Dihydroxyphenylethylaminoalkyl theophyllines

DETAILED DESCRIPTION What is claimed is: 1.
A compound corresponding to the general formula ##STR6## in which T is the theophyllin-7-yl radical and alk is an alkylene chain with 3 carbon atoms, or a pharmaceutically acceptable salt thereof.
2.
A compound according to claim 1 in the form of the free base.
3.
A compound according to claim 1 in the form of a pharmaceutically acceptable salt.
4.
A method of increasing renal circulation in a mammal comprising administering to the mammal an effective amount to increase renal circulation of a compound corresponding to the general formula ##STR7## in which T is the theophyllin-7-yl radical and alk is an alkylene chain with 2 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof.
5.
A method according to claim 4 wherein the compound is 7-{3-[3,4,-dihydroxyphenyl)-ethylamino]-propyl}-theophylline.
6.
A method according to claim 4 wherein alk is ##STR8## 7.
A method according to claim 6 wherein the compound is 7-{2-[2-(3,4-dihydroxyphenyl)-ethylamino]-ethyl}-theophylline.
8.
A compound according to claim 6 which is 7-{3-[2-(3,4-dihydroxyphenyl)-ethylamino]-propyl}-theophylline.
9.
A method according to claim 6 wherein the compound is 7-{3-[2-(3,4-dihydroxyphenyl)-ethylamino]-butyl}-theophylline.
10.
A method according to claim 4 wherein there is administered orally at least 0.
1 mg/kg body weight of the mammal.
11.
A method according to claim 4 wherein there is administered intravenously at least 0.
001 mg/kg body weight of the mammal.




Description:
BACKGROUND OF THE INVENTION This invention relates to new basically substituted theophylline derivatives.
Klingler German Patent Specification No.
1,221,641 described the production of theophylline derivatives corresponding to the general formula ##STR2## in which T represents theophylline radical, Alk represents a straight or branched alkylene chain with 2 to 6 carbon atoms, R represents a hydrogen atom or a lower alkyl group and A represents a phenyl radical which is substituted once, twice or three times by hydroxyl, methoxy, alkyl, aralkyl or alkoxy alkyl groups with 1 to 3 carbon atoms in the alkyl radical or by chlorine or bromine atoms or once by a methylene dioxy group in the 3,4-position