invention relates to novel cyclic and acyclic amides obtained by structurally modifying substance known as acid S, a potent antibiotic isolated from P...
	Method for the prevention and control of epileptic seizure associated with Lennox-Gastaut syndrome What is claimed is: 1. A method for the prevention and control of seizures associated with Lennox-Gastaut syndrome which comprises administering to a warm-blooded animal ...
	Gene encoding endoglycoceramidase In order to achieve the above objects, the present inventors conducted intensive studies in an effort to isolate the DNA encoding a polypeptide possessing ...
	Apparatus for effecting clarification of liquid provided with filter cleaning means The present invention relates to the clarification of liquids and more particularly to a novel method and apparatus for effecting clarification of liquids having ...
	Pond with filtered water We claim: 1. A pond with filtered water having a relatively large and free surface, characterized in that the pond (2) is laid out along a polluted surface water (1) ...
	Method of converting brines to useful products OF THE INVENTION Referring to the FIGURE, a source of brine is introduced into tank 10 through conduit 11. If the brine in question contains significant amounts of oil, ...

0.044
Archive: All patents - Links Copyright (c)2006 Eipa-patents.org - All rights reserved