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In vitro detection of gastrointestinal cancer
| Details |
Inventors: Linnane, Anthony W.;
Assignee: Mucan Diagnostics Pty., Ltd. (Victoria, AU)
Primary Examiner: Rosen; Sam
Assistant Examiner:
Attorney, Agent or Firm: Cushman, Darby & Cushman
An in vitro diagnostic method for detecting the presence in a patient of cancer cells or other cells producing mucin antigens comprises the step of testing a sample of a physiological fluid, particularly a sample of blood, blood serum or blood plasma, taken from the patient to detect the presence of small intestine mucin antigen (SIMA) and/or large intestine mucin antigen (LIMA) in the sample. An in vitro diagnostic kit is also disclosed. |
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DETAILED DESCRIPTION I claim: 1.
An in vitro diagnostic method for detecting the presence in a patient of cancer cells or other cells producing mucin antigens, which method comprises the step of testing a sample of a physiological fluid selected from the group consisting of blood, blood serum and blood plasma taken from the patient to detect the presence of SIMA and/or LIMA in said sample.
2.
A method according to claim 1, comprising the steps of contacting said sample with antibodies to SIMA and/or LIMA or fragments thereof, and detecting the presence of the binding of said antibodies or fragments thereof to their corresponding antigens.
3.
A method according to claim 1, comprising the steps of contacting said sample with antibodies to SIMA and/or LIMA or fragments thereof labelled with a label capable of providing a detectable signal, and detecting the presence of the binding of said labelled antibodies or fragments thereof to their corresponding antigens.
4.
A method according to claim 2, wherein said antibodies are monoclonal antibodies.
5.
A method according to claim 2 wherein said antibodies or fragments thereof are labelled with an enzyme or radioisotope.
6.
A method according to claim 1, comprising the steps of: (i) linking antibodies to SIMA and/or LIMA, or fragments thereof, to a solid support; (ii) contacting said sample with said solid support; and (iii) detecting the presence of corresponding antigens in said sample bound to said antibodies or fragments thereof linked to said solid support.
7.
A method according to claim 6, wherein said step of detecting the presence of bound corresponding antigens comprises: (iv) contacting said solid support with antibodies to SIMA and/or LIMA, or fragments thereof, labelled with a label capable of providing a detectable signal; and (v) detecting the binding of said labelled antibodies or fragments thereof to corresponding antigen bound to said solid support.
Description:
This invention relates primarily to methods and systems for the diagnosis of mucinous cancers, particularly cancer of the gastrointestinal tract, as well as cancer of the breast, lung, stomach, ovary, and the like
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Molecular Biology 
