Process for the preparation of L-car-bamyl-amino acids and of the corresponding L-amino acids

DETAILED DESCRIPTION What we claim is: 1.
A process for the preparation of only one of the two stereoisomer forms of carbamylamino acids comprising: a.
subjecting to hydrolysis a racemic mixture of compounds of the formula ##EQU4## wherein X is selected from the group consisting of CO, CS and O, R is selected from the group consisting of hydrogen and hydrocarbon radicals having up to 8 carbon atoms, R.
sub.
1 is the residue of an amino acid molecule wherefrom the ##EQU5## moiety has been removed, said hydrolysis being carried out in the presence of an enzyme which acts on the racemic mixture through a selective hydrolysis of only one of the optically active forms: b.
separating the sole resultant carbamyl amino acid stereoisomer.
2.
The process of claim 1 further comprising the steps of: c.
racemizing the hydrolysis product remaining after said carbamyl amino acid is separated, and d.
subjecting the racemic mixture resulting from step (c) to hydrolysis in the presence of an enzyme used in step (a); and e.
separating the sole resultant carbamyl amino acid stereoisomer.
3.
The process of claim 1 which further comprises the step of converting said carbamyl amino acid stereoisomer obtained to the corresponding amino acid.
4.
The process of claim 2 which further comprises the step of converting said carbamyl amino acid stereoisomer obtained to the corresponding amino acid.
5.
The process of claim 1 wherein X is CO.
6.
The process of claim 2 wherein X is CO.
7.
The process of claim 2 wherein said enzyme is dihydropyrimidinase extracted from calf liver.
8.
The process according to claim 2 wherein X is CO; said racemizing in step (c) is carried out in an aqueous solution at a racemizing temperature and at a pH above 7.
9.
The process according to claim 1 wherein said enzymes are bound to a carrier or englobed in a fibrous carrier.
10.
The process according to claim 3 wherein said carbamyl amino acid is converted into the corresponding amino acid by heating said carbamyl amino acid in an aqueous solution and gradually adding thereto an equimolecular amount of an acid