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Home Nonmetallic Processes Method-for-improving-adsorption-of-a-drug-from-ethylene-oxide-derivative

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 Method for improving adsorption of a drug from ethylene oxide derivative

Details
Inventors: Yoshihara, Keiichi; Sako, Kazuhiro;
Assignee: Astellas Pharma Inc. (Tokyo, JP)
Primary Examiner: Hui; San-Ming
Assistant Examiner:
Attorney, Agent or Firm: Townsend and Townsend and Crew LLP

The present invention relates to a method for improving adsorption on the gastrointestinal mucous layers of one or more selected from polyethylene glycol, polyethylene oxide, and polyoxyethylene polypropylene copolymer wherein the average number of repeating oxyethylene units of one ethylene oxide chain length is 17 or greater. It is possible to enhance pharmacological effects by using the present invention with drugs that have anti-H. pylori activity.

DETAILED DESCRIPTION The invention claimed is: 1.
A method for improving adsorption of a drug on the gastrointestinal mucous layers, characterized in that one or more selected from polyethylene glycol, polyethylene oxide, and polyoxyethylene polypropylene copolymer where the average number of repeating oxyethylene units of one ethylene oxide chain length is 17 or greater is administered as the active ingredient for improving adsorption of a drug.
2.
The method for improving adsorption of a drug on the gastrointestinal mucous layers according to claim 1, wherein the drug is an antibiotic.
3.
A pharmaceutical composition for improving adsorption of a drug on the gastrointestinal mucous layers, which contains at least a drug and one or more selected from polyethylene glycol, polyethylene oxide, and polyoxyethylene polypropylene copolymer where the average number of repeating oxyethylene units of one ethylene oxide chain length is 17 or greater.
4.
The pharmaceutical composition for improving adsorption of a drug on the gastrointestinal mucous layers according to claim 3, where the drug is an antibiotic.
5.
The pharmaceutical composition according to claim 3, wherein the ratio of the components of the composition when the administration form is a liquid is 0.
00005% to 50% of drug and 0.
1% to 37.
5% of ethylene oxide derivative per total composition and/or 0.
1 mg to 1 g of drug and 2 mg to 1 g of ethylene oxide derivative.
6.
The pharmaceutical composition according to claim 3, wherein the ratio of the components of the composition when the administration form is a solid is 0.
01% to 95% of drug and 5% to 99.
99% of ethylene oxide derivative per total composition and/or 0.
1 mg to 1 g of drug and 50 mg to 1 g of ethylene oxide derivative.




Description:
FIELD OF THE INVENTION The present invention relates to a method for improving adsorption of a drug on the gastrointestinal mucous layers characterized in administration of a specific ethylene oxide derivative as the active ingredient for improving adsorption of a drug


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