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Sulphonic acid salts of S-adenosilmethionine
| Details |
Inventors: Fiecchi, Alberto;
Assignee: Bioresearch Limited (Milan, IT)
Primary Examiner: Coughlan, Jr.; Paul M.
Assistant Examiner:
Attorney, Agent or Firm: Stevens, Davis, Miller & Mosher
Stable salts of S-adenosil-L-methionine (SAM) with sulphonic acids chosen from the group consisting of methanesulphonic, ethanesulphonic, 1-n-dodecanesulphonic, 1-n-octadecanesulphonic, 2-chloroethanesulphonic, 2-bromoethanesulphonic, 2-hydroxyethanesulphonic, 3-hydroxypropanesulphonic, d-, 1, -d, 1-10-camphorsulphonic, d-, 1-, d, 1-3-bromocamphor-10-sulphonic, cysteic, benzenesulphonic, p-chlorobenzenesulphonic, 2-mesitylbenzenesulphonic, 4-biphenylsulphonic, 1-naphthalenesulphonic, 2-naphthalenesulphonic, 5-sulphosalicylic, p-acetylbenzenesulphonic, 1,2-ethanedisulphonic, o-benzenedisulphonic and chondroitinesulphuric acids, and double salts of said acids with sulphuric acid. |
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DETAILED DESCRIPTION I claim: 1.
Stable salts of S-adenosil-L-methionine (SAM) with sulphonic acids selected from the group consisting of methanesulphonic, ethanesulphonic, 1-n-dodecanesulphonic, 1-n-octadecanesulphonic, 2-chloroethanesulphonic, 2-bromoethanesulphonic, 2-hydroxyethanesulphonic, 3-hydroxypropanesulphonic, d-,1-,d,1-10-camphorsulphonic, d-,1-,d,1-3-bromocamphor-10-sulphonic, cysteic, benzenesulphonic, p-chlorobenzenesulphonic, 2-mesitylbenzenesulphonic, 4-biphenylsulphonic, 1-naphthalenesulphonic, 2-naphthalenesulphonic, 5-sulphosalicylic, p-acetylbenzenesulphonic, 1,2-ethanedisulphonic, o-benzenedisulphonic and chondroitinesulphuric acids, and double salts of said acids with sulphuric acid.
2.
A stable salt according to claim 1 selected from the group consisting of the S-adenosil-L-methionine (SAM) salt of methanesulphonic acid and the double salt of said acid with sulphuric acid.
3.
A stable salt according to claim 1 selected from the group consisting of the S-adenosil-L-methionine (SAM) salt of ethanesulphonic acid and the double salt of said acid with sulphuric acid.
4.
A stable salt according to claim 1 selected from the group consisting of the S-adenosil-L-methionine (SAM) salt of 1-n-dodecanesulphonic acid and the double salt of said acid with sulphuric acid.
5.
A stable salt according to claim 1 selected from the group consisting of the S-adenosil-L-methionine (SAM) salt of 1-n-octadecanesulphonic acid and the double salt of said acid with sulphuric acid.
6.
A stable salt according to claim 1 selected from the group consisting of the S-adenosil-L-methionine (SAM) salt of 2-chloroethanesulphonic acid and the double salt of said acid with sulphuric acid.
7.
A stable salt according to claim 1 selected from the group consisting of the S-adenosil-L-methionine (SAM) salt of 2-bromoethanesulphonic acid and the double salt of said acid with sulphuric acid.
8.
A stable salt according to claim 1 selected from the group consisting of the S-adenosil-L-methionine (SAM) salt of 2-hydroxyethanesulphonic acid and the double salt of said acid with sulphuric acid
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Molecular Biology 
