 Plant watering indicator |
| I claim: 1. Apparatus for indicating when a plant requires to be watered comprising, a member ... |
|
| Affinity detection apparatus |
| In the immunoassay apparatus disclosed herein, the coated member and well have complimentary shapes ... |
|
| Sulfide containing tin stabilizers |
| What is claimed is: 1. A monoorganotin or diorganotin mercaptoalkyl ester of a carboxylic acid or ... |
|
| Method for enzyme reutilization |
| OF THE INVENTION Waste materials containing cellulose which have previously been disclosed as ... |
|
| Compounds that bind to digitalis receptor |
| What we claim is: 1. A C3-glycoside derivative of a 14.beta.-hydroxypregnane and having the formula:... |
|
| Reticulated cellulose and methods and microorganisms for the production thereof |
| The present invention includes a reticulated bacterial cellulose product having novel properties. T... |
|
| Glycopetide antibiotic PA-45052-B |
| OF THE INVENTION The present inventors found that the strain belonging to the genus Nocardia ... |
|
| Production of pure sugars and lignosulfonates from sulfite spent liquor |
| According to the present invention, sulfite spent liquor is subjected to a two-step chromatographic ... |
|
| Chromatographic separator sorbent bed preparation |
| This invention provides a sorbent bed packing procedure which minimizes sorbent bed compartment ... |
|
| Simulated moving bed chromatographic separation |
| What is claimed is: 1. In a method for the separation of an extract component from a raffinate ... |
|
|
Thrombin inhibitory new dihydroxybenzene ether derivatives
| Details |
Inventors: Boshagen, Horst; Horlein, Ulrich; Reinhardt, Gerd; Seuter, Friedel; Perzborn, Elisabeth;
Assignee: Bayer Aktiengesellschaft (Leverkusen, DE)
Primary Examiner:
Assistant Examiner:
Attorney, Agent or Firm:
An ether derivative of a dihydroxybenzene of the formula ##STR1## in which R.sup.1 is 1 to 3 identical or different substituents selected from hydrogen, halogen, trifluoromethyl, carboxyl, alkyl, alkoxy, alkylmercapto and carbalkoxy, with in each case 1 to 4 carbon atoms in the alkyl and alkoxy groups, and R.sup.2 and R.sup.3 are different and each is an alkyl or alkenyl chain in which 1 or 2 CH.sub.2 chain members are optionally replaced by O, S, CO or a phenylene group, and/or in which the chain is optionally substituted by 1 to 3 identical or different substituents selected from hydroxyl, halogen, trifluoromethyl, phenyl, carboxyl, alkyl, alkoxy, alkylmercapto, carbalkoxy, and acyl, the phenyl radical in turn optionally being substituted by halogen, trifluoromethyl, carboxyl, alkyl, alkoxy, alkylmercapto or carbaloxy, and the abovementioned alkyl, alkoxy and acyl groups in each case containing 1 to 4 carbon atoms, and in which at least one of the radicals R.sup.2 or R.sup.3 is substituted and/or in at least one of the radicals R.sup.2 or R.sup.3 1 or 2 chain members are replaced by 1 or 2 identical or different radicals selected from O, S, CO and phenylene, is effective in combating cardiac infarcations, angina pectoric, thromboembolic illnesses, in venous and arterial regions and arteriosclerosis. |
|
DETAILED DESCRIPTION We claim: 1.
An ether derivative of a dihydroxybenzene of the formula ##STR40## wherein the ether groups are either ortho- or meta- to one another; A is selected from the group consisting of --COOH, --COOC.
sub.
2 H.
sub.
5, --CH.
dbd.
CH--COOH and --CH.
dbd.
CH--COOC.
sub.
2 H.
sub.
5 ; B is an alkyl radical having from 3 to 6 carbon atoms, and n is 1 to 3, or a pharmaceutically acceptable salt thereof.
2.
A compound according to claim 1, wherein such compound is of the formula ##STR41## or a pharmacologically acceptable salt thereof.
3.
A compound according to claim 1, wherein such compound is of the formula ##STR42## or a pharmacologically acceptable salt thereof.
4.
A compound according to claim 1, wherein such compound is of the formula ##STR43## or a pharmacologically acceptable salt thereof.
5.
A compound according to claim 1, wherein such compound is of the formula ##STR44## or a pharmacologically acceptable salt thereof.
6.
A compound according to claim 1, wherein such compound is of the formula ##STR45## 7.
A thrombin-inhibitory composition comprising a thrombin-inhibiting effective amount of a compound according to claim 1 in admixture with a diluent.
8.
A unit dose of a composition according to claim 7 in the form of a tablet, pill, dragee, capsule, ampoule or suppository.
9.
A method of combating cardiac infarctions, angina pectoric, thromboembolic illnesses in the venous and arterial region and arteriosclerosis in human and non-human animals which comprises administering to the animals a thrombin-inhibitory effective amount of a compound according to claim 1.
10.
The method according to claim 9, wherein such compound is ##STR46## or a pharmacologically acceptable salt thereof.
Description:
The present invention relates to certain new dihydroxybenzene ether derivative compounds, to a process for their production and to their use as antithrombotic agents, in particular as thromboxan synthetase inhibitors and as thrombin inhibitors, and as antiatherosclerotic agents
|
| Related patents |
|
|
Deer repellent device and method
What is claimed is: 1. A deer repellent assembly comprising: a 100 foot length of one-quarter inch diameter elongate flexible rope of a cotton and polyester solid braid ...
|
|
|
Solid consumer product compositions containing small particle clyclodextrin complexes
What is claimed is: 1. Pharmaceutical composition comprising an effective amount of active/cyclodextrin inclusion complex with pharmaceutical agent selected from the ...
|
|
|
Water-dispersible protein/polyurethane reaction product
OF THE INVENTION In the process of our invention the isocyanate-capped liquid polyurethane prepolymer acts as: (a) a solvent to dissolve the protein which is to be ...
|
|
|
Polyurethane hydrogels having enhanced wetting rates
What we claim is: 1. A method of improving the wetting rate of a water swellable, lightly crosslinked hydrogel polymer which comprises contacting said polymer with a ...
|
|
|
Solid, water-dispersible plastics precursors containing isocyanate groups, a process for the production of aqueous plastics dispersions using such plastics precursors
OF THE INVENTION The plastics precursors according to the present invention are produced by the methods known in polyurethane chemistry, i.e. by reacting organic ...
|
|
|
Pharmaceutical composition containing bile acid sequestrant enclosed in a size-exclusion membrane
OF THE PREFERRED EMBODIMENT In describing the preferred embodiment, certain terminology will be utilized for the sake of clarity. It is intended that such terminology ...
|
|
|
Process for the preparation of insecticidal, nematicidal and acaricidal 2-halo-3-substituted-5-arylpyrrole compounds
OF THE INVENTION One of the preferred embodiments of the present invention involves reacting a formula II substituted acetonitrile compound as described above with at ...
|
|
|
Transparent impact polymers
OF THE INVENTION The monomers of the feed mixture of this invention are selected from three specific types and may include a fourth type. Monomer (a) is a styrenic ...
|
|
|
Oil reclaimer
I claim: 1. An apparatus for removing impurities from lubricating oil, comprising, a container having upper and lower ends, said container having an oil inlet opening ...
|
|
|
Visual-type hygrometer
What is claimed is: 1. The complexes of the alkali metals salts of 3,3',4,4' benzophenone tetracarboxylic acid in which the alkali metal salt is complexed with from 0.5 ...
|
|
|
Molecular Biology 
