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Solid consumer product compositions containing small particle clyclodextrin complexes
| Details |
Inventors: Trinh, Toan; Gardlik, John M.;
Assignee: The Procter & Gamble Company (Cincinnati, OH)
Primary Examiner: Reamer; James H.
Assistant Examiner:
Attorney, Agent or Firm: Aylor; Robert B.
An effective amount of active/cyclodextrin complex, in the form of particles having particle sizes below about 12 microns, is incorporated into solid consumer product compositions. The complexes provide fast release of the active when they are wetted even when the amount of water available to effect release of the active is limited as in personal use compositions like drugs, foods, and cosmetics where active release is typically effected by body fluids. Preferred actives include perfumes, flavors, and pharmaceutical materials that are used by consumers. |
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DETAILED DESCRIPTION What is claimed is: 1.
Pharmaceutical composition comprising an effective amount of active/cyclodextrin inclusion complex with pharmaceutical agent selected from the group consisting of: ibuprofen; acetylsalicylic acid; salts of acetylsalicylic acid; acetamidophen; apomorphine; butylated hydroxytoluene; chlorthalidone; cholecalciferol; dexamethasone; dicumarol; digoxin; diphenylhydantoin; estradiol; estriol; ethinylestradiol-3-methyl ether; ethisterone; furosemide; hydroflumethiazide; indomethacin; iproniazid phosphate; 17-methyltestosterone; nitroglycerin; norethindrone; oubain; oxprenolol; progesterone; retinal; trans-retinoic acid: salts of trans-retinoic acid: retinol; spironolactone; sulpiride; testosterone; theophylline; aryclovir; cloridine HCl; and mixtures thereof, said complex being prepared by the kneading method and having a particle size of less than about 5 microns which provides for fast release of said pharmaceutical agent.
2.
The composition of claim 1 wherein at least a major portion of said cyclodextrin is selected from the group consisting of alpha-cyclodextrin; beta-cyclodextrin; gamma-cyclodextrin; and mixtures thereof.
3.
The composition of claim 1 wherein at least a major portion of said cyclodextrin is beta-cyclodextrin.
4.
The composition of claim 3 wherein said pharmaceutical agent is acetamidophen.
5.
The composition of claim 3 wherein said pharmaceutical agent is ibuprofen.
6.
The composition of claim 3 wherein said pharmaceutical agent is acetylsalicylic acid.
7.
The composition of claim 3 wherein said pharmaceutical agent is a mixture of said agents.
Description:
TECHNICAL FIELD The present invention relates to an improvement in solid consumer products (compositions) containing solid cyclodextrin inclusion complexes of actives, which are typically hydrophobic materials like perfumes, flavoring materials, pharmaceutical actives, antibacterials, bleaches, etc.
, said products, and/or compositions, being, preferably, either in particulate form; compounded with other materials in solid form, e
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Molecular Biology 
