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| Fungicidal agents LL-15G256.gamma.,.delta., and .epsilon. produced by LL-15G256 (Hypoxylon oceanicum) |
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| Soil conditioners |
| OF THE PREFERRED EMBODIMENTS The soil conditioner of the present invention comprises 4 to 4.75 ... |
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| Method for the manufacture of fodder and/or soil improving agents from waste material |
| OF THE INVENTION The method according to the invention, basically, resides in that the ... |
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Human T or B cell lines and a process for producing immunologically active substances using the same
| Details |
Inventors: Takano, Satoshi; Morioka, Hajimu; Shibai, Hiroshiro; Onodera, Kazukiyo;
Assignee: Ajinomoto Co., Inc. (Tokyo, JP)
Primary Examiner: Weimar; Elizabeth
Assistant Examiner:
Attorney, Agent or Firm: Oblon, Fisher, Spivak, McClelland & Maier
This invention relates to a human T or B cell line carrying at least one Ela human adenovirus 12-type gene or fragment thereof; said cell line being capable of spontaneously producing an immmunologically active substance. This invention also relates to a process for producing an immunologically active substance comprising culturing a human B- or T- cell line carrying at least one human Ela adenovirus 12-type gene or fragment thereof in a culture medium capable of supporting growth thereof for a period of time effective to attain a spontaneous production of the substance thereof. |
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DETAILED DESCRIPTION What is claimed as new and desired to be secured by letters patent of the United States is: 1.
A human T or B cell line selected from the group consisting of Jurkat cells and Namalwa cells carrying at least one E1a Human adenovirus 12-type gene; said cell line being capable of constitutively producing an immunologically active substance selected from the group consisting of .
alpha.
-, .
beta.
- or .
gamma.
-interferon, interleukin-2, interleukin-1, B cell growth factor and CSF.
2.
The cell line of claim 1, which is Jurkat-MTE-31-12.
3.
The cell line of claim 1, which is Jurkat-MTE-23.
4.
The cell line of claim 1, which is a Namalwa cell.
5.
A process for producing an immunologically active substance comprising culturing a human B- or T-cell line selected from the group consisting of Jurkat cells and Namalwa cells carrying at least one human E1a adenovirus 12-type gene, in a culture medium capable of supporting growth thereof for a period of time effective to attain constitutive production of the substance thereof, wherein said substance is selected from the group consisting of .
alpha.
-, .
beta.
- or .
gamma.
-interferon, interleukin-2, interleukin-1, B cell growth factor and CSF.
6.
A process according to claim 5, wherein said cell line is selected from the group consisting of Jurkat-MTE-23 and Jurkat-MTE-31-12.
Description:
BACKGROUND OF THE INVENTION 1.
Field of the Invention The present invention relates to improved human T or B cell lines and a process for producing immunologically active substances using the same.
2.
Discussion of Background It has heretofore been known that human T and B cell lines are stimulated by immunologically active substance inducers such as lectin, etc.
to produce soluble, immunologically active substances such as .
alpha.
-, .
beta.
- or .
gamma.
-interferons, interleukin-2, interleukin-1, B cell growth factor, CSF, etc.
In most cases, however, these human T and B cell lines will not produce immunologically active substances unless they are stimulated by immunologically active substance inducers such as phorbol ester, lectin, etc
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Molecular Biology 
