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Molecular Biology

Synthetic-method

Marek's disease virus vaccine

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OF THE PRESENT INVENTION In the compounds of formula (I), where R.sup.2 represents a group of the ...

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OF THE INVENTION The process of the present invention results in esterification of erythorbic and ...

Tolan-type nematic liquid crystalline compounds

What is claimed is: 1. A compound of the general formula ##STR184## wherein R represents a linear ...

Process for extracting lignin from lignocellulosic material using an aqueous organic solvent and an acid neutralizing agent

OF THE PREFERRED EMBODIMENTS With reference to FIG. 1, the results shown therein were in relation ...

Finely divided suspension of cellulosic material

An object of this invention is to provide a suspension containing finely divided particles of a ...

Synthetic method

Details

Inventors: Denny, William Alexander; Lee, Ho Huat;
Assignee: BTG International Limited (London, GB)
Primary Examiner: Pryor; Alton
Assistant Examiner:
Attorney, Agent or Firm: Nixon & Vanderhye

A process for the preparation of the compound AQ4 of formula 3: ##STR1## or a salt or N-oxide thereof, includes the step: ##STR2##

DETAILED DESCRIPTION What is claimed is: 1.
A process for the preparation of the compound AQ4 of formula 3: ##STR16## or a salt or N-oxide thereof, including the step: ##STR17## 2.
A process as claimed in claim 1 in which the step of converting the compound of formula 21 to the compound of formula 9 is carried out using a nitrogen atmosphere.
3.
A process as claimed in claim 1 in which the step of converting the compound of formula 21 to the compound of formula 9 is carried out by heating to cause sublimation of solid, with frequent remelting of the sublimate.
4.
A process as claimed in claim 1 in which the step is conducted over a layer of powdered anhydrous KF and/or NaF.
5.
A process as claimed in claim 4 in which the step is conducted over a mixture of anhydrous KF and NaF.
6.
A process as claimed in claim 5 in which the mixture of KF and NaF contains from 10% to 60% by weight of NaF and from 90% to 40% by weight of KF.
7.
A process as claimed in claim 6 in which the mixture of KF and NaF contains around 17% by weight of NaF and around 83% by weight of KF.
8.
A process as claimed in claim 5 in which the compound of formula 21, KF, and NaF are present in the following amounts:
5 parts by weight dichlorophthalic anhydride (21);
10 to 25 parts by weight KF; and
2 to 6 parts by weight NaF.

9.
A process as claimed in claim 5 in which the compound of formula 21, KF, and NaF are present in the following amounts:
5 parts by weight dichlorophthalic anhydride (21);
around 20 parts by weight KF; and
around 4 parts by weight NaF.

10.
A process as claimed in claim 1 in which the step of converting the compound of formula 21 to the compound of formula 9 is conducted at a temperature of 260-270.
degree.
C.

Description:
The invention relates to a process for the preparation of AQ4 and derivatives thereof including AQ4N, a bis-bioreductive agent with of value in the treatment of cancer.
AQ4N is an anthraquinone, and would normally be synthesised by oxidation of AQ4 (3): ##STR3## AQ4N is in fact a prodrug and the reverse reaction occurs in vivo, reductive metabolism in hypoxic cells giving the active agent, AQ4, in its protonated form

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