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Home Molecular Biology Fungicidal-agents-LL-15G256-gamma-delta-and-epsilon-produced-by-LL-15G256-Hypoxylon-oceanicum

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 Fungicidal agents LL-15G256.gamma.,.delta., and .epsilon. produced by LL-15G256 (Hypoxylon oceanicum)

Details
Inventors: Schlingmann, Gerhard; Milne, Lisa; Pearce, Cedric J.; Jones, E. B. Gareth; Albaugh, David A.;
Assignee: American Cyanamid Company (Madison, NJ)
Primary Examiner: Lankford, Jr.; Leon B.
Assistant Examiner: Tate; Christopher R.
Attorney, Agent or Firm: Costello, Jr.; Charles F.

This invention provides new antifungal compounds of Formula I or II: ##STR1## wherein R, R.sup.1 and R.sup.2 are defined in the specification produced by culture LL-15G256 (Hypoxylon oceanicum), NRRL 21363 and their production by fermentation and use as antifungal agents.

DETAILED DESCRIPTION The invention provides to the art novel antifungal compounds of Formula I and II: ##STR2## ##STR3## wherein n is 3 to 10; R is hydrogen, C.
sub.
1 -C.
sub.
4 alkyl or a pharmaceutically acceptable salt cation selected from the group consisting of sodium, potassium, calcium, lithium, magnesium, ammonium and tetra(C.
sub.
1 -C.
sub.
4)alkyl ammonium; R.
sup.
1 is hydrogen or methyl; and R.
sup.
2 is hydrogen or methyl.
This invention also provides a process for producing the antifungal compounds of Formula I and II by aerobically fermenting the fungus LL-15G256, NRRL 21363; a biologically pure culture of the fungus LL 15G256, NRRL 21363; composition containing the compounds of Formula I and II, and methods for the protection of plants from plant pathogenic fungi.



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