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Dental caries detection
| Details |
Inventors: Yamauchi, Junichi; Shibatani, Kyoichiro; Ikeguchi, Eiji; Omura, Ikuo; Nagase, Yoshinori;
Assignee: Kuraray Company, Limited (Kurashiki, JP)
Primary Examiner: Fagelson; Anna P.
Assistant Examiner:
Attorney, Agent or Firm: Oblon, Fisher, Spivak, McClelland & Maier
A caries detector, comprising a solution of a dye selected from the group consisting of Phloxine B (CI 45410), Phloxine BK (the corresponding dipotassium salt of CI 45410), Acid Red (CI 45100), Fast Acid Magenta (CI 17200), Fast Green FCF (CI 42053) and Rhodamine B (CI 45170) in a solvent. |
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DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS By chemical nomenclature, the dyes employed in the formulation of the caries detector of the present invention are as follows: (1) Phloxine B (CI 45410) (Generic name, CI Acid Red 92) Disodium salt of 9-(3,4,5,6-tetrachloro-ortho-carboxy-phenyl)-6-hydroxy-2,4,5,7-tetrabromo- 3-isoxanthone.
(2) Phloxine BK (the corresponding dipotassium salt of CI 45410) Dipotassium salt of 9-(3,4,5,6-tetrachloro-ortho-carboxyphenyl)-6-hydroxy-2,4,5,7-tetrabromo-3 -isoxanthone.
(3) Acid Red (CI 45100) (CI Acid Red 52) Monosodium salt of 9-(4-sulfo-2-sulfoniumphenyl)-6-diethylamino-3-(N,N-diethylimino)-3-isoxan thene.
(4) Fast Acid Magenta (CI 17200) (CI Acid Red 33) Disodium salt of 8-amino-2-phenylazo-1-naphthol-3,6-disulfonic acid.
(5) Fast Green FCF (CI 42053) (CI Food Green 3) Disodium salt of 4-{[4-(N-ethyl-meta-sulfobenzylamino)-phenyl]-(4-hydroxy-2-sulfoniumphenyl )-methylene}-[1-(N-ethyl-N-meta-sulfobenzyl).
DELTA.
.
sup.
2.
5 -cyclohexadienimine].
(6) Rhodamine B (CI 45170) (CI Basic Violet 10) 3-Ethochloride of 9-ortho-carboxyphenyl-6-diethylamino-3-ethylimino-3-isoxanthene.
The caries detector of this invention is prepared by dissolving at least one of the above dyes in a solvent.
The concentration of the dye in the solution is preferably 0.
1 to 5% by weight.
If the concentration is less than 0.
1% by weight, the resulting caries detector does not permit sufficient coloration of a dental caries.
If the concentration is greater than 5% by weight, the coloration of the detector extends even to the sound dental portion, thereby rendering it difficult to detect solely the carious portion of the tooth.
Preferably, the concentration of the dye in the solution is 1 to 2% by weight.
By the use of the specified dyes, the caries detector of the present invention can clearly color only the carious portion of a tooth, and therefore, the carious portion can be clearly differentiated from the sound portion.
Rhodamine B and Acid Red are especially preferred dyes.
These particular dyes are officially approved in Japan as highly safe dyes for foodstuffs and for medicines that can be applied to the mucous membrane
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Molecular Biology 
