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Process-for-recovering-L-amino-acids-from-fermentation-liquors-containing-them

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Process for recovering L-amino acids from fermentation liquors containing them

Details

Inventors: Miyazawa, Masashi; Kaneko, Toyokazu; Kaneko, Tetsuya; Yarita, Kenich; Mori, Shigenori; Iitani, Kinzo; Yamamoto, Masaki;
Assignee: Ajinomoto Co., Inc. (Tokyo, JP)
Primary Examiner: Warden; Robert J.
Assistant Examiner: McMahon; Timothy M.
Attorney, Agent or Firm: Oblon, Spivak, McClelland, Maier & Neustadt

A process for recovering a high-purity L-amino acid from a fermentation liquor obtained by fermentation or an enzymic method, which comprises removing the impurities contained in said fermentation liquor by passing said fermentation liquor through an ultrafilter membrane and then through an ion-exchange or adsorbent resin; concentrating or cooling the effluent thus obtained to result in crystallization of said L-amino acid, and isolation said crystalline L-amino acid from said fermentation liquor.

DETAILED DESCRIPTION Accordingly, it is an object of the present invention to develop a technique capable of removing both microbial cells and polymeric impurities from fermentation liquors used to produce amino acids.
It is yet another object of the present invention to develop a technique to remove substances that are responsible for retardation of crystal growth and low purity of separated amino acid crystals.
It is yet another object of the present invention to establish a simple process for recovering high purity crystals of L-amino acids which eliminates the need for ion exchange.
According to the present invention, high purity crystals of an amino acid can be recovered from fermentation liquors by a simple process if the impurities contained therein are removed by passing the fermentation liquor through an ultrafiltration membrane and then through an ion-exchange or adsorbent resin, followed by concentration or cooling of the effluent thus obtained.

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