 Concentrated heavy duty particulate laundry detergent |
| What is claimed is: 1. A free flowing particulate heavy duty laundry detergent of bulk density of ... |
|
| Anaerobic digestion process for organic wastes |
| The objective of the present invention is to eliminate the aforementioned drawbacks of the ... |
|
| Transport medium for microorganisms |
| The embodiments of the invention in which an exclusive property or privilege is claimed are defined ... |
|
| Antibodies which catalyze hydrolysis of ester bonds |
| The present invention contemplates a receptor molecule that contains an antibody combining site or ... |
|
| Inhibition of trichothecene toxins by ancymidol |
| OF THE INVENTION The name "ancymidol" is generic for .alpha.-cyclopropyl-.alpha.-(p-methoxyphenyl)-... |
|
| Microbial rennin |
| What is claimed is: 1. A microbial rennin having relatively high milk coagulating activity and ... |
|
| Concentrated GTF chromium complex brewers yeast and process for producing same |
| What is claimed is: 1. A method for concentrating the naturally occurring GTF chromium complex in a ... |
|
| Method and unit for wastewater treatment by microorganisms |
| OF THE INVENTION The wastewater which can be treated in this invention comprises aqueous liquids ... |
|
| Machine and process for reading cards containing medical specimens |
| Referring now to the drawings, a microbial analyzing machine A (FIG. 1) examines cuvettes or cards ... |
|
|
Hypotensive active peptides
| Details |
Inventors: Pang, Peter K. T.; Tenner, Jr., Thomas E.;
Assignee: Texas Tech University Health Sciences Center (Lubbock, TX)
Primary Examiner: Phillips; Delbert R.
Assistant Examiner:
Attorney, Agent or Firm: Arnold, White & Durkee
The present invention provides a hypotensive composition comprising a peptide having the structure X-Y, Y-X, or a salt thereof, wherein X is proline or proline-proline and Y is arginine, lysine, arginine-arginine, lysine-lysine, arginine-lysine, or lysine-arginine, together with a pharmaceutically suitable diluent. |
|
DETAILED DESCRIPTION OF THE INVENTION This invention provides a series of 24 small peptides, two to four amino acids in length, which represent a new class of therapeutically useful antihypertensive agents.
The general structure of the peptides included in the present invention can be defined as XY or YX, where X is proline (Pro) or proline-proline; and Y is arginine (Arg), lysine (Lys), arginine-arginine, lysine-lysine, arginine-lysine, or lysine-arginine.
This yields the following 24 possible combinations:
______________________________________
XY YX
______________________________________
Pro--Arg Arg--Pro
Pro--Lys Arg--Pro--Pro
Pro--Arg--Arg Lys--Pro
Pro--Lys--Lys Lys--Pro--Pro
Pro--Arg--Lys Arg--Arg--Pro
Pro--Lys--Arg Arg--Arg--Pro--Pro
Pro--Pro--Lys Lys--Lys--Pro
Pro--Pro--Arg--Arg Lys--Lys--Pro--Pro
Pro--Pro--Lys--Lys Arg--Lys--Pro
Pro--Pro--Arg--Lys Lys--Arg--Pro
Pro--Pro--Lys--Arg Lys--Arg--Pro--Pro
Pro--Pro--Arg Arg--Lys--Pro--Pro
______________________________________
The compositions of the present invention may be synthesized by known polypeptide synthesis methods.
These peptides are then administered to the hypertensive mammal in a suitable diluent, such as normal saline, the peptide in an amount effective to reduce the mammal's blood pressure.
The present invention may be better understood by reference to the following examples.
EXAMPLE 1 Corticotropin Inhibiting Peptide (CIP) contains the following amino acid sequence, the underlined sequences of which are the sequences which are the subject of the present invention: Human CIP (ACTH 7-38): Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-As n-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu [M.
W.
3659.
68] This CIP fragment was obtained from the Peninsula Laboratories, San Carlos, CA.
When administered to dogs, this peptide resulted in dose-related hypotension.
The dog blood pressure assay was conducted according to the following method: Mongrel dogs of either sex weighing between 6-15 kg were anesthetized by intravenous injection of sodium pentobarbital (30 mg/kg)
|
|
Molecular Biology 
