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Home Molecular Biology Substituted-triazino-benzimidazoles

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 Substituted triazino-benzimidazoles

Details
Inventors: Rochling, Hans; Hartel, Kurt; Kirsch, Reinhard; Duwel, Dieter;
Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DT)
Primary Examiner: Ford; John M.
Assistant Examiner:
Attorney, Agent or Firm: Curtis, Morris & Safford

The present invention relates to triazinobenzimidazoles and to a process for their preparation. The compounds are chemotherapeutics and are suitable for combating parasitary diseases in humans and animals; they are especially active against nematodes.

DETAILED DESCRIPTION What we claim is: 1.
A triazinobenzimidazole of the formula ##STR36## wherein R.
sub.
1 is straight-chain or branched alkyl having 1 to 18 carbon atoms; straight-chain or branched alkenyl having 3 to 18 carbon atoms; cycloalkyl having 3 to 12 carbon atoms; cycloalkyl having 3 to 12 carbon atoms and substituted by at least one alkyl having 1 to 4 carbon atoms or by hydroxy; tricyclo-[5,2,1,0.
sup.
2,6 ]-decyl; phenylalkyl or diphenylalkyl each having 1 to 6 carbon atoms in the alkyl; phenyl-substituted phenylalkyl or phenyl-substituted diphenylalkyl each having 1 to 6 carbon atoms in the alkyl and in which the substituents in the phenyl are halogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or alkylthio having 1 to 4 carbon atoms; phenyl; phenyl substituted by alkyl having 1 to 4 carbon atoms, halogen, halogenoalkyl having 1 to 4 carbon atoms, hydroxyl, alkoxy having 1 to 4 carbon atoms, phenoxy, or alkylthio having 1 to 4 carbon atoms; naphthyl; naphthyl substituted by alkyl having 1 to 4 carbon atoms, halogen, halogenoalkyl having 1 to 4 carbon atoms, hydroxyl, alkoxy having 1 to 4 carbon atoms, phenoxy, or alkylthio having 1 to 4 carbon atoms; furfuryl; or R.
sub.
1 is hydroxyalkyl, alkoxyalkyl, polyalkoxyalkyl, alkyl mercaptoalkyl, dialkyl phosphinyl alkyl, morpholino alkyl, pyrrolidino alkyl, piperidino alkyl, or carbalkoxy alkyl each having 2 to 12 carbon atoms; or R.
sub.
1 is dialkylaminoalkyl of the formula ##STR37## wherein R is straight-chain or branched alkylene having 2 to 6 carbon atoms and R' and R" are the same or different alkyl having 1 to 4 carbon atoms; or is 1',1' -dialkyl-substituted propin-2'-yl of the formula ##STR38## wherein R' and R", taken alone, are alkyl having 1 to 4 carbon atoms, phenyl, or substituted phenyl, or wherein R' and R", taken together, are 5- to 8-membered cycloalkyl substituted by alkinyl having 2 to 3 carbon atoms, or are bicycloheptenyl methyl, exo-bicycloheptylmethyl, endo-bicycloheptylmethyl, bicycloheptyl or tricyclo-decenyl; R



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