 Transparent/translucent bottles |
| OF THE INVENTION Fluorescent Dyes Classes of fluorescent dyes which may be used include stilbenes; ... |
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| Crosslinked sulfonated polyimide films |
| OF THE INVENTION The present invention provides a sufonated polyimide comprising the repeating ... |
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| Resin denture base molding apparatus |
| In view of the aforementioned problems, it is an object of the present invention to provide an ... |
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| Dental material |
| OF PREFERRED EMBODIMENTS The foregoing object is achieved by impregnating communicating holes of a ... |
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| Dental mouthpiece and method of making same |
| OF PREFERRED EMBODIMENTS Referring to FIG. 1, there is seen an arch-shaped mouthpiece substrate 10.... |
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| Method for manufacturing a dental prosthesis |
| It is the object of the present invention to provide an improved method for manufacturing fiber ... |
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| Nozzle contact device of an injection machine |
| The present invention provides a nozzle contact device of an injection machine. The nozzle contact ... |
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| Process for providing a decorative transfer in a molded product |
| In a first aspect, the present invention pertains to a decorative transfer including a backing and ... |
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| Means for centrifugally casting a plastic tubular member |
| Referring now in more detail and by reference characters to the drawings which illustrate a ... |
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| Methods for emplacing and maintaining transmission lines |
| This invention provides an external housing or conduit in the form of a prelaid, continuous ... |
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Method for making uniformly sized particles from water-insoluble organic compounds
| Details |
Inventors: Violanto, Michael R.;
Assignee: University of Rochester (Rochester, NY)
Primary Examiner: Hruskoci; Peter
Assistant Examiner:
Attorney, Agent or Firm: Kenyon & Kenyon
The invention involves a method for making uniformly sized particles from water-insoluble drugs or other organic compounds. First, a suitable solid organic compound is dissolved in an organic solvent, and the solution can be diluted with a non-solvent. Then, an aqueous precipitating liquid is infused, precipitating non-aggregated particles with substantially uniform mean diameter. The particles are then separated from the organic solvent. Depending on the organic compound and the desired particle size, the parameters of temperature, ratio of non-solvent to organic solvent, infusion rate, stir rate, and volume can be varied according to the invention. |
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DETAILED DESCRIPTION The invention involves a method of making uniformly sized particles of a solid, water-insoluble organic compound by, first, preparing a solution of the solid organic compound in a water-miscible organic solvent for the compound, the compound having essentially little aqueous solubility; second, infusing an aqueous precipitating liquid into the solution at a temperature between about -10.
degree.
C.
and about 100.
degree.
C.
and at an infusion rate of from about 0.
01 ml per minute to about 1000 ml per minute per unit volume of 50 ml to produce a suspension of precipitated solid organic compound in the form of substantially non-aggregated particles with a substantially uniform mean particle diameter selected from the range of less than about 10 microns, such that the particle size is directly related to the solution temperature and inversely related to infusion rate, and then separating the particles from the organic liquids and washing in aqueous washing liquid.
Agitation of the solution being infused with precipitating liquid is preferred.
This can be accomplished by stirring, shaking, combining two streams of liquid, by the infusing itself and by other techniques known to those skilled in the art.
In preferred embodiments of the invention, additional aqueous precipitating liquid is added to the suspension before the particles are separated from the organic solvents.
Separation can be accomplished, for example, by centrifugation, membrane filtration, reverse osmosis, or other methods.
The aqueous washing liquid can be the same as the aqueous precipitating liquid, and it can be pharmaceutically acceptable for injecting into a patient.
The aqueous precipitating liquid can be water, a solution of a mineral salt, or a surfactant solution.
Suitable aqueous surfactant solutions include 5% polyvinyl pyrrolidone C-30, 0.
1% polyvinyl pyrrolidone C-15, 0.
1% human serum albumin, 0.
1% Pluronic F-68 (poloxamer 188), and 0.
33% gelatin, alone or combined with 0.
6% hetastarch, 0.
02% propylene glycol, or 2% sucrose
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Nonmetallic Processes 
