 Method for purifying microbial polysaccharides |
| What is claimed is: 1. A method for removing bacterial cells from an aqueous mixture comprising a ... |
|
| Juice squeezer for citrus fruits |
| What we claim is: 1. A juice squeezer for squeezing citrus fruits, the squeezer comprising a ... |
|
| Process for measuring the plasminogen content of a sample |
| What I claim is: 1. The process of measuring the plasminogen content of a plasma sample comprising ... |
|
| Method for producing thrombolytic preparation |
| What is claimed is: 1. In a method for producing a thrombolytic preparation from a fresh urine or a ... |
|
| Anti-Sm hybridoma |
| What is claimed is: 1. A continuous cell line which produces anti-Sm antibodies of the IgG class in ... |
|
| Aqueous concentrates of salts of .alpha.-sulfonated fatty acid alkyl esters |
| What is claimed is: 1. An aqueous paste which can be readily pumped at a temperature of about 60.... |
|
| Process for the production of organic fuel |
| The exact nature of the cellulosic starting material used in the process of this invention is not ... |
|
| Process for the fermentative production of acetone, butanol and ethanol |
| We claim: 1. The improved process for the production of butanol, acetone and ethanol, by the ... |
|
| Mutant strain of C. acetobutylicum and process for making butanol |
| We claim: 1. A method of producing butanol which comprises anaerobically culturing a biologically ... |
|
| Azido-silane compositions |
| What is claimed is: 1. A solubilized azido-containing silane composition of matter produced by a ... |
|
|
Various 15-deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostaglandins
| Details |
Inventors: Floyd, Jr., Middleton B.; Weiss, Martin J.; Grudzinskas, Charles V.; Chen, Sow-mei L.;
Assignee: American Cyanamid Company (Stamford, CT)
Primary Examiner: Gerstl; Robert
Assistant Examiner:
Attorney, Agent or Firm: Johnson; Norton S.
15-Deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostanoic acids and congeners thereof, useful as bronchodilators, hypotensive agents and as agents for the control of excessive gastric secretion. |
|
DETAILED DESCRIPTION We claim: 1.
An optically active compound of the formula: ##STR24## wherein R.
sub.
1 is selected from the group consisting of hydrogen and C.
sub.
1 to C.
sub.
6 alkyl; R.
sub.
2 is selected from the group C.
sub.
3 to C.
sub.
7 alkyl; R.
sub.
3 is selected from the group consisting of hydrogen and hydroxy; X is selected from the group consisting of a divalent moiety of the formula: ##STR25## wherein R.
sub.
5 is selected from the group consisting of ethynyl, 1-propynyl and trimethylsilylethynyl; Z is selected from the group consisting of --(CH.
sub.
2).
sub.
6 --, --(CH.
sub.
2).
sub.
4 SCH.
sub.
2 -- and --(CH.
sub.
2)--O--CH.
sub.
2 --; the racemic mixture thereof; the mirror image thereof; and, when R.
sub.
1 is hydrogen, the pharmacologically acceptable salts thereof.
2.
A compound according to claim 1, wherein Z is --(CH.
sub.
2).
sub.
6 --.
3.
A compound according to claim 1, wherein Z is selected from the group consisting of --(CH.
sub.
2).
sub.
4 OCH.
sub.
2 -- and --(CH.
sub.
2).
sub.
4 --S--CH.
sub.
2.
4.
A compound according to claim 2, wherein R.
sub.
3 is hydroxyl.
5.
A compound according to claim 2, wherein R.
sub.
3 is hydrogen.
6.
A compound according to claim 3, wherein R.
sub.
3 is hydroxyl.
7.
A compound according to claim 3, wherein R.
sub.
3 is hydrogen.
8.
The compound according to claim 4, wherein R.
sub.
1 is methyl or ethyl.
9.
The compound according to claim 5, wherein R.
sub.
1 is methyl or ethyl.
10.
The compound according to claim 6, wherein R.
sub.
1 is methyl or ethyl.
11.
The compound according to claim 4, dl-11.
alpha.
,16-dihydroxy-9-oxo-16-ethynyl-20-ethyl-13-trans-prostenoic acid.
12.
The compound according to claim 4, dl-methyl-11.
alpha.
,16-dihydroxy-9-oxo-16-ethynyl-13-trans-prostenoate.
13.
The compound according to claim 6, dl-11.
alpha.
,16-dihydroxy-9-oxo-3-oxa-16-ethynyl-13-trans-prostenoic acid.
14.
The compound according to claim 4, dl-11.
alpha.
,16-dihydroxy-9-oxo-16-(1-propynyl)-13-trans-prostenoic acid.
15.
The compound according to claim 6, dl-11.
alpha.
,16-dihydroxy-9-oxo-3-oxa-16-(1-propynyl)-13-trans-prostenoic acid
|
|
Molecular Biology 
