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Method for producing D-.alpha.-amino acid
| Details |
Inventors: Nakamori, Shigeru; Yokozeki, Kenzo; Mitsugi, Koji; Eguchi, Chikahiko; Iwagami, Hisao;
Assignee: Ajinomoto Company, Incorporated (Tokyo, JP)
Primary Examiner: Warden; Robert J.
Assistant Examiner:
Attorney, Agent or Firm: Oblon, Fisher, Spivak, McClelland & Maier
D-.alpha.-amino acids are produced by contacting a 5-substituted hydantoin with an effective amount of an enzyme capable of converting the 5-substituted hydantoin to the D-.alpha.-amino acid produced by a microorganism in an aqueous medium at a pH in the range of 4 to 9, the microorganism being capable of utilizing the D-isomer of the 5-substituted hydantoin as the sole nitrogen source, but substantially incapable of utilizing the L-isomer of the 5-substituted hydantoin as the nitrogen source and the substituent of the 5-position being such that upon reaction with the enzyme, an optically active D-.alpha.-amino acid isomer is produced; and recovering the D-.alpha.-amino acid which accumulates in the aqueous medium. |
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DETAILED DESCRIPTION What is claimed as new and intended to be secured by Letters Patent is: 1.
A method for producing a D-.
alpha.
-amino acid, which comprises: contacting a 5-substituted hydantoin with an effective amount of an enzyme capable of converting the 5-substituted hydantoin directly to the D-.
alpha.
-amino acid, produced by a microorganism belonging to the genus Pseudomonas, Achromobacter, Alcaligenes, Moraxella, Paracoccus or Anthrobacter, in an aqueous medium at a pH in the range from 4 to 9, said microorganism being capable of utilizing the D-isomer of said 5-substituted hydantoin as the sole nitrogen source, but substantially incapable of utilizing the L-isomer of said 5-substituted hydantoin as the nitrogen source and the substituent of said 5-position being such that upon reaction with said enzyme, an optically active D-.
alpha.
-amino acid isomer is produced; and recovering the D-.
alpha.
-amino acid which accumulates in the aqueous medium.
2.
The method of claim 1, wherein the microorganism is Pseudomonas solanacearum AJ 11149 (NRRL B-11,255), Pseudomonas caryophilli AJ 11150 (NRRL B-11,256), Pseudomonas diminuta AJ 11151 (NRRL B-11,257), Pseudomonas diminuta AJ 11152 (NRRL B-11,258), Achromobacter liquefaciens AJ 11198 (NRRL B-11,259), Alcaligenes aquamarinus AJ 11199 (NRRL B-11,260), Moraxella nonliquefaciens AJ 11221 (NRRL B-11,261), Paracoccus denitrificans AJ 11222 (NRRL B-11,262), or Arthrobacter fragilus AJ 11223 (NRRL B-11,263).
3.
The method of claim 1, wherein the enzyme is produced by culturing the microorganism in an aqueous culture medium containing at least one 5-substituted hydantoin.
4.
The method of claim 1, wherein the 5-substituted-hydantoin is a 5-alkyl hydantoin.
5.
The method of claim 1, wherein the 5-substituted-hydantoin is a 5-(substituted alkyl) hydantoin.
6.
The method of claim 1, wherein the 5-substituted-hydantoin is a 5-aryl-hydantoin.
7.
The method of claim 1, wherein the 5-substituted-hydantoin is a 5-(substituted-aryl)-hydantoin.
8.
The method of claim 1, wherein the 5-substituted-hydantoin is a 5-aralkyl hydantoin
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Molecular Biology 
