Prostaglandin intermediate

DETAILED DESCRIPTION What is claimed is: 1.
The compound which is 7-[5.
alpha.
-hydroxy-3.
alpha.
-methyl-2.
beta.
-(3-oxo-trans-1-octenyl) -1.
alpha.
-cyclopentyl]-cis-5-heptenoic acid.




Description:
BACKGROUND OF THE INVENTION The control of bleeding during surgery is of considerable importance for the prevention of blood loss and the maintenance of a clear surgical field.
For the prevention of gross bleeding from an exposed severed large artery or vein, where there is considerable intravasculr pressure, mechanical means, such as pressure or clamping, or cauterization are employed.
For the control of bleeding from small blood vessels, where intravascular pressure does not prevent clotting, various methods may be used.
One method comprises the topical application of thrombin to the wound surface whereby clotting is promoted by direct action of the thrombin of fibrinogen.
Other methods employ substances which arrest bleeding by providing a mechanical matrix that facilitates clotting.
Various absorbable substances used for this purpose are absorbable gelatin sponge (Gelfoam); oxidized cellulose (oxycel), or fibrin foam.
A combination of such substances with thrombin (e.
g.
by saturating a pad of the absorbable substance with a thrombin solution) is especially effective.
The present invention provides an improved method for the attenuation of bleeding at a wound surface.
The method comprises the topical application to the wound surface of an effective amount of prostaglandin derivative selected from the group consisting of: A.
7-(5.
alpha.
-hydroxy-2.
beta.
-[(3RS)-3-hydroxy-3-methyl-trans-1-octenyl]-3.
a lpha.
-methyl-1.
alpha.
-cyclopentyl)cis -5-heptenoic acid; B.
7-(5.
alpha.
-hydroxy-2.
beta.
-[(3RS)-classes: -hydroxy-3-methyl-trans-1-octenyl ]-1.
alpha.
-cyclopentyl)-cis-5-heptenoic acid; and C.
7-(2.
beta.
-[(3RS)-hydroxy-3-methyl-trans-1-octenyl]-5-oxo-1.
alpha.
-cyclope ntyl)-cis-5-heptenoic acid.
The invention also contemplates the novel chemical compound: 7-(5.
alpha.
-hydroxy-2.
beta.
-[(3RS)-3-hydroxy-3-methyl-trans-1-octenyl]-3