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Melanin inhibiting cosmetic composition
| Details |
Inventors: Higa, Yoshitaka;
Assignee: Sansho Seiyaku Co., Ltd. (Fukuoka, JP)
Primary Examiner: Brown; Johnnie R.
Assistant Examiner: Stone; Jacqueline M.
Attorney, Agent or Firm: Jordan and Hamburg
Placenta extracts and kojic acid or kojic acid derivatives are formulated into cosmetic bases to make cosmetic compositions. The cosmetic compositions exhibit an enhanced whitening effect for the skin due to the action of the placenta extract and kojic acid or kojic acid derivatives. |
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DETAILED DESCRIPTION OF THE INVENTION The placenta extracts which are employed in the present invention are aqueous solutions obtained by extracting water-soluble portions with water via means of washing placenta of human or animals such as cows, etc.
, withdrawing blood therefrom, crushing, freezing, etc.
and, further removing impurities from the extract.
The thus obtained extracts are commercially available as placenta extracts and used mainly as raw materials for cosmetics.
These placenta extracts may be any of those derived from human and derived from animals such as cows, etc.
but the human-derived placenta extracts are preferred.
An exemplary mode of preparing a human placenta extract suitable for use in the present invention, as disclosed in Published Examined Japanese Patent Application No.
15399/60, comprises: (A) sterilizing and then removing blood from human placenta, washing with a physiological saline solution and freezing; (B) destroying the constituent cell wall; (C) heating the exduded cell liquid at 80.
degree.
-100.
degree.
C.
, removing the precipitate and then removing precipitate by centrifugation; (D) sterilizing the supernatant liquid and allowing in a cool and dark room after separating the precipitate with ethanol; (E) vacuum drying the precipitate and dissolving with distilled water; and (F) separating the solution by centrifugation and collecting the placentin.
Examples of the kojic acid derivatives used in the present invention include monofatty acid esters of kojic acid, for example, kojic acid monopalmitate, kojic acid monobutyrate, kojic acid monocaprylate and kojic acid monostearate (disclosed in Published Unexamined Japanese Patent Application No.
77272/81); difatty acid esters of kojic acid, for example, kojic acid dipalmitate, kojic acid dibutyrate, kojic acid dioleate and kojic acid distearate (disclosed in Published Unexamined Japanese Patent Application No.
7776/81); and, in addition thereto, kojic acid monocinnamoate, kojic acid monobenzoate, etc.
(disclosed in Published Unexamined Japanese Patent Application No
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Molecular Biology 
