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Phenyl 5Z,8Z,11Z,14Z-eicosatetraenoate and congeners
| Details |
Inventors: Liang, Chi-Dean;
Assignee: G. D. Searle & Co. (Skokie, IL)
Primary Examiner: Niebling; John F.
Assistant Examiner:
Attorney, Agent or Firm: Henes; James R., Brown; John M.
Preparation and use of platelet aggregation inhibiting and antisecretory phenyl 5Z,8Z,11Z,14Z-eicosatetraenoate and congeners are disclosed. |
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DETAILED DESCRIPTION What is claim is: 1.
A compound of the formula wherein R' represents hydrogen, 2-alkyl containing fewer than 3 carbons, or 3methyl; R" represents hydrogen or 2-alkyl containing fewer than 3 carbons except when R' represents 3-methyl, in which circumstance R" represents solely hydrogen; and Ph represents phenyl substituted by fewer than 4 2.
A compound according to claim 1 having the formula ##STR29## wherein Ph represents phenyl substituted by fewer than 4 alkyls each containing fewer than 5 carbons.
3.
A compound according to claim 1 having the formula ##STR30## where R represents alkyl containing fewer than 5 carbons.
4.
A compound according to claim 1 which is 4-(1,1-dimethylethyl)phenyl 5Z,8Z,11Z,14Z-eicosatetraenoate.
5.
A compound according to claim 1 having the formula ##STR31## wherein R represents alkyl containing fewer than 3 carbons and Ph represents phenyl substituted by fewer than 4 alkyls each containing fewer than 5 carbons.
6.
A compound according to claim 1 which is 4-(1,1-dimethylethyl)phenyl 2methyl-5Z,8Z,11Z,14Z-eicosatetraenoate.
7.
A compound according to claim 1 having the formula ##STR32## wherein R represents alkyl containing fewer than 3 carbons and Ph represents phenyl substituted by fewer than 4 alkyls each containing fewer than 5 carbons.
8.
A compound according to claim 1 which is 4-(1,1-dimethylethyl)phenyl 2,2-dimethyl-5Z,8Z,11Z,14Z-eicosatetraenoate.
9.
A compound according to claim 1 having the formula ##STR33## wherein Ph represents phenyl substituted by fewer than 4 alkyls each containing fewer than 5 carbons.
10.
A compound according to claim 1 which is 4-(1,1-dimethylethyl)phenyl 3-methyl-5Z,8Z,11Z,14Z-eicosatetraenoate.
Description:
This invention relates to phenyl 5Z,8Z,11Z,14Z-eicosatetraenoate and congeners, and to processes for the preparation thereof.
More particularly, this invention provides new, pharmacologically useful, and unobvious chemical compounds of the formula ##STR1## wherein R' represents hydrogen, 2-alkyl or 3-alkyl; R" represents hydrogen or 2-alkyl except when R' represents 3-alkyl, in which circumstance R' represents solely hydrogen; Z represents phenyl optionally substituted by 1 or more alkyls; and the dotted lines signify that a 5Z double bond or 5Z and 17Z double bonds can be present
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Molecular Biology 
